Clinical trials: Esophageal Reflux
Barrett's Esophagus
Detection of Barrett s Esophagus in Patients Without GERD Symptoms
The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.
- Trial name
- NCT04880044
- Testing
- EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Case Comprehensive Cancer Center
Gastro Esophageal Reflux
Effect of a Combination of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate on Subjects With GastroEsophageal Reflux Disease
The aim of this study is to investigate whether a 3-week treatment with an oral melt in mouth medical device, made up with hyaluronic acid, chondroitin sulphate and magnesium trisilicate, can lead to a reduction of…
- Trial name
- NCT03883074
- Testing
- hyaluronic acid with chondroitin + sulphate + magnesium trisilicate
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- SOFAR S.p.A.
Non-erosive Gastroesphageal Reflux Disease
Safety to Evaluate the Efficacy and Safety of HIP1601 in Patients With Non Erosive Reflux Disease
The purpose of this study is to investigate the safety and clinical efficacy of HIP1601 in patients with Non-erosive gastroesphageal reflux disease.
- Trial name
- NCT04325620
- Testing
- HIP1601, HGP1805
- Where
- South Korea
- Volunteers
- 208 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Gastroesophageal Reflux Disease, Endoscopy
Anti-Reflux Mucosal Ablation(ARMA) and Anti-Reflux Mucosectomy(ARMS) in Gastroesophageal Reflux Disease
According to the current published data and treatment mechanism, ARMS may led to more stenosis while ARMA may be less effective in long term follow-up.
- Trial name
- NCT05422404
- Testing
- Anti-Reflux Mucosectomy, Anti-reflux mucosal ablation
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastroesophageal Reflux Disease
Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux Disease
The purpose of this study is to assess the efficacy and safety of Dexlansoprazole modified release (MR) (30 mg once daily [QD] or 60 mg QD) compared to placebo in relief of daytime and nighttime heartburn over 4 weeks in subjects…
- Trial name
- NCT00321984
- Testing
- Dexlansoprazole MR
- Where
- 153 sites in United States
- Volunteers
- 947 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients
Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic doses may decrease heartburn perception and…
- Trial name
- NORGERD (NCT01065649)
- Testing
- Nortriptyline
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade de Passo Fundo
Gastroesophageal Reflux Disease, Reflux Esophagitis
The Efficacy of i-Scan for Detecting Reflux Esophagitis
Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed.
- Trial name
- NCT01381991
- Testing
- i-scan
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Non-erosive Gastroesophageal Reflux Disease
Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)
The purpose of this study was to evaluate the efficacy and safety of oral TAK-438 10 mg once-daily in the treatment of non-erosive gastroesophageal reflux disease (NERD).
- Trial name
- NCT02954848
- Testing
- TAK-438 10 mg
- Where
- 30 sites in Japan
- Volunteers
- 484 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease, Globus Pharyngeus
Manual Therapy Effects on Upper and Lower Esophageal Sphincter Pressures
The aim of this study is to test the influence of manual cervical traction and chest stabilization maneuvers on pressures in upper and lower esophageal sphincters.
- Trial name
- NCT03871426
- Testing
- manual therapy
- Where
- Czechia
- Volunteers
- 54 people
- Sponsor
- University Hospital, Motol
Gastroesophageal Reflux Disease
Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease
This study is a double blinded randomized clinical trial with two arms which aims to study the effects of diaphragmatic myofascial release in patients with gastroesophageal reflux disease (GERD).
- Trial name
- GERD (NCT03299985)
- Testing
- Diaphragmatic myofascial release
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Cardenal Herrera University
Inferior Nasal Turbinate Hypertrophy, Extraesophageal Reflux
Effect of Extraesophageal Reflux on Inferior Nasal Turbinates Hypertrophy
The study examines the severity of extraesophageal reflux using oropharyngeal pH monitoring in patients with varying degrees of lower turbinates hypertrophy.
- Trial name
- NCT04581174
- Testing
- 24-hour monitoring of oropharyngeal pH by Restech, RYAN scores upright and supine, and pH values <5.5 will be evaluated
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Varicose Veins
RCT - Does Treating Incompetent Perforators Reduce Recurrence?
The aim of this randomised case-controlled trial is to investigate whether ablation of incompetent perforating vein in addition to ablation of truncal vein reduces the rate of recurrent varicose veins post-treatment compared with…
- Trial name
- NCT01949207
- Testing
- EVLA, phlebectomies, TRansluminal Occlusion of Perforators (TRLOP)
- Where
- United Kingdom
- Volunteers
- 190 people
- Sponsor
- The Whiteley Clinic
Repeatedly Recurring Esophagitis, Relapsing Reflux Esophagitis
Nexium Capsules RE Maintenance Specific Clinical Experience Investigation
The purpose of this study is to collect following data in patients given Nexium capsule (Nexium) in usual post-marketing use as the maintenance therapy for repeatedly recurring/relapsing reflux oesophagitis.
- Trial name
- NCT01562639
- Where
- 46 sites in Japan
- Volunteers
- 647 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease, Morbid Obesity
Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass
The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.
- Trial name
- NCT00951093
- Testing
- Gastric bypass
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinica Gastrobese
GERD
Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication
This is a long-term follow-up of a prospective randomized trial comparing open and laparoscopic Nissen fundoplication.
- Trial name
- NCT01230944
- Testing
- Laparoscopic Nissen fundoplication, Open Nissen fundoplication
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
GERD, Sleeve Gastrectomy
An Investigation of Electrical Stimulation on Gastroesophageal Reflux Disease (GERD) in Patients After Sleeve Gastrectomy
Sleeve gastrectomy (SG) has gained popularity as both a staged and a definitive procedure for morbid obesity due to its technical simplicity, low-morbidity and excellent results both for weight loss and control of metabolic…
- Trial name
- NCT02210975
- Testing
- LES-Stimulation Device
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Non-erosive Reflux Disease (NERD)
Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)
This multicenter study aims to evaluate whether Transcutaneous Electrical Acustimulation (TEA) is effective in treating Non-Erosive Gastroesophageal Reflux Disease (NERD).
- Trial name
- NCT07572708
- Testing
- Transcutaneous Electrical Acustimulation
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Gastroesophageal Reflux
Efficacy of Dexlansoprazole MR on Heartburn Control in Participants Previously Receiving Twice Daily Proton Pump Inhibitor Therapy
The purpose of this study is to determine if patients with well-controlled heartburn symptoms on twice-daily proton pump inhibitor therapy remain well-controlled after stepping down to once-daily (QD) dexlansoprazole modified…
- Trial name
- NCT00847808
- Testing
- Dexlansoprazole MR QD
- Where
- 52 sites in United States
- Volunteers
- 178 people
- Sponsor
- Takeda
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