Clinical trials: Epigenetic Therapy
Prostate Cancer (Adenocarcinoma)
Development of a Novel Signature Integrating Clinical, Imaging And Epigenetic Information to Tailor Pelvic Nodal Treatment in Prostate Cancer
Radical prostatectomy (RP) represents one treatment option for clinically localized prostate cancer (PCa). The most updated guidelines of the European Association of Urology indicate the need to perform ePLND in patients with a…
- Trial name
- RF-2018-123683 (NCT06807398)
- Testing
- Data will be used to develop a novel predictive model assessing the risk of LNI.
- Where
- Italy
- Volunteers
- 367 people
- Sponsor
- Francesco Montorsi
Male Infertility
Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
Single center, prospective, open clinical study to determine the genomic imprint (epigenetic modification) in a series of male infertility patients with alterations in their spermiogram (oligozoospermia) compared to a group of…
- Trial name
- NCT02605070
- Testing
- Bravelle
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Oestrogen Receptor Positive Advanced Breast Cancer
An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis
Determine the overall response rate (ORR) at 48 weeks to everolimus (RAD001, 10mg daily p.o.) and exemestane (25mg daily p.o.) treatment in postmenopausal women with oestrogen receptor positive breast cancer who have previous…
- Trial name
- 4EVERUK (NCT01743560)
- Testing
- RAD001, Exemestane
- Where
- 11 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, HER2-positive Breast Cancer
Entinostat Plus Pyrotinib and Endocrine Therapy in Advanced Triple-Positive Breast Cancer After Trastuzumab Failure
This is an open-label, single-center, exploratory, Phase Ib/II clinical trial evaluating the safety and efficacy of entinostat combined with pyrotinib and endocrine therapy in patients with advanced hormone receptor-positive…
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Hormone Receptor-Positive Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT07708194
- Testing
- entinostat, Pyrotinib, endocrine therapy
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Lung Neoplasms, Neoadjuvant Therapy
To Conduct Multi-omics Integrated Studies in Peripheral Blood, Such as Fragment Omics, Metabolomics and Epigenetics, and Establish Non-invasive Dynamic Follow-up Monitoring Programs During Perioperative and Postoperative Periods (Observational Study)
This project aims to innovatively integrate multi-omics data, including plasma metabolomics, radiomics, and cfDNA multi-level information, combined with survival data (e.g., RFS), to establish a novel multidimensional approach…
- Conditions
- Lung Neoplasms, Neoadjuvant Therapy, Immunotherapy, Minimal Residual Disease
- Trial name
- NCT07291921
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
GBM
Methylation Patterns of the NUPR1, MGMT, NDRG2, and GLI1 Genes and Their Impact on Therapeutic Outcome of GBM Patients
The study aimed to investigate the role of promoter methylation of MGMT, NUPR1, NDRG2, and GLI1 genes in glioblastoma multiforme (GBM) patients.
- Trial name
- NCT06538428
- Testing
- DNA methylation profiling
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Neuroendocrine Tumors
Lutathera and ASTX727 in Neuroendocrine Tumours
Patients entered into the study will receive ASTX727 orally for 5 days, prior to receiving Lutathera treatment on Day 8, to determine whether pre-treatment with ASTX727 results in re-expression of somatostatin receptor-2 in…
- Trial name
- LANTana (NCT05178693)
- Testing
- ASTX727, Lutathera
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Imperial College London
Male Infertility, Cancer
Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment
The prognosis in cancer patients has improved over the years. Survivor rates have increased significantly, and paternity has become an important concern in more than 50% of young male survivors.
- Conditions
- Male Infertility, Cancer, Epigenetic Disorder
- Trial name
- NCT04200118
- Testing
- Observational
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- IVI Barcelona
Immune Checkpoint Inhibitor, Chemotherapy Effect
Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell Lymphoma
This prospective pilot study to evaluate the efficacy and safety of the anti-PD-1 antibody combine with Peg-asparaginase and Chidamide regimen for stage IE and IIE ENKTL.
- Conditions
- Immune Checkpoint Inhibitor, Chemotherapy Effect, Epigenetic Disorder, NK/T-cell Lymphoma of Nasal Cavity
- Trial name
- NCT04414969
- Testing
- Anti-PD-1 antibody+Peg-Asparaginase+Chidamide
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Hunan Cancer Hospital
Major Depressive Disorder, Suicidal Ideation
Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation
The study aims to use a combined clinical and translational approach to identify an efficient pharmacotherapy for the acute management of suicidality and the epigenetic regulation associated with the treatment.The primary…
- Trial name
- AFSP (NCT01134731)
- Testing
- paliperidone, lithium
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Stroke
Rehabilomics Study in Stroke Patients After Robotic Rehabilitation
Stroke is associated with disability and impaired quality of life. Persistent motor impairment is common with incomplete recovery of motor function after rehabilitation, mainly in the upper limbs (UL).
- Trial name
- NCT04223180
- Testing
- Robotic assisted intervention
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
HCC
CXD101 in Immunotherapy-related Liver Cancer
For hepatocellular carcinoma (HCC), durable responses and improved survivals have been reported in clinical trials on immune checkpoint inhibitor (ICI)-based treatment.
- Trial name
- NCT05873244
- Testing
- Zabadinostat (CXD101) and Geptanolimab, Lenvatinib and Sorafenib
- Where
- 2 sites in Hong Kong
- Volunteers
- 26 people
- Sponsor
- Stephen Chan Lam
Head and Neck Cancer
Evaluation of an Oral Care Programme for Head and Neck Cancer Patients
This study will evaluate the effect of an intensified oral care programme on prevalence, severity and duration of mucositis in patients undergoing treatment for cancer in the head and neck region.
- Trial name
- NCT03481647
- Testing
- Oral care programme
- Where
- 2 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Göteborg University
Refractory Solid Tumors
A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors
Chemotherapy resistance, either innate or acquired requires for its development, expression changes on a large number of genes therefore, it has been hypothesized that epigenetic-mediated changes could be the responsible driving…
- Trial name
- NCT00404508
- Testing
- Hydralazine and magnesium valproate
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- National Institute of Cancerología
Locally Advanced Breast Cancer
Hydralazine and Valproate Added to Chemotherapy for Breast Cancer
Aberrant DNA methylation and histone deacetylation participate in cancer development and progression, as epigenetic alterations are common to breast cancer, in this phase II study, the demethylating hydralazine plus the HDAC…
- Trial name
- NCT00395655
- Testing
- Hydralazine and magnesium valproate administration, Core-needle biopsy of the breast
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- National Institute of Cancerología
Cervical Cancer
Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer
The current standard for locally advanced cervical cancer is concurrent cisplatin-based chemotherapy, however, the treatment results need to be improved.
- Trial name
- NCT00404326
- Testing
- Hydralazine and magnesium valproate, Punch biopsy of the primary tumor
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- National Institute of Cancerología
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDS
The goal of this project is to see if two new potential treatments (defactinib and the combination tablet of decitabine/cedazuridine) can safely be combined to improve outcomes in people with high-risk myelodysplastic syndrome…
- Conditions
- Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia
- Trial name
- CELESTIAL-MDS (NCT05636514)
- Testing
- Decitabine/Cedazuridine 35 Mg-100 Mg ORAL TABLET, Defactinib
- Where
- 5 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Clinical Hub for Interventional Research (CHOIR)
Well-Being, Psychological, Loneliness
Physiological, Hormonal, and DNA-based Mechanisms of Psychosocial Stress and Therapeutic Effect
The goal of this trial is to learn if the Groups 4 Health (G4H) intervention is effective in supporting student well-being at the University of Helsinki.
- Trial name
- NCT07152652
- Testing
- Groups 4 health
- Where
- Finland
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Major Depressive Disorder
Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment
The investigators aim to characterize fecal microbial biomarkers as well as blood cytokine levels in MDD patients vs. healthy controls.
- Trial name
- NCT03703414
- Testing
- Fecal microbiota composition analysis and blood cytokine level analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Helicobacter Pylori Infection, Dysbiosis
The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication
Helicobacter pylori (H. pylori) infection is the major cause of gastritis, peptic ulcer disease, and gastric cancer in adults. Bismuth-based quadruple therapy is recommended by a recent review to be the first-line treatment for…
- Conditions
- Helicobacter Pylori Infection, Dysbiosis, Probiotics
- Trial name
- Bsm10 (NCT04527055)
- Testing
- Bismuth Subcitrate 120 MG Oral Tablet, Lactobacillus acidophilus and Bifidobacterium lactis Bb12, Esomeprazole 40mg
- Where
- Taiwan
- Volunteers
- 312 people
- Sponsor
- National Cheng-Kung University Hospital