Clinical trials: Episodic Memory, active
Healthy Aging, Cognition
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
This pilot study aims to investigate the effects of a single oral dose of cannabidiol (CBD) on memory and attention in healthy adults aged 60 to 70 years.
- Trial name
- CBD-MAP (NCT07910292)
- Testing
- Cannabidiol (CBD)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Epilepsy Intractable
Memory Retrieval and Encoding Investigated by Neural Stimulation
The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain…
- Trial name
- MEMREINS (NCT04286776)
- Testing
- Direct electrical stimulation
- Where
- 11 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Pennsylvania
Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma
Genetically Engineered Lymphocyte Therapy After Peripheral Blood Stem Cell Transplant in Treating Patients With High-Risk, Intermediate-Grade, B-cell Non-Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of genetically engineered lymphocyte therapy and to see how well it works after peripheral blood stem cell transplant (PBSCT) in treating patients with high-risk…
- Conditions
- Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma
- Trial name
- NCT01318317
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Filgrastim, Genetically Engineered Lymphocyte Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- City of Hope Medical Center
Memory Replay, HippoCamera
A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome
Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory.
- Trial name
- NCT07008989
- Testing
- Memory replay
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston College
Huntington Disease, Autobiographical Memory
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressively worsening motor, cognitive, psychiatric, and behavioral deficits.
- Trial name
- MAMOC-MH (NCT07409597)
- Testing
- neuropsychological tests, Eye tracker use
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
B Acute Lymphoblastic Leukemia, Recurrent Acute Lymphoblastic Leukemia
Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia
This phase I trial studies the side effects and best dose of cellular immunotherapy in treating patients with high-risk acute lymphoblastic leukemia.
- Conditions
- B Acute Lymphoblastic Leukemia, Recurrent Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia
- Trial name
- NCT02146924
- Testing
- CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- City of Hope Medical Center
Autobiographical Episodic Memory
Real-World Episodic Memory
Episodic memory allows us to project ourselves back in time to mentally re-experience the past in vivid detail. This remarkable feat helps to define our personal identities and enables context-appropriate predictions that guide…
- Trial name
- NCT07862140
- Testing
- Participants use a smartphone to replay self-generated autobiographical memory cues.
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Florida State University
Epilepsy, Autobiographical Memory
Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings
The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted…
- Trial name
- CAPTURE (NCT06883981)
- Testing
- Free and Cued Recall Memory. Temporal Sequence and Spatial Memory
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid Use Disorder
Autobiographical Memory in Opioid Use Disorder
The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD.
- Trial name
- NAMO (NCT06643988)
- Testing
- MemFlex
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Juvenile Myelomonocytic Leukemia, Recurrent Acute Biphenotypic Leukemia
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant
This phase I trial studies the side effects and best dose of CD4+ and CD8+ HA-1 T cell receptor (TCR) (HA-1 T TCR) T cells in treating patients with acute leukemia that persists, has come back (recurrent) or does not respond to…
- Conditions
- Juvenile Myelomonocytic Leukemia, Recurrent Acute Biphenotypic Leukemia, Recurrent Acute Undifferentiated Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
- Trial name
- NCT03326921
- Testing
- CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR, Bone Marrow Aspiration, Biospecimen Collection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fred Hutchinson Cancer Center
Aging
Older Age and Generalization
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults.
- Trial name
- NCT07440017
- Testing
- Memory decision type
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Caitlin Bowman
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Platinum-resistant Ovarian Cancer, Recurrent Ovary Cancer
Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer
The goal of this research study is to evaluate the safety and effectiveness of the use of cytokine-induced memory-like (CIML) natural killer (NK) cell therapy in recurrent, high grade ovarian cancer (HGOC).
- Conditions
- Platinum-resistant Ovarian Cancer, Recurrent Ovary Cancer, Ovarian Cancer, Ovarian Carcinoma
- Trial name
- NCT06321484
- Testing
- Cytokine-Induced Memory-like Natural Killer Cells, Interleukin 2
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Dana-Farber Cancer Institute
Multiple Sclerosis, Memory
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple…
- Conditions
- Multiple Sclerosis, Memory, Learning
- Trial name
- E-SEP (NCT04694534)
- Testing
- Serious game, Usual HAS care
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Lille Catholic University
Acute Myeloid Leukemia, Acute Myeloid Leukemia Recurrent
CIML NK Cells With Venetoclax for AML
The purpose of this research study is to test the safety and to explore the effectiveness of infusing cytokine- induced memory-like (CIML) natural killer (NK) cells in combination with Interleukin-2 (IL-2) and standard-of-care…
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia Recurrent, Leukemia, Leukemia, Myeloid
- Trial name
- NCT06152809
- Testing
- Cytokine-Induced Memory-like Natural Killer Cells, Interleukin-2, Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Mantle Cell Lymphoma
Memory Enriched T Cells Following Stem Cell Transplant in Treating Patients With Recurrent B-Cell Non-Hodgkin Lymphoma
This phase I trial studies the highest possible dose of memory enriched T cells that can be given following standard stem cell transplant before unmanageable side effects are seen in patients with B-cell non-Hodgkin lymphoma that…
- Conditions
- Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Mantle Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Refractory Mantle Cell Lymphoma
- Trial name
- NCT02051257
- Testing
- Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells, Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- City of Hope Medical Center
Cognitive Dysfunction, Memory Disorders in Old Age
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is…
- Trial name
- NCT04558164
- Testing
- Active Theta Burst Stimulation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, Los Angeles
Memory Disorders
Development, Standardisation and Standardisation Project for a New Memory Assessment
Episodic memory (EM) is a neuropsychological marker of Alzheimer's disease (AD) (Thomas-Anterion, 2006). Current tests for its assessment do not take into account the identity and emotional aspects of memory (Van der Linden et…
- Trial name
- NEM (NCT06564779)
- Testing
- New memory assessment
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung…
- Conditions
- Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT04804644
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Memantine Hydrochloride
- Where
- 231 sites in United States, Canada
- Volunteers
- 152 people
- Sponsor
- NRG Oncology