Clinical trials: Epigenetics
Healthy
Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA
The goal of this clinical trial is to learn whether a dietary supplement can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07127445
- Testing
- OEA supplement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nicole Stevens, PhD
Seminomas
Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours
Recent data suggest that sperm cells carry an epigenetic message during spermatogenesis and that this message is crucial for the future development of the embryo.
- Trial name
- GAMETH (NCT03262207)
- Testing
- Extraction genomic DNA, Analysis of methylation profiles of numerous GSI and TE, Analysis of methylation for the whole genome (sub-population of 15 samples from group 1)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Cancer
"Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients"
The role of epigenetic regulators and their dysregulation in cancer have gained much attention recently, as they influence the gene expression of many oncogenes and tumor suppressor genes.
- Trial name
- NCT06759714
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Trained Immunity, BCG Vaccine
BCG-induced Epigenetic Modifications in the NEXT Generation
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune…
- Conditions
- Trained Immunity, BCG Vaccine, Epigenetics
- Trial name
- NEXT (NCT05766345)
- Testing
- BCG-Vaccine SSI [Statens Serum Institut]) Danish strain 1331
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy
Genetic and Epigenetic Mechanisms Underlying Cocoa Health Benefits
Evaluate if gene expression changes in SOD2 explain the health benefits of high polyphenols cocoa
- Trial name
- NCT02292576
- Testing
- Cocoa Pure
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Hydatidiform Moles
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
The researchers' laboratory is studying a rare class of highly recurrent hydatidiform moles. These are usually complete hydatidiform moles (CHM), but sometimes they are partial hydatidiform moles PHM).
- Trial name
- NCT01008501
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Peri-Implantitis, Peri-implant Mucositis
Histological, Genetic and Epigenetic Analysis of Procedures Related with Dental Implants
In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression of peri-implant diseases and…
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Implant Complication, Implant Tissue Failure
- Trial name
- NCT04421066
- Testing
- Gingival and bone sample collection, Healthy individuals
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Simón Pardiñas López
IBS - Irritable Bowel Syndrome
The Effect of Dietary Intervention on Symptoms, Epigenetics, and Gut Microbiota in IBS
The aim of the present study is to research whether subjects with irritable bowel syndrome (IBS) display epigenetic/genetic changes or altered microbiota compared to a non-IBS control group.
- Trial name
- NCT03306381
- Testing
- Dietary intervention
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Region Skane
Fatigue Syndrome, Chronic
Epigenetics of Post-exertional Malaise in Patients With ME/CFS
Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology.
- Trial name
- EPIME (NCT04378634)
- Testing
- Exercise, Mental Stress Test
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Male Infertility
Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
Single center, prospective, open clinical study to determine the genomic imprint (epigenetic modification) in a series of male infertility patients with alterations in their spermiogram (oligozoospermia) compared to a group of…
- Trial name
- NCT02605070
- Testing
- Bravelle
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Opioid Use Disorder, Addiction
Epigenetic Biomarker for Opioid Use Disorder
Study rationale Opioid use disorder (OUD) is a chronic and severe condition, defined by problematic opioid use, which results from interactions among sociological factors, psychiatric symptoms and life experiences, altogether…
- Trial name
- EBIOMOUD (NCT05419986)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Malaria, Bacterial Co-infection
Host Immunity, Plasmodium and Pathogens Co-Infections
Few studies have focused on malaria co-infections, mainly caused by Plasmodium falciparum, occurring mainly in children under 5 years of age in sub-Saharan Africa.
- Trial name
- HIPPI (NCT06769815)
- Testing
- Blood sample, Urine sample, oropharyngeal sample
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Aging
Epigenetics in the Aging Process
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process.
- Trial name
- NCT00242255
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity, Diabetes
Epigenetic Mechanisms and Severe Obesity (Biological Tissue Collection)
The purpose of this study was to evaluate the role of vitamin status and epigenetic mechanisms on severe obesity related-complications.
- Conditions
- Obesity, Diabetes, Metabolic Diseases, Non-alcoholic Fatty Liver Disease
- Trial name
- OBESEPI (NCT02663388)
- Testing
- gastric bypass, sleeve, gastric banding
- Where
- France
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Lorraine
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Mitochondrial Diseases
Mitochondrial Stress, Brain Imaging, and Epigenetics
The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A>G mitochondrial DNA (mtDNA)…
- Trial name
- MiSBIE (NCT04831424)
- Testing
- Trier social stress test
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Columbia University
Childhood Obesity, Epigenetics
Early Childhood Obesity Programming by Intrauterine Growth Restriction
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from…
- Trial name
- NCT03402139
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Emergence Delirium, Postoperative Complications
Epigenetics in PostOperative Pediatric Emergence Delirium
Emergence delirium (ED) infers the occurrence of behavior and cognition changes during the early postoperative period. Main signs and symptoms of ED are the disturbances of consciousness and awareness of the environment, with…
- Conditions
- Emergence Delirium, Postoperative Complications, DNA Methylation
- Trial name
- EPOPED (NCT03787849)
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Aging
The Impact of a Fast Diet and Calorie Mimetic Supplements on Epigenetic Aging
This is a prospective randomized clinical study of 50 patients to evaluate the fasting mimicking diet program by Prolon with a calorie mimetic supplement from Peak Human Labs.
- Trial name
- NCT04962464
- Testing
- Peak Human Labs calorie mimetic supplement, Fasting Mimicking Diet
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic