Clinical trials: Eosinophilic Esophagitis
EoE, Eosinophilic Esophagitis
Mepo for Eosinophilic Esophagitis (EoE) Study
Multi-center, randomized, double blind, parallel-arm, placebo controlled trial to determine whether mepolizumab is more effective than placebo for improving symptoms of dysphagia and decreasing esophageal eosinophil counts in…
- Trial name
- NCT03656380
- Testing
- Mepolizumab 300 mg, Mepolizumab 100 mg
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of North Carolina, Chapel Hill
Eosinophilic Esophagitis
Innate Immunity in Eosinophilic Esophagitis
The main aim of this study is to assess the expression of innate lymphoid cells in the esophageal mucosa of children with eosinophilic esophagitis (EoE) and in control subjects
- Trial name
- CLOE (NCT03640975)
- Testing
- Endoscopy
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eosinophilic Esophagitis (EoE)
Bethanechol for Eosinophilic Esophagitis
The primary goals of this study are to ease the symptoms of patients with Eosinophilic Esophagitis (EoE) and to test the effectiveness of the drug bethanechol in relieving those symptoms.
- Trial name
- NCT02058537
- Testing
- Bethanechol
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Iowa
Allergy, Asthma
Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory Disorders
This study will evaluate and follow patients with various allergic, hypersensitivity and inflammatory disorders. The protocol is not designed to test new treatments; patients will be managed with standard of care therapies.
- Conditions
- Allergy, Asthma, Allergic Rhinitis, Mastocytosis
- Trial name
- NCT00557895
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Food Allergy, Loeys-Dietz Syndrome
Natural History and Genetics of Food Allergy and Related Conditions
Background: About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.
- Conditions
- Food Allergy, Loeys-Dietz Syndrome, Atopic Dermatitis, Eosinophilic Esophagitis
- Trial name
- NCT02504853
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophilic Esophagitis (EoE)
Surface EMG Testing on Swallowing in EoE Patients
Evaluating swallowing food with surface electromyography (EMG) machine in patients with Eosinophilic Esophagitis
- Trial name
- sEMG (NCT07156357)
- Testing
- Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Autism Spectrum Disorder, Eosinophilic Gastrointestinal Disorders
Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study
This single-case exploratory clinical study aims to evaluate the therapeutic potential of umbilical cord blood (UCB) infusion in a pediatric patient diagnosed with both eosinophilic duodenitis (ED) and autism spectrum disorder…
- Trial name
- NCT06995274
- Testing
- Umbilical Cord Blood Infusion (Autologous and Allogeneic)
- Volunteers
- 1 people
- Sponsor
- Bundang CHA Hospital
Esophagitis, Eosinophilic
Outcome of Children With Eosinophilic Esophagitis
The investigator would like to create a prospective cohort of patients in order to describe eosinophilic esophagitis with the specificities corresponding to our geographical territory, and to study their evolution at 3 months, 6…
- Trial name
- Obs-OE (NCT06190080)
- Testing
- Digestive endoscopy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Fondation Lenval
Eosinophilic Esophagitis
The Role of HRM and Specific Biomarkers of Inflammation in the Diagnosis of Patients With Dysphagia and Suspected EoE
The aim of the project is to assess the correlation between the results of high-resolution oesophageal manometry and specific biomarkers of inflammation (eotaxin 3, major basic protein, IL-5, IL-13, TGF-beta1) with symptoms of…
- Trial name
- NCT04803162
- Testing
- High-resolution manometry, Serum biomarkers, Gastrointestinal Quality of Life index
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Wroclaw Medical University
Eosinophilic Esophagitis
Endoscopic Characterisation of Inflammation in EoE
In this study, we plan to investigate the accuracy of the EG-760Z endoscope (135x zoom) compared with standard imaging with histology as gold standard in detecting and grading inflammatory activity in patients with eosinophilic…
- Trial name
- ECI-EoE (NCT04769232)
- Testing
- EG-760Z endoscope by Fujifilm
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Eosinophilic Gastritis, Eosinophilic Gastroenteritis
Efficacy and Safety of Benralizumab in Patients With Eosinophilic Gastritis and/or Gastroenteritis (The HUDSON GI Study)
This is a 3-part study. Part A is randomized, double-blinded, placebo-controlled and includes patients with eosinophilic gastritis and/or duodenal-only disease.
