Clinical trials: Epidural Analgesia, Obstetric
Labor Pain
A Novel Approach to Optimize Programmed Intermittent Epidural Bolus (PIEB) Delivery for Labour Analgesia
Programmed intermittent epidural bolus (PIEB) for labour analgesia allows an epidural pump to be programmed to deliver small amounts of the local anesthetic and opioid solution at regularly timed intervals.
- Trial name
- NCT03871530
- Testing
- Coordinate A, Coordinate B, Coordinate C
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- IWK Health Centre
Hypotension, Labor Complication
Leg Elevation to Prevent Hypotension During Labor
When hypotension is related to epidural placement, this can occur within 15-60 minutes after placement. The purpose of this study is to build upon this preliminary work and to use a randomized controlled trial to examine the…
- Trial name
- NCT05674838
- Testing
- Leg Elevation
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Laboring Women Requesting Neuraxial Labor Analgesia
Comparison of Epidural Labor Pain Relief Techniques on Maternal and Fetal Outcomes
The primary objective of this study is to compare the onset and duration of the initial dose of medications given through three different epidural (conventional epidural, combined spinal epidural and dural puncture epidural)…
- Trial name
- NCT02008591
- Testing
- Epidural Technique versus Dural Puncture Epidural Technique versus Combined Spinal Epidural Technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brigham and Women's Hospital
Labour Pain
Spoken Animation for Labour Epidural
The purpose of this study is to evaluate a new animated information film as a tool for introducing the concept of epidural as a method of labour pain relief to expectant women.
- Trial name
- SALE (NCT07202221)
- Testing
- Participant views Epidural animation before reading gold standard written information, Participant receives current gold standard written information alone
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Obstetric Pain, Other Complications of Obstetric Anesthesia - Delivered
Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome
To assess the efficacy of epidural dexamethasone administration, compared to placebo, in reducing local anesthetics consumption during labor epidural analgesia in parturient women
- Trial name
- DEXAPER (NCT02857465)
- Testing
- Dexamethasone, Ropivacaine, Sufentanil
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Depression, Postpartum, Pregnancy
Labor Pain and Postpartum Behavioral Health Outcomes Study
In this pilot prospective longitudinal observational study, women who are pregnant and who will be experiencing childbirth for the first time will be recruited at the third trimester and observed longitudinally for psychiatric…
- Conditions
- Depression, Postpartum, Pregnancy, Child Development, Pain
- Trial name
- LPPD (NCT02692404)
- Where
- 2 sites in United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Epidural Analgesia for Labour and Delivery
Cross-legged Versus Traditional Sitting Position for the Success of Epidural Analgesia During Labor
The success of an epidural analgesia catheter placement depends on the parturient position. A poor posture can increase the number of punctures, patient discomfort, and risk of complications.
- Trial name
- IP3 (NCT04754282)
- Testing
- Position of labouring women for epidural analgesia catheter placement : Traditional Sitting Position (TSP), Position of labouring women for epidural analgesia catheter placement : Cross-legged Sitting Position (CSP)
- Where
- France
- Volunteers
- 457 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Pain, Obstetric Pain
Association Between Bolus Rate and the Adequacy of Labor Analgesia Using Timed-intermittent Boluses
Administration of anesthetic solution into the epidural space is usually accomplished by a combination of continuous infusion, provider-administered boluses and patient-administered boluses (patient controlled epidural analgesia…
- Trial name
- NCT02340806
- Testing
- CADD-Solis pump (Smiths Medical)
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Labor Pain and to Reduce Pain
Does the Volume of Medication Affect the Success of Labor Epidural Analgesia
The purpose of this study is to evaluate whether changing the volume and concentration of a medication affects the quality of pain relief and the side effects associated with labor epidural analgesia.
- Trial name
- EpiVol (NCT07684365)
- Testing
- administration of bupivacaine 7.5 mg and fentanyl 24 mcg every 40 minutes
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pregnancy
Use of Ultrasound in Obstetric Neuraxial Analgesia and Anesthesia Data Base
This is a data base building project on the use of pre-procedure ultrasound for the performance of labor epidural pain relief and spinal anesthesia for cesarean deliveries.
- Trial name
- NCT01192074
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Epidural Analgesia, Obstetric, Maternal Satisfaction
Impact of Patient Choice for Epidural Potency on Maternal Satisfaction
This clinical trial will compare two different approaches to epidural analgesia during labor to see which approach leads to higher patient satisfaction after delivery.
- Trial name
- NCT07414407
- Testing
- Patient-selected epidural management, Standard epidural management
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Delivery, Obstetric, Labor, Obstetric
Effects of a Lateral Position With Hip Flexion and Femoral Internal Rotation During the Second Stage of Labor in Nulliparous Women Receiving Epidural Analgesia
This randomized clinical study evaluated the effects of a lateral position with hip flexion and femoral internal rotation during the second stage of labor in nulliparous women receiving epidural labor analgesia.
- Trial name
- NCT07745192
- Testing
- Lateral Position With Hip Flexion and Femoral Internal Rotation, Conventional Lateral Position
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pregnancy, Epidural Analgesia, Obstetric
Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: a Sibling Matched Clinical Ambidirectional Cohort Study
In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries).
- Trial name
- NCT07014956
- Testing
- Labour epidural analgesia
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epidural Analgesia for Labour and Delivery
M-mode Ultrasonography for Epidural Catheter Identification and Confirmation of Correct Catheter Position
In France, 80% of women choose epidural analgesia for delivery and birth. The localization of the epidural space is classically achieved by loss of resistance to saline.
- Trial name
- ETEMERC (NCT05897814)
- Testing
- Location of the epidural analgesia catheter
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Patch, Post-Dural Puncture Headache
Factors Associated With the Onset of Chronic Headaches in Patients Who Received a Blood Patch in Post Partum
The purpose of this study is to identify possible links between conditions for carrying out a blood patch (BP) to treat accidental post dural puncture acute headache (PDPH) in the early post partum period and occurrence of…
- Trial name
- CHROBLOOD (NCT05888324)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy, Labor and Delivery
Ropivacaine and Fentanyl for Labor Epidural Initiation
This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor.
- Conditions
- Pregnancy, Labor and Delivery, Labor Analgesia
- Trial name
- EV90_DPE (NCT07076368)
- Testing
- Ropivacaine + Fentanyl
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Labor Pain
The Effect of a Culturally Sensitive Educational Intervention on Acceptance of Neuraxial Anesthesia
The purpose of this study is to see if an educational intervention provided to pregnant women in early labor has an effect on their decision to use epidural anesthesia for relief of labor pain.
- Trial name
- NCT02672397
- Testing
- Additional Epidural Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obstetric Pain, Analgesia
Study Comparing Dural Puncture Epidural With Epidural and Combined Spinal Epidural Anesthesia for Obstetric Analgesia.
This will be a prospective, randomized, double blind, controlled clinical trial. Epidural analgesia (EP) is currently the method of choice to ensure the comfort of the parturient during childbirth.
- Trial name
- NCT05196256
- Testing
- Dural puncture, Combined spinal epidural analgesia, Epidural analgesia
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Brugmann University Hospital
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center