Clinical trials: Esophageal Stenosis
Esophageal Strictures
Cohort Study on the Use of the BOUGIE CAP™ Device for the Treatment of Benign and Short Esophageal Strictures
Benign esophageal strictures are a common condition with multiple and varied causes. Esophageal strictures are manifested by the appearance of dysphagia, usually when the reduction in the esophageal lumen is greater than 50%.
- Trial name
- BOUGIE CAP™ (NCT07534800)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Mitral Prosthetic Valve Stenosis and Regurgitation
Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV)
Transcatheter valve-in-valve implantation has emerged as a valid alternative to redo surgery for patients with surgical bioprosthetic dysfunction.
- Trial name
- SURVIV (NCT04402931)
- Testing
- Transcatheter Valve-in-Valve Intervention, Redo Mitral valve surgery
- Where
- 7 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Superficial Esophageal Cancer
A Study to Evaluate the Esophageal Stenosis Inhibition Effects of CLS2702C/CLS2702D After Endoscopic Submucosal Dissection (ESD) in Patients With Superficial Esophageal Cancer in the Steroid Administration Risk Group
The purpose of this study is to evaluate the efficacy and safety of esophageal epithelial regenerative treatment by the transplantation of the product, CLS2702C, to the esophageal wound site after extensive ESD for superficial…
- Trial name
- NCT04689594
- Testing
- CLS2702C/CLS2702D
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- CellSeed Inc.
Oesophageal Cancer, Esophageal Stent Stenosis
Esophageal Multisegmented FCSEMS for Malignant Strictures
Objective: To assess the safety and feasibility of the implementation of the esophageal multisegmented fully covered self-expandable metal stent (SEMS) for the palliation of patients with malignant dysphagia.
- Trial name
- EATERS (NCT04415463)
- Testing
- Multisegmented fully covered self-expandable metal stent
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Eosinophilic Esophagitis
Fibrostenotic Eosinophilic Esophagitis: Assessment Tools
This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis (EoE) is characterized by abnormal esophageal structure and compliance compared to non fibrostenotic EoE and that distinctive cellular and…
- Trial name
- NCT02453126
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Refractory Anastomotic Esophageal Strictures
WallFlex Esophageal Fully Covered (FC) Benign Anastomotic Stricture
The purpose of this of this study is to compare the safety and effectiveness of temporary indwell of the WallFlex Esophageal FC Metal Stent to Bougie Dilation for the treatment of refractory anastomotic esophageal strictures
- Trial name
- E7025 (NCT01699542)
- Testing
- WallFlex Esophageal RX Fully Covered Stent, Esophageal Bougie Dilator Per Investigator preference
- Where
- 4 sites in Brazil, Netherlands and 1 more
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Esophageal Cancer, Cancer of Gastro Esophageal Junction
Treatment of Malignant Strictures in Esophagus and Gastroesophageal Junction With Covered or Partially Covered Stent.
Self expandable stent (SEMS) constitutes the main palliative treatment in advanced esophageal cancer. The palliative effect of SEMS is immediate when it comes to relief of dysphagia.
- Conditions
- Esophageal Cancer, Cancer of Gastro Esophageal Junction, Palliative Treatment
- Trial name
- StentMig (NCT02166320)
- Testing
- Partially covered SEMS, Fully covered SEMS
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
Esophageal Stenosis, Esophageal Dilation
An Innovative Endoscopic Cap for Dilating Benign Esophageal Strictures in Children
The goal of this study is to find out if using the BougieCap device is a safe and effective way to stretch narrow areas in the esophagus (food pipe) in children.
- Trial name
- BOUGIE-PED (NCT06675825)
- Testing
- BougieCap, Savary-Bougie (A) or balloon dilation (B)
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital, Zurich
Esophageal Strictures, Esophageal Leak
Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment
Esophageal stents are commonly used for benign esophageal pathology, especially strictures or esophageal mucosal defects such as leaks, fistulae, or perforations.
- Conditions
- Esophageal Strictures, Esophageal Leak, Esophageal Perforation, Esophageal Fistula
- Trial name
- NCT02751333
- Testing
- FCSEMS with Endostitch (ES), FCSEMS with No Suturing (NS), Fully Covered Self-Expanding Metal Stents (FCSEMS)
- Where
- United States
- Sponsor
- Johns Hopkins University
Mitral Valve Stenosis With Incompetence or Regurgitation
The Effects of Levosimendan During Mitral Valve Surgery
The effects of levosimendan on renal function in patients with low ejection fraction undergoing mitral valve surgery will be investigated in a prospective, double-blinded, randomized clinical trial using serum creatinine…
- Trial name
- NCT01969071
- Testing
- Levosimendan, Dobutamine
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Benign Esophageal Stricture
Progressive Esophageal Dilation for Benign Strictures: a Randomized Controlled Trial
A randomized controlled prospective clinical trial assessing the efficacy and safety of progressive esophageal dilation compared to conservative esophageal dilation in patients with severe benign esophageal strictures.
- Trial name
- DILATE (NCT03192098)
- Testing
- Savary bougie dilation
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Caustic Esophageal Injury, Esophageal Stenosis
Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management
The management of patients who have ingested a caustic product has changed since 2007. Whereas previously the lesion assessment and surgical indication were based on endoscopic data, the therapeutic algorithm is currently based…
- Conditions
- Caustic Esophageal Injury, Esophageal Stenosis, Pharyngeal Stenosis
- Trial name
- CORTICAU (NCT03760354)
- Testing
- Methylprednisolone
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Disorder, Esophageal Diseases
Role of Topical Steroid Injection With Refractory Benign Esophageal Stricture Endoscopic Dilatation in Children
This clinical trial study included 21 children with refractory benign esophageal strictures. Upper GI endoscopy performed up to the area of stricture, esophageal dilatation done, endoscopy repeated, and steroid injected…
- Conditions
- Pediatric Disorder, Esophageal Diseases, Esophageal Stricture
- Trial name
- ISIs (NCT06514079)
- Testing
- Esophageal dilatation with steroids injection
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Mohammad Daboos
Valvular Heart Disease Stenosis and Regurgitation
Different Methods of Cardiac MRI in Assessment of Estimated Corrected Ejection Fraction in Valvular Heart Diseases
Comparative study between Phase Contrast , Modified Simpson Rule and Myocardial Strain Analysis methods of Cardiac Magnetic Resonance Imaging in assessment of Corrected Estimated Ejection Fraction in Valvular Heart Disease To…
- Trial name
- NCT05808465
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Esophageal Stenosis in Children
Biliary Stent For Management Of Esophageal Stricture In Children
All patients will subjected to the followings: patients were selected by randomization method, full history taking, Complete physical examination, laboratory investigations (complete blood picture, liver and kidney functions…
- Trial name
- NCT07373522
- Testing
- endoscopic stenting of esophageal stricture by fully covered self expanding metallic stent
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Zagazig University
Stent Migration, GastroEsophageal Cancer
Anti-Migration System for Anti-reflux Oeso-gastric Stent (ANTIMIG)
The aim of this prospective, controlled, randomized, multicentre, single-blind study is to compare the rate of intragastric migration of 2 types of esophageal stents with and without an anti-migration device placed for locally…
- Trial name
- ANTIMIG (NCT05431738)
- Testing
- Gastroesophageal stent placement
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Société Française d'Endoscopie Digestive
Refractory Benign Esophageal Strictures
Early Versus Late Endoscopic Stenting for Refractory Benign Esophageal Strictures
This project is being done to compare two current treatment clinical options for management of RBES: 1) Frequent dilations followed by temporary esophageal stent placement if dilations fail, or 2) Early stent placement followed…
- Trial name
- RBES (NCT06991049)
- Testing
- Fully covered self-expandable metal esophageal stent
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Esophageal Cancer
Clinical Efficacy and Safety of Endoscopic Dilatation With Eso-Filp in Benign Esophageal Strictures
Benign esophageal strictures are frequently seen in endoscopic practice and are caused by a variety of esophageal disorders, including peptic, radiotherapy-induced and caustic injuries, Schatzki ring, eosinophilic esophagitis…
- Trial name
- ESO-FLIP (NCT05725473)
- Testing
- Eso-Flip
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Dysphagia
Randomized Controlled Trial of Endoscopic Dilation: Triamcinolone Injection
The purpose of this pilot study is to find out if adding triamcinolone (steroid) injection at the participant's initial esophagogastroduodenoscopy (EGD) procedure will improve the opening of their esophagus and decrease the need…
- Trial name
- NCT01873573
- Testing
- Dilation, Triamcinolone Injection, Esophagogastroduodenoscopy (EGD)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Esophageal Neoplasms, Constriction
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02937389
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Nagasaki University