Clinical trials: Esophagitis, Peptic
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Gastroesophageal Reflux Disease With Esophagitis
PPI Dosing Per CYP2C19 Genotype
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication…
- Trial name
- NCT07843264
- Testing
- CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Gastroesophageal Reflux Disease, Hiatal Hernia
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication
Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Esophagitis, Peptic, Barrett Esophagus
- Trial name
- NCT07809620
- Testing
- Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication
- Where
- Egypt
- Volunteers
- 470 people
- Sponsor
- Minia University
Gastric Adenocarcinoma, Adenocarcinoma of the Esophagogastric Junction
Sino-Russian Comparison of Outcomes After Proximal Gastrectomy With Double-Tract Reconstruction
This two-center retrospective observational cohort study compares Chinese and Russian patients who underwent curative proximal gastrectomy with double-tract reconstruction for proximal gastric adenocarcinoma or Siewert type…
- Trial name
- RUSCHI-DTR (NCT07800819)
- Testing
- Proximal gastrectomy with double-tract reconstruction
- Where
- 2 sites in China, Russia
- Volunteers
- 250 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy
The goal of this observational study is to learn whether bile acids and pepsin in saliva can help identify adults at higher risk of developing reflux-related esophageal disease after sleeve gastrectomy, including Los Angeles…
- Conditions
- Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy, Saliva Collection, Reflux Esophagitis (RE)
- Trial name
- ABSORB (NCT07607067)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Obesity, Roux-en-y Anastomosis Site
FundoRing Roux-en-Y Gastric Bypass Versus FundoRing One Anastomosis Gastric Bypass
Metabolic and bariatric surgery (MBS) is an effective and durable treatment of severe obesity and its co-morbidities. Gastric bypass is one of the main MBS procedures and is performed using various surgical techniques.
- Conditions
- Obesity, Roux-en-y Anastomosis Site, Reflux Gastritis, Reflux Esophagitis
- Trial name
- FundoRing_RY (NCT07486765)
- Testing
- Laparoscopic FundoRing gastric bypass
- Where
- Kazakhstan
- Volunteers
- 200 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Reflux Esophagitis, Gastric Ulcer
A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
This is an open label, parallel group, multi-centre, phase III study to assess the safety and efficacy of D961H in maintenance therapy following initial healing therapy in Japanese paediatric patients with reflux esophagitis, and…
- Conditions
- Reflux Esophagitis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT03553563
- Testing
- D961H capsule 10mg, D961H sachet 10mg
- Where
- 15 sites in Japan
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
Achalasia, Esophageal, GERD (Gastroesophageal Reflux Disease)
Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief.
- Trial name
- SFP-POEM (NCT07178821)
- Testing
- Conventional POEM, Sling Fiber-Preserving POEM
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Reflux Esophagitis (RE)
A Clinical Trial of Anaprazole for Treating Reflux Esophagitis.
This Phase III clinical trial is designed to assess the efficacy and safety of Anaprazole 60 mg once daily (QD) administered over a period of up to 8 weeks, compared with Rabeprazole 20 mg QD, in patients with reflux esophagitis.
- Trial name
- NCT07010107
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Reflux Esophagitis
The Phase III Clinical Trial of X842 Capsules for Reflux Esophagitis
To evaluate the efficacy and safety of X842 Capsules 50 mg compared to Lansoprazole Enteric Capsules for the treatment of reflux esophagitis, and to characterize the population pharmacokinetics of X842 capsules in this patient…
- Trial name
- X842 (NCT07079540)
- Testing
- X842, Lansoprazole
- Where
- 53 sites in China
- Volunteers
- 380 people
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Reflux Esophagitis
Study to Evaluate the Safety and Efficacy of X842 in Patients With Reflux Esophagitis
The purpose of the study is to investigate the efficacy and dose-effect relationship of X842 capsules at different dosages in the treatment of reflux esophagitis for 4 weeks in comparison with lansoprazole enteric-coated capsules.
- Trial name
- NCT04531475
- Testing
- X842, Lansoprazole
- Where
- 16 sites in China
- Volunteers
- 90 people
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Reflux Esophagitis
Special Drug Use Surveillance of Vonoprazan for "Maintenance Therapy of Reflux Esophagitis: Long-term Use"
The purpose of this survey is to evaluate the safety and effectiveness of long-term administration of vonoprazan tablets when used as maintenance therapy for reflux esophagitis in routine clinical settings.
- Trial name
- NCT03214081
- Testing
- Vonoprazan
- Where
- Japan
- Volunteers
- 1,237 people
- Sponsor
- Takeda
Stomach Neoplasms
Feasibility and Safety of Robotic Assisted Proximal Gastrectomy With Double-flap Technique for Proximal Early Gastric Cancer
Proximal early gastric cancer can choose radical total gastrectomy or proximal gastrectomy. The patients have poor nutritional status and quality of life after total gastrectomy.
- Trial name
- NCT05892289
- Testing
- Robotic assisted proximal gastrectomy with double-flap technique
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Reflux Esophagitis (RE)
A Phase III Clinical Trial for Efficacy and Safety Evaluation of JP-1366 Tablets on Reflux Esophagitis
To evaluate the efficacy and safety of JP-1366 tablets and Nexium® (Esomeprazole magnesium enteric-coated tablets) in subjects with reflux esophagitis.
- Trial name
- NCT06850480
- Testing
- JP-1366 simulation tablets, Esomeprazole Magnesium (Nexium) simulation tablets
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Gastric Cancer, Reflux Esophagitis
Preliminary Efficacy Analysis of "C" Single Flap Plasty Reconstruction After Laparoscopic Proximal Gastrectomy
The incidence of proximal gastric cancer has increased significantly in recent years. This may be due to weight gain, alcohol consumption, gastroesophageal reflux disease (GERD), and precancerous lesions.
- Trial name
- NCT06741501
- Testing
- "C" Single Flap Plasty Reconstruction, Normal Reconstruction
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Daorong Wang
Gastric Cancer, Reflux Esophagitis
Preliminary Efficacy Analysis of 'λ+α' Double-Tract Reconstruction After Laparoscopic Proximal Gastrectomy
The incidence of proximal gastric cancer has increased significantly in recent years. This may be due to weight gain, alcohol consumption, gastroesophageal reflux disease (GERD), and precancerous lesions.
- Trial name
- NCT06475170
- Testing
- proximal gastrectomy combined with 'λ+α' double-tract anastomosis
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Northern Jiangsu People's Hospital
Reflux Disease, Gastro-Esophageal, Hiatal Hernia
Treatment of Reflux With Sleeve Gastrectomy
In 2008, the World Health Organization (WHO) report found that 0.5-1.5 billion people aged 20 years and above suffer from overweight (body mass index (BMI) ≥ 25) and obesity (BMI ≥ 30 kg / m2) stated.
- Conditions
- Reflux Disease, Gastro-Esophageal, Hiatal Hernia, Reflux Esophagitis
- Trial name
- NCT06170060
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yusuf Emre ALTUNDAL