Clinical trials: Episodic Memory
Emotion Regulation, Mood Induction
Effectiveness of Personal Relevance of Visual Autobiographical Stimuli in Positive Emotions Induction
Background: The ability to retrieve specific memories is a cognitive and emotional protective factor. Among the most effective techniques to generate autobiographical memories is the use of audio-visual stimuli, particularly…
- Conditions
- Emotion Regulation, Mood Induction, Autobiographical Memory, Ageing
- Trial name
- NCT04251104
- Testing
- Images' personal relevance effectiveness in objective and subjective mood recovery
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Follicular Lymphoma
Memory-enriched CAR-T Cells Immunotherapy for B Cell Lymphoma
The goal of this clinical trial is to study how approaches for manufacturing chimeric antigen receptor (CAR)-modified T (CAR-T) cells affect their in vivo persistence and therapeutic efficacy against B lymphoma.
- Conditions
- Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma
- Trial name
- MeCAR (NCT02652910)
- Testing
- CD19.CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xinqiao Hospital of Chongqing
Episodic Memory
Posterior Cingulate Cortex and Executive Control of Episodic Memory
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex (PCC) to episodic memory behavior.
- Trial name
- NCT06540976
- Testing
- Cognitive testing
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pennsylvania
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Test Anxiety
Influence of Chocolate With Plant Additives on Episodic Memory in Healthy Subjects Experiencing Test Anxiety
Randomized, blind parallel group design. Single intake of 55 g high Epicatechin /Melissa dark chocolate containing 160 mg Epicatechin per 55 g serving or single intake of 55 g low Epicatechin/ oat bran white chocolate containing…
- Trial name
- MaRS-Basel (NCT03382067)
- Testing
- High Epicatechin/ Melissa, Low Epicatechin/ Oat bran
- Where
- Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Healthy Volunteers
Contextual Associations During Episodic Recall of Everyday or Virtual Reality
The project is dedicated to development of new paradigms to investigate memory and attention in the rich and realistic environments.
- Trial name
- BREAL (NCT03286387)
- Testing
- Functional brain imaging without any contrast agent
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Malignant Brain Neoplasm, Recurrent Malignant Brain Neoplasm
CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children
This phase I trial investigates the side effects of chemotherapy and cellular immunotherapy in treating children with IL13Ralpha2 positive brain tumors that have come back after a period of improvement (recurrent) or do not…
- Conditions
- Malignant Brain Neoplasm, Recurrent Malignant Brain Neoplasm, Refractory Malignant Brain Neoplasm
- Trial name
- NCT04510051
- Testing
- Cyclophosphamide, Fludarabine, IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- City of Hope Medical Center
Mild Cognitive Impairment
Improvement of Memory in Mild Cognitive Impairment
The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory…
- Trial name
- NCT05708001
- Testing
- transcranial alternating current stimulation (tACS), high-density electroencephalography (hdEEG), Montreal Cognitive Assessment (MoCA)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Behavior
Neural Mechanisms for Reducing Interference During Episodic Memory Formation
Healthy individuals from the University of Oregon and surrounding community will be recruited for participation in behavioral, fMRI and eye tracking experiments that investigate human memory.
- Trial name
- NCT05092100
- Testing
- Visual stimulus similarity, fMRI, Eye tracking
- Where
- United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma
This phase I trial studies the side effects and best dose of CS1-chimeric antigen receptor (CAR) T therapy after chemotherapy in treating patients who have CS1 positive multiple myeloma that has come back (relapsed) or does not…
- Trial name
- NCT03710421
- Testing
- CS1-CAR T Therapy, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Autobiographical Memory, Function of the Human Hippocampus
fMRI Studies of Memory and Perception
Episodic memory allows us to project ourselves back in time to mentally re-experience the past in vivid detail. This remarkable feat helps to define our personal identities and enables context-appropriate predictions that guide…
- Trial name
- NCT07860281
- Testing
- Participants use a smartphone to replay self-generated autobiographical memory cues.
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Florida State University
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Psilocybin, Music Intervention
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
The goal of this clinical trial is to understand how personally meaningful, autobiographically salient music compares to standardized playlists when combined with psilocybin in healthy adults ages 21 to 75.
- Trial name
- PRoMiSS (NCT07180108)
- Testing
- Psilocybin (high dose), Playlist 1, Playlist 2
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Infant Nutrition Disorders, Health Behavior
Sharing Histories: Test of a Teaching Method for Community Health Workers
The purpose of this study is to determine the effectiveness of an innovative methodology for training Community Health Workers that will improve their effectiveness in educating mothers to adopt best practice health behaviors in…
- Trial name
- NCT02903602
- Testing
- Sharing Histories training method for CHW, Standard training method for CHW
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Future Generations Graduate School
Mild Cognitive Impairment
Memory Training in Patients With Amnestic Mild Cognitive Impairment
Preview research reports evidence of cognitive plasticity among individuals with amnestic Mild cognitive Impairment, and small-size studies have suggest that this population can benefit from memory training.
- Trial name
- NCT01978353
- Testing
- Memory Training, Psychoeducation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Dementia
Creating Physical Objects With 3D Printers to Stimulate Reminiscing for Memory Loss [2 R44 AG049548-02A1]
In 2013 an estimated 5 million people age 65 and older had Alzheimer's disease. Longer life spans and aging baby boomers will cause this number to grow rapidly.
- Trial name
- NCT03625973
- Testing
- 3D-RT, RT-Verbal
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Moai Technologies LLC
Episodic Memory
Episodic Memory Integration and Interference
The purpose of this study is to assess how emotional memories integrate and interfere with one another over time. We will be using a multi-session experimental paradigm consisting of two encoding sessions and one retrieval…
- Trial name
- NCT05974371
- Testing
- emotional context similarity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Boston College
Memory, Alzheimer Disease
Autobiographical Specificity
Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific…
- Conditions
- Memory, Alzheimer Disease, Frontotemporal Dementia
- Trial name
- ESAD (NCT05642351)
- Testing
- Autobiographical reminder
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Nantes University Hospital
Aging Well, Memory Loss
Age Stereotype Priming and Social Participation
Memory performance is shown to be affected by age stereotypes among older adults. The purpose of the study is to examine the effects of age stereotype primes on episodic memory using priming intervention.
- Trial name
- ASPSP (NCT04202120)
- Testing
- Age-related stereotyping priming, Non age-related stereotype priming
- Where
- Hong Kong
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies
This phase 1 trial studies the side effects and the best dose of donor CD8+ memory T-cells in treating patients with hematolymphoid malignancies.
- Conditions
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- Trial name
- NCT01523223
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Robert Lowsky