- Trial name
- HUDSON GI (NCT05251909)
- Testing
- Benralizumab
- Where
- 20 sites in United States, Brazil and 7 more
- Volunteers
- 12 people
- Sponsor
- AstraZeneca
Eosinophilic Gastritis, Eosinophilic Duodenitis
A Study to Assess Subcutaneous AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, tolerability, and pharmacodynamic effect of subcutaneous lirentelimab (AK002), given monthly for 6 doses, in…
- Trial name
- ENIGMA-SC (NCT05152563)
- Testing
- AK002
- Where
- 76 sites in United States
- Sponsor
- Allakos Inc.
Oesophagitis, Eosinophilic
An Evaluation Of Mepolizumab In Therapy Of Eosinophilic Oesophagitis In Adult Patients
Eosinophils play a key role in the pathogenesis of eosinophilic oesophagitis. Therapies that suppress eosinophil recruitment and activation may give a benefit.
- Trial name
- NCT00274703
- Testing
- mepolizumab
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- GlaxoSmithKline
Food Hypersensitivity, Anaphylaxis
A Registry for the Food Allergy Community
The FARE Patient Registry will serve as a prospective, observational food allergy reporting system that stores detailed health and other basic information about patients' real-world experiences with food allergies, to encourage…
- Conditions
- Food Hypersensitivity, Anaphylaxis, Eosinophilic Esophagitis, Food Sensitivity
- Trial name
- FPR (NCT04653324)
- Where
- United States
- Volunteers
- 23,000 people
- Sponsor
- Food Allergy Research & Education
Eosinophilic Esophagitis Caused by Food (Disorder)
EoE Food Test Pilot Study
The objective of this study is to determine the performance characteristics of a series of novel, non-invasive allergen-activated T cell assays designed to identify Eosinophilic esophagitis (EoE) causal foods, when used in…
- Trial name
- NCT07023380
- Testing
- Assay directed diet change
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Eosinophilic Esophagitis
CEGIR 7807: Validation of Online Cohort of EGID Patients Enrolled in RDCRN CEGIR Contact Registry
The purpose of this study is to validate the online cohort of EGID patients enrolled in the RDCRN CEGIR CR. In order to achieve this objective, the investigators will determine the agreement between self-reported EGID information…
- Trial name
- NCT03382678
- Where
- 2 sites in United States
- Volunteers
- 187 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Eosinophilic Esophagitis
An Intervention Study to Improve Therapeutic Compliance in Adult Patients With Eosinophilic Esophagitis.
In many chronic conditions adherence to long-term treatment is a challenge, also for patients with eosinophilic esophagitis. Interventions, such as behavioral, educational and reminder interventions might improve treatment…
- Trial name
- NCT05730933
- Testing
- Intervention
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Eosinophilic Esophagitis
Budesonide for Eosinophilic Esophagitis
Eosinophilic Esophagitis (EE) is a chronic, T-helper 2 cell (TH2) - type inflammatory disorder of the esophagus with a rapidly increasing prevalence.
- Trial name
- BEE (NCT00271349)
- Testing
- Budesonide
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- Swiss EE Study Group
Eosinophilic Esophagitis
Somatization, Anxiety, and Disordered Sleep in Pediatric Eosinophilic Esophagitis
Eosinophilic esophagitis
- Trial name
- NCT04309786
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Diego
Gastroesophageal Reflux Disease, Eosinophilic Esophagitis
The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors
Background: Up to 40% of patients who are treated with PPIs for symptoms that are thought to be due to GERD experience only incomplete relief of their symptoms.
- Trial name
- NCT01404832
- Testing
- Treat with lansoprazole 30 mg BID for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Dallas VA Medical Center