Clinical trials: Esophageal Fistula
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia
Primary Posterior Tracheopexy Prevents Tracheal Collapse
Introduction: Children born with a blind-ending gullet (oesophagus), or Oesophageal Atresia (OA), need to undergo surgical correction in the first week of life.
- Conditions
- Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia, Oesophageal Atresia
- Trial name
- PORTRAIT (NCT06335862)
- Testing
- Randomisation between the PPT- and no-PPT-group, Primary Posterior Tracheopexy, Preoperative tracheobronchoscopy
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Surgical Infants on NG/NJ/J/G-tube Feeds, Tracheoesophageal Fistula
A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months
This is the 5th in a series of physiological studies to determine the amino acid requirements of infants. There have been 4 studies to determine tyrosine, methionine, threonine and lysine requirements in infants when they are fed…
- Conditions
- Surgical Infants on NG/NJ/J/G-tube Feeds, Tracheoesophageal Fistula, Pierre-Robin Syndrome, Diaphragmatic Hernia
- Trial name
- INFORALTHR (NCT02364843)
- Testing
- Amino Acid: Threonine
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- The Hospital for Sick Children
Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Center Study
Esophageal atresia (EA) is one of the most common gastrointestinal congenital anomalies that affects 1 in 2500 to 1 in 4000 live births.
- Conditions
- Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia, Esophageal Strictures
- Trial name
- BITES (NCT07100379)
- Testing
- Endoscopic Balloon Dilation
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Esophageal Strictures, Esophageal Leak
Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment
Esophageal stents are commonly used for benign esophageal pathology, especially strictures or esophageal mucosal defects such as leaks, fistulae, or perforations.
- Conditions
- Esophageal Strictures, Esophageal Leak, Esophageal Perforation, Esophageal Fistula
- Trial name
- NCT02751333
- Testing
- FCSEMS with Endostitch (ES), FCSEMS with No Suturing (NS), Fully Covered Self-Expanding Metal Stents (FCSEMS)
- Where
- United States
- Sponsor
- Johns Hopkins University
Tracheo Esophageal Fistula
Outcome Predictors of Trachea-esophageal Fistula
In the present study, the investigator aim to evaluate the prevalence, factors affecting outcome and the outcome of neonates with tracheoesophageal fistula.
- Trial name
- NCT05847101
- Testing
- Tracheoesophageal fistula repair
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tracheoesophageal Fistula, Esophageal Atresia With Tracheo-esophageal Fistula
Camera-based Endoscopy Allows Spontaneous Breathing Diagnostic Management in Neonates With Tracheoesophageal Fistula
The investigators aim to compare rigid tracheoscopy versus flexible tracheo-video-endoscopy in neonates requiring diagnostic assessment before undergoing a congenital tracheoesophageal fistula repair.
- Trial name
- CBESB (NCT07687628)
- Testing
- tracheoscopy performed with rigid optical tracheoscopy, flexible video endoscopy of trachea
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Papa Giovanni XXIII Hospital
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates.
- Trial name
- CO2 (NCT01467245)
- Testing
- Hypercapnia during thoracoscopy, Open surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Dysphagia, Quality of Life
Caregivers of Children With Repaired Esophageal Atresia-tracheoesophageal Fistula
Children with esophageal atresia and tracheoesophageal fistula (EA-TEF) may experience feeding and swallowing difficulties, which result in stressful interactions between children and caregivers, and potentially impact the…
- Trial name
- NCT03889041
- Testing
- Quality of life assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula
Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery
The study is primarily a descriptive study examining the physiological, ventilatory, surgical, and recovery effects of patients ≤ 6 months of age who undergo thoracoscopic surgery and to determine the accuracy of transcutaneous…
- Conditions
- Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula, Esophageal Atresia
- Trial name
- NCT02033772
- Testing
- Thoracoscopic surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Arlyne Thung
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Gastroschisis, Congenital Diaphragmatic Hernia
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal…
- Conditions
- Gastroschisis, Congenital Diaphragmatic Hernia, Duodenal Atresia, Oesophageal Atresia With Tracheo-Oesophageal Fistula
- Trial name
- SuNDiAL (NCT06731855)
- Testing
- Abdominal Surgery for congenital gut malformation in the first 5 days of life.
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool Women's NHS Foundation Trust
Achalasia, Gastric Outlet Obstruction
Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study
Currently, there is limited multi-center data on endoscopic surgery outcomes in western populations. Evaluation of these measurement would help the investigators compare them to conventional treatment modalities within current…
- Conditions
- Achalasia, Gastric Outlet Obstruction, Gastroparesis, GERD
- Trial name
- NCT05041608
- Testing
- Endoscopic Surgery
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula
Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae
Determine safety and feasibility of using institutionally prepared autologous, uncultured SVF on patients with aerodigestive and enterocutaneous fistulae secondary to malignancy, trauma or surgery.
- Conditions
- Tracheoesopharyngeal Fistula, Bronchoesophageal Fistula, Tracheoesophageal Fistula
- Trial name
- NCT03792360
- Testing
- SVF (Stromal Vascular Fraction)
- Sponsor
- Mayo Clinic
Tracheoesophageal Fistula, Esophageal Atresia
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
The investigators propose a preliminary study performing exome sequencing on samples from patients and their biologically related family members with tracheal and esophageal birth defects (TED).
- Conditions
- Tracheoesophageal Fistula, Esophageal Atresia, Laryngeal Cleft, Tracheal Stenosis
- Trial name
- TED (NCT03455881)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Esophageal Diseases
Post Market Clinical Study - Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
The aim of this post-market clinical follow-up study is to evaluate the continued safety and performance of the marketed Evolution® Esophageal Stent System (Partially- and Fully Covered).
- Trial name
- NCT05182255
- Testing
- Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 127 people
- Sponsor
- Cook Research Incorporated
Chewing Problem
Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal Fistula
The investigators aim to evaluate chewing function in children with repaired esophageal atresia-tracheoesophageal fistula (EA-TEF). Patients with repaired EA-TEF will be evaluated for age, sex, type of atresia.
- Trial name
- NCT03026491
- Testing
- Chewing evaluation
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Atrial Fibrillation, Catheter Ablation
Esophageal Damage Protection During Pulmonary Vein Ablation. Pilot Study.
Catheter ablation of atrial fibrillation with electrical isolation of the pulmonary veins in the left atrium carries risk of esophagus thermal lesion. EnsoETM is a device .
- Conditions
- Atrial Fibrillation, Catheter Ablation, Esophageal Fistula, Esophageal Diseases
- Trial name
- NCT03832959
- Testing
- EnsoETM
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Esophageal Atresia With Tracheoesophageal Fistula
Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF)
How does oesophageal atresia/trache-oesophageal fistula affect feeding and swallowing in the first year of life? Approximately 150 babies a year are born with oesophageal atresia and/or trache-oesophageal atresia.
- Trial name
- SaFE (NCT04183621)
- Testing
- high resolution impedance manometry
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust