Clinical trials: Epidural Block
Pain
Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of the most commonly used drugs for that purpose. The efficacy of a certain medication injected epidurally depends on the dose that is given.
- Trial name
- NCT01972269
- Testing
- Bupivacaine-fentanyl, Lidocaine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pancreatic Cancer
Effects of Erector Spina Plan Block and Epidural Analgesia in Whipple Surgery
Pancreatic surgery is generally a high-risk and difficult to manage perioperatively. surgery. In pancreatic surgery, in addition to general anaesthesia, central blocks for analgesia and peripheral blocks are also preferred.
- Trial name
- NCT06254430
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Labor Pain, Labor; Prolonged, Second Stage
Remifentanil vs. Combined Spinal-epidural Analgesia for Labor Analgesia and Progress of Labor in Multiparous
Remifentanil may be an ideal drug for labor analgesia due to its pharmacodynamic and pharmacokinetic profile. As compared to epidural analgesia, it demonstrated satisfactory for pain relief at the beginning of labour with a…
- Conditions
- Labor Pain, Labor; Prolonged, Second Stage, Labor; Prolonged, First Stage
- Trial name
- NCT02963337
- Testing
- remifentanil, combined spinal-epidural analgesia
- Where
- Slovenia
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
To Determine the Onset of Analgesia (Numerical Rating Scale for Pain = 1) in Minutes
Comparison of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques
Epidural, Combined Spinal-Epidural, and more recently dural puncture epidural are forms of neuraxial anesthesia used to provide pain relief in laboring women .
- Trial name
- NCT03258879
- Testing
- Modified CSE, Dural puncture epidural
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Acute Postoperative Pain
Ultrasound Guided Bilateral Erector Spinae Block Versus Caudal in Lumbar Spine Surgeries
Major lumbar spine surgeries are associated with severe postoperative pain that usually lasts for at least 3 days.Caudal epidural analgesia has a crucial role in providing effective pain relief post lumbar spine surgeries by…
- Trial name
- NCT05351203
- Testing
- caudal block, Erector spinae block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery
Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries
Clinical efficacy and safety of dexmedetomidine as an adjuvant in quadratus lumborum versus epidural block in postoperative patients
- Trial name
- NCT06130670
- Testing
- nerve block
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Labor Pain
A Comparison of Epidural Analgesia: Continuous Infusion Versus Programmed Intermittent Boluses
The analgesic approach in labor can be done in different ways, among which the neuraxial approach has shown the best analgesic results and fetal outcomes.
- Trial name
- NCT02510287
- Testing
- Bupivacaine and Fentanyl Initial Dose, Bupivacaine and Fentanyl: Continuous Epidural Infusion, Bupivacaine and Fentanyl: Programmed Intermittent Epidural Bolus
- Where
- Colombia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Epidural Space Depth
Ultrasound Guidance for Epidural Analgesia and Anesthesia
Most women delivering by cesarean at BC Women's receive regional anesthesia; which includes spinal, epidural, or combined spinal-epidural anesthesia.
- Trial name
- NCT02436109
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post Operative Pain
Pre-emptive Caudal Epidural Analgesia With Ropivacaine With or Without Dexamethasone in Lumbosacral Spine Surgery
Lumbosacral spine surgeries are commonly performed under GA. Perioperative pain following spine surgeries not only contributes to significant morbidities but also hampers early mobilization.
- Trial name
- NCT05904275
- Testing
- caudal epidural injection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Trauma Center
Pain, Epidural Analgesia
"Loss of Resistance" Versus CompuFlo® for Epidural Placement
The purpose of this study is to compare how well the CompuFlo® computerized syringe pump works as compared to the traditional method of inserting an epidural (a needle placed in one's back to give pain medicine).
- Trial name
- NCT00178750
- Testing
- 18G Tuohy epidural needle, CompuFlo® computerized syringe pump
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Surgical Anesthesia, Cesarean Section
Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Regional anesthesia is commonly used for elective and emergency cesarean delivery. It provides numerous safety advantages when compared to general anesthesia for both the mother and fetus1.
- Trial name
- NCT03414359
- Testing
- 2% Lidocaine, 3% Chloroprocaine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Arthroplasty, Replacement, Knee, Nerve Block
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
The purpose of this study is to further investigate the efficacy of adductor canal nerve blocks for pain management after total knee replacement.
- Trial name
- NCT02121392
- Testing
- Adductor Canal Nerve Block Catheter, Bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Labor Pain, Analgesia, Epidural
A Study on the Effect of Position on Walking Labour Epidural Efficacy
This study is being done to better understand how patient positioning can affect pain relief after an epidural. In addition to pain, the investigators will assess how position affects epidural spread, and its effects on maternal…
- Trial name
- NCT04469101
- Testing
- Lumbar Epidural
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Epidural, Analgesia
Epidural Analgesia and Delivery of Second Twin
Over an 8-year period, 124 twin pregnancies at gestational age ≥32 weeks with both twins presenting as a vertex and eligible for vaginal delivery were reviewed.
- Conditions
- Epidural, Analgesia, Labor Pain
- Trial name
- Epidural (NCT04608006)
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Abdelrady S Ibrahim, MD
Pregnant Women Who Requested Epidural Analgesia in the Early Stage of Labor
Onset of Labour Epidural Analgesia With Different Concentration Bupivacaine and Different Doses of Sufentanyl
This study aimed to compare the effects of three commonly used combination doses on the onset time and adverse reactions.
- Trial name
- NCT03395600
- Testing
- B1S5, B125S5, B1S10
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pain Relief
Nociception Monitoring During Epidural Analgesia
Introduction and aim: Nociception monitors have been used to assess pain management in anesthetized patients. The investigators set out to evaluate whether Nociception Level (NOL) monitor (PMD-200 monitor with NOL technology …
- Trial name
- NCT06456177
- Testing
- Assessment of nociception in obstetric patients during epidural analgesia
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Labor Pain
Changes in Velocimetric Indices of Uterine and Umbilical Arteries Before and After Combined Spinal-epidural Analgesia in Laboring Women (PART II)
Combined spinal-epidural (CSE) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief.
- Trial name
- NCT06655675
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Labor Pain
Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using…
- Trial name
- NCT05781854
- Testing
- Epidural analgesia with bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Epidural Analgesia, Epidural Analgesia for Labour and Delivery
EpiFaith Resident Learning Curve Trial
This study aims to evaluate the impact of the EpiFaith® syringe on the learning curve of anesthesia residents for the labor epidural technique.
- Conditions
- Epidural Analgesia, Epidural Analgesia for Labour and Delivery, Learning Curve
- Trial name
- NCT07395622
- Testing
- EpiFaith epidural syringe, Control (glass) syringe
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain
Comparison of Quadratus Lumborum Block and Epidural Analgesia Following Kidney Transplant Surgery
Quadratus lumborum block as an alternative for postoperative analgesia compared with epidural block
- Trial name
- NCT03771339
- Testing
- Continuous Epidural analgesia, Bilateral Quadratus Lumborum block
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia