Clinical trials: Epileptic Seizures
Epilepsy, Seizures, Infantile
Clinical-genetic Investigations in Children With Early Infantile Epilepsies
The project strives to discover novel genetic defects that cause monogenic epilepsy or that genetically modify a preexisting epileptic phenotype.
- Trial name
- NCT01357707
- Testing
- DNA preparation
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Markus Schuelke, M.D.
Infantile Spasms
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
This is a randomized, controlled study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.
- Trial name
- NCT00968136
- Sponsor
- Yonsei University
Epilepsies, Partial
Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures
This study will determine the safety and efficacy of pregabalin (Lyrica) when administered by itself (without any other anti-epileptic medication) to epilepsy subjects for the treatment of partial seizures.
- Trial name
- NCT00524030
- Testing
- pregabalin 600 mg/day, pregabalin 150 mg/day
- Where
- 73 sites in United States, Czechia and 2 more
- Volunteers
- 161 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Epilepsy
Atkins Plus KetoCal for Childhood Epilepsy
The modified Atkins diet (MAD) is a relatively new, alternative dietary therapy for intractable childhood and adult epilepsy. Recent evidence suggests that a strict, highly ketotic, first month may be advantageous to both…
- Trial name
- NCT00681239
- Testing
- Modified Atkins diet and KetoCal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Epilepsy
The Impact of Mindfulness Meditation in Veterans With Epilepsy
Epilepsy is one of the fourth most common neurological disorder and affects people of all ages and about 25 % of those patients have medically intractable epilepsy.
- Trial name
- NCT03589755
- Testing
- Mindfulness meditation
- Where
- United States
- Sponsor
- Miami VA Healthcare System
Epilepsy, Cognitive Dysfunction, Cognitive Disorder
HOBSCOTCH-YOUTH and Young Adults
The goal of this clinical trial is to learn more about the home-based epilepsy self-management program, HOBSCOTCH, for improving cognitive function (thinking and memory) and quality of life specifically in young adults, ages 18 …
- Conditions
- Epilepsy, Cognitive Dysfunction, Cognitive Disorder, Memory and Thinking Problems
- Trial name
- NCT07735715
- Testing
- HOBSCOTCH/HOBSCOTCH-YOUTH
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Epilepsy, Dravet Syndrome
A Dose-ranging Pharmacokinetics and Safety Study of GWP42003-P in Children With Dravet Syndrome (GWPCARE1)
To evaluate the safety and pharmacokinetics (PK) of multiple doses of GWP42003-P compared with placebo in children with Dravet syndrome.
- Trial name
- NCT02091206
- Testing
- GWP42003-P 5 mg/kg/day Dose, GWP42003-P 10 mg/kg/day Dose, GWP42003-P 20 mg/kg/day Dose
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 34 people
- Sponsor
- Jazz Pharmaceuticals
Neonatal Seizures
EAGLET: EEG vs aEEG to Improve the Diagnosis of neonataL Seizures and Epilepsy
The current project undertakes a prospective multicentre randomised controlled trial to evaluate whether full or continuous electroencephalography (cEEG) is superior to amplitude-integrated electroencephalography (aEEG) in the…
- Trial name
- EAGLET (NCT05079971)
- Testing
- Group B: aEEG with concurrent multichannel (full) continuous cEEG review by clinical neurophysiology
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Seizures
Pathogenesis of Adverse Drug Reactions
The purpose of the study is to examine the individual metabolic profiles of pediatric patients receiving carbamazepine or valproate therapy, in an attempt to determine identities of the reactive metabolites or, alternatively, the…
- Trial name
- NCT00224952
- Testing
- No intervention; Urine Collection
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Children's Mercy Hospital Kansas City
Epilepsy, Complex Partial
Dose Response Study of Zonegran in Patients With Newly Diagnosed Epilepsy
The purpose of this study is to determine whether zonisamide alone is effective as a treatment for epilepsy in newly diagnosed cases.
- Trial name
- NCT00056576
- Testing
- Zonisamide
- Where
- 35 sites in United States, Estonia and 3 more
- Volunteers
- 165 people
- Sponsor
- Eisai Inc.
Seizures, Brain Diseases
A Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection
The ANSeR Clinical Investigation is a multi-centre, randomised, controlled, clinical investigation of a standalone decision support Algorithm for Neonatal Seizure Recognition, the ANSER Software system.
- Conditions
- Seizures, Brain Diseases, Central Nervous System Diseases, Epilepsy
- Trial name
- ANSeR (NCT02431780)
- Testing
- ANSeR Software System
- Where
- 8 sites in Ireland, Netherlands and 2 more
- Volunteers
- 264 people
- Sponsor
- University College Cork
Epilepsy, Status Epilepticus
Training Program to Improve EEG Competence
The goal of this clinical trial is to investigate the extent to which a practice-oriented training program for intensive care nursing staff and non-physician treatment teams can contribute to the earlier detection of epileptic…
- Conditions
- Epilepsy, Status Epilepticus, Status Epilepticus, Electrographic, Status Epilepticus, Non-Convulsive
- Trial name
- EPI-Train (NCT07689084)
- Testing
- Training Program
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Marburg
Epilepsy
Evaluation of Memory and Forgetting in Patients With Epilepsy
Drug-resistant focal epilepsy (DRFE) is frequently associated with complications of varying severity that impair patient's quality of life.
- Trial name
- EPIMNESIE (NCT04924933)
- Testing
- Computerised associative memory task using abstract words and landscape photographs
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Value of Smartphone in Epilepsy
Diagnostic Value of Smartphone Video in Epileptic Seizures
1. Accuracy of seizure diagnosis based on smartphone seizure semiology anaysis 2. Assess the factors that affect the diagnostic reliability of smartphone videos
- Trial name
- NCT05574725
- Testing
- Smartphone
- Volunteers
- 84 people
- Sponsor
- Assiut University
Epilepsy, Focal Seizures
A Study of GWP42006 in People With Focal Seizures - Part B
To investigate the potential antiepileptic effects of GWP42006 as add-on therapy in subjects with inadequately controlled focal seizures.
- Trial name
- NCT02365610
- Testing
- GWP42006
- Where
- 26 sites in Czechia, Hungary and 4 more
- Volunteers
- 162 people
- Sponsor
- Jazz Pharmaceuticals
Self Management, Epilepsy; Seizure
The Individual and Family Self Management Theory Based Epilepsy Education Program's Effectiveness
The aim of the study; to determine the effect of education program given to adolescents diagnosed with epilepsy and their parents based on Ryan and Sawin's individual and family self-management theory, on adolescents 'attitudes…
- Conditions
- Self Management, Epilepsy; Seizure, Quality of Life
- Trial name
- NCT04822662
- Testing
- Epilepsy Education Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- KTO Karatay University
Major Depression, Temporal Lobe Epilepsy
Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy
This is a research study evaluating the use of escitalopram (Lexapro®) for the treatment of major depression in subjects with temporal lobe epilepsy.
- Trial name
- NCT00595699
- Testing
- escitalopram
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Conrad, Erich J., M.D.
Lennox Gastaut Syndrome (LGS)
EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment
This study plans to learn if certain markers found during electroencephalogram (EEG) analysis could predict fenfluramine responsiveness to give clinicians greater insight into the effectiveness of fenfluramine in people with…
- Trial name
- NCT07555171
- Testing
- fenfluramine HCl
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Epilepsy
Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or…
- Trial name
- NCT07085598
- Testing
- Vitamin D
- Where
- Bangladesh
- Volunteers
- 15 people
- Sponsor
- Bangladesh Medical University
Epilepsy, Partial
Follow-up Study of L059 (Levetiracetam) in Epileptic Patients With Partial Onset Seizures by Open Label Method
The safety and efficacy of L059 was evaluated in patients who completed "N165 Clinical Trial of L059". They received L059 at a daily dose from 1,000 mg to 3,000 mg in addition to their standard concomitant AEDs
- Trial name
- NCT00160615
- Testing
- Levetiracetam
- Volunteers
- 154 people
- Sponsor
- UCB Japan Co. Ltd.
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