Clinical trials: Epilepsy Sleep
CSWS, Developmental and/or Epileptic Encephalopathies
Melatonin for the Treatment of DEE-SWAS
The goal of this study is to learn if melatonin, a naturally produced substance, can help to treat some of the symptoms of DEE-SWAS, a type of epilepsy that causes children to lose skills and development.
- Conditions
- CSWS, Developmental and/or Epileptic Encephalopathies, Electrical Status Epilepticus in Sleep
- Trial name
- NCT07221968
- Testing
- Melatonin
- Volunteers
- 3 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Epilepsy
Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy
This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy…
- Trial name
- NCT04788628
- Testing
- Baseline, Motor procedural memory task, Motor procedural memory task plus auditory stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Chronic Insomnia, Epilepsy
PREDiction of Different Variants of Sleep Stages for the Diagnosis Support of Chronic Insomnia and Epilepsy
The objective of this study is to develop and validate deep learning algorithms for automated sleep stage and sub-stage classification using overnight polysomnography data.
- Conditions
- Chronic Insomnia, Epilepsy, Sleep Disorders
- Trial name
- PREDSomADICE (NCT07547501)
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Refractory Epilepsy, Sleep
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG.
- Trial name
- NCT06524479
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Insomnia
Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities
The purpose of the study is to evaluate the safety and efficacy of oral melatonin in improving sleep continuity in children with epilepsy and neurodevelopmental delay who have chronic insomnia by comparing Fast Release Melatonin…
- Conditions
- Epilepsy, Insomnia, Developmental Disability
- Trial name
- NCT01161108
- Testing
- Fast Release Melatonin (FR MLT), Timed Release Melatonin (TR MLT)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Epileptic Encephalopathy, Continuous Spike and Wave During Sleep
Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep
This is a phase 2, double-blind study to assess the efficacy, safety, tolerability, and pharmacokinetics of NBI-827104 when administered once daily for 13 weeks in pediatric subjects with Epileptic Encephalopathy with Continuous…
- Trial name
- NCT04625101
- Testing
- NBI-827104
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 24 people
- Sponsor
- Neurocrine Biosciences
Epilepsy
Melatonin vs Sleep Deprivation for Nap EEG
In the pediatric population, electroencephalographic (EEG) recordings are frequently performed in sleep, as it reduces the amount of artifacts and might activate epileptiform discharges.
- Trial name
- NCT05654415
- Testing
- Melatonin, Deprivation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Sleep Deprivation, Epilepsies, Partial
A Study of Lyrica as Treatment for Sleep Problems in Patients With Sleep Problems and Seizures
The purpose of this study is to determine the effects of pregabalin on sleep problems in patients with seizures.
- Trial name
- NCT00643136
- Testing
- Pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 17 people
- Sponsor
- Pfizer
Epilepsy，Cognition
Clinical Study on the Effect of Improving Sleep Quality on Cognitive Function in Patients With Epilepsy
Epilepsy is one of the common chronic diseases of the central nervous system. 30% to 40% of patients with epilepsy have varying degrees of cognitive impairment, which affects their quality of life.
- Trial name
- NCT05256173
- Testing
- Melatonin Tablets, Lactasin Tablets, transcutaneous vagus nerve stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Dementia, Alzheimer Disease
Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders
The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through…
- Conditions
- Dementia, Alzheimer Disease, Epilepsy, Sleep Disorder
- Trial name
- MES-CoBraD (NCT05171725)
- Testing
- EEG,PSG, biosample collection (blood and CSF), neuropsychological testing
- Where
- 4 sites in Greece, Israel and 2 more
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Neurological Institute of Athens
Epilepsy
The Effect of Progressive Relaxation Exercises Applied to Patients With Epilepsy
Epilepsy; It is a disease characterized by sudden, repetitive, epileptic seizures that are not triggered by an identifiable event and occur as a result of abnormal and excessive electrical discharge in cortical neurons from…
- Trial name
- NCT05127499
- Testing
- progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Rolandic Epilepsy
Changing Agendas on Sleep, Treatment and Learning in Epilepsy
Rolandic epilepsy (RE) is the most common type of epilepsy. Children with RE have seizures and can often find that their learning, sleep, behaviour, self-esteem and mood are affected.
- Trial name
- CASTLE (NCT04610879)
- Testing
- Carbamazepine, Levetiracetam, Parent based sleep (PBS) intervention
- Where
- 3 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- King's College London
Brain Tumors, Epilepsy
Quality Improvement and Practice Based Research in Neurology Using the EMR
The investigators will conduct at NorthShore University HealthSystem pragmatic trials using the EMR for 10 common neurological disorders.
- Conditions
- Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment
- Trial name
- NCT02670161
- Testing
- Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Endeavor Health
Healthy, Exercise
Heart Rate Changes During Normal Activity, Exercise, and Sleep in Normal Healthy Subjects With and Without Epilepsy
The purpose of this study is to gather ECG data during normal activity, exercise, and sleep from normal subjects with or without well-controlled epilepsy.
- Trial name
- NCT01202682
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cyberonics, Inc.
Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy
The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study
In clinical practice language impairment is frequently reported in association with nocturnal epileptiform activity. There is a spectrum of epileptic conditions that are characterized by nocturnal epileptiform activity.
- Conditions
- Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy, Landau-Kleffner Syndrome, Electrical Status Epilepticus During Slow Wave Sleep
- Trial name
- REL (NCT01335425)
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Seizures, Sleep
Pediatric Seizure Movement Bed Alarm
Nocturnal seizure and Sudden unexplained death in epilepsy patients (SUDEP) are major concerns for parents and creates anxiety and poor sleep conditions for many families dealing with epilepsy.
- Conditions
- Seizures, Sleep, Epilepsy
- Trial name
- PedsBedAlarm (NCT01855178)
- Testing
- Emfit Movement Monitor
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Le Bonheur Children's Hospital
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
KCNT1-Related Epilepsy
A Natural History Study of Participants With Potassium Sodium-Activated Channel Subfamily T Member 1 (KCNT1)-Related Epilepsy
The primary objective of the study is to characterize seizures in participants with KCNT1-related epilepsy. The secondary objectives are to characterize head growth, symptom severity, neurocognitive and social functions, adaptive…
- Trial name
- K1Te (NCT04924153)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Biogen
Epilepsy, Partial
Determine Effects of Adjunctive Levetiracetam on Sleep Architecture in Adults With Partial Onset Epilepsy.
Effect of adjunctive levetiracetam on polysomnography in adults with partial-onset epilepsy receiving a classical antiepileptic drug
- Trial name
- NCT00245713
- Testing
- levetiracetam
- Volunteers
- 40 people
- Sponsor
- UCB Pharma
Alzheimer Disease, Alzheimer Dementia
Prevalence of Epilepsy and Sleep Wake Disorders in Alzheimer Disease
Alzheimer disease is the most common of the neurodegenerative diseases. Epilepsy and sleep wake disorders are co-morbid conditions of Alzheimer disease.
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Epilepsy, Sleep Wake Disorders
- Trial name
- PESAD (NCT03617497)
- Testing
- scalp EEG and polysomnography, scalp EEG with foramen ovale electrodes with polysomnography
- Where
- Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven