Clinical trials: Etiology
Acute Respiratory Distress Syndrome, COVID19 Infection
Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection
It is a multicenter, national, randomized 1:1 ratio, controlled, parallel, open study. Patients with severe ARDS-CoVid19 will be included in the trial within the first 24 hours.
- Trial name
- SEVO-COVID19 (NCT04359862)
- Testing
- Sevoflurane, Propofol
- Where
- 5 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Spasticity, Spasticity in Participants With Multiple Sclerosis
Nerve Root Block in Spasticity
In this work the investigators propose to briefly apply kilohertz frequency alternating current via PNS device placed next to the isolated nerve in 4 patients undergoing peripheral neurectomy, just before cutting the nerve.
- Conditions
- Spasticity, Spasticity in Participants With Multiple Sclerosis, Spasticity Post Stroke, Spasticity Related to Any Cause Except Cerebral Palsy
- Trial name
- NCT06868342
- Testing
- High-frequency nerve conduction block
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Walton Centre NHS Foundation Trust
Skin Toxicity in Patients on Checkpoint Inhibitors
"Evaluation of a Non-Pharmacological Skin Care Intervention for the Prevention and Treatment of Skin Toxicities Caused by Immunotherapy in Cancer Patients"
Due to recent approvals, a significant number of adult cancer patients are undergoing treatment with checkpoint inhibitor antibodies.
- Trial name
- NCT07337486
- Testing
- Shea Butter and Niacinamide, Argan Oil and Coconut Butter
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Radiodermatitis
Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.
The study cream is to be evaluated in a multicenter, randomized, controlled clinical study carried out in 2 hospitals, in the Radiation Oncology service of Valencia to evaluate its radioprotective and radiomitigation effect in…
- Trial name
- RADIOCREMVAL (NCT05886673)
- Testing
- experimental cream, standard of care
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Antonio J. Conde Moreno
Acute Low Back Pain, Physical Activity
Acute Low Back Pain: Causes, Mechanisms, Treatment and Followup
The purpose of this study is to investigate acute low back pain, its origin, mechanisms, the cause of pain, evaluation of treatments and development.
- Trial name
- ALBP (NCT02517762)
- Testing
- Physical activity
- Volunteers
- 99 people
- Sponsor
- Göteborg University
Epilepsy, Cryptogenic Epilepsy
S100B Protein: a Diagnostic Aid in Episodes of Transient Loss of Consciousness?
S100B protein is a biomarker produced mainly by astrocytes and released into the bloodstream in the event of brain injury, with levels rising rapidly and markedly in acute conditions such as traumatic brain injury, stroke, or…
- Trial name
- EPILEPSY (NCT07527754)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Pneumonia Caused by Multidrug-resistant Gram-negative Bacterial Infection
A Study on Integrated Chinese and Western Medicine for Severe Pneumonia Caused by Multidrug-Resistant Gram-Negative Bacterial Infections
This study aims to evaluate the clinical efficacy of a traditional Chinese medicine formula granule (Feireqing Granules) in the treatment of severe pneumonia caused by multidrug-resistant Gram-negative bacterial infections…
- Trial name
- NCT07206745
- Testing
- Fei Re Qing Granules
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Henan University of Traditional Chinese Medicine
HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine
Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome
Primary liver cancer is a malignant tumor with a very poor prognosis. Hepatocellular carcinoma(HCC) accounts for approximately 80% of cases.
- Conditions
- HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine, ICG (Indocyanine Green), Overall Survival (All-cause Mortality)
- Trial name
- DAWNbreak-120 (NCT07691645)
- Testing
- Shuganhuazhuo Formula, Targeted therapy, Immunotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiang-Qian
Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had: an acute stroke due to a blood clot that formed outside the…
- Conditions
- Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack
- Trial name
- OCEANIC-STROKE (NCT05686070)
- Testing
- Asundexian (BAY2433334)
- Where
- 741 sites in United States, Argentina and 35 more
- Volunteers
- 12,327 people
- Sponsor
- Bayer
Meniscus Tear Caused by a Traumatic Event, Fibrin Clot Augmentation
A Comparative Prospective Study of the Arthroscopic Meniscal Repair Methods
Performing arthroscopic meniscus repair following a traumatic meniscus tear as an alternative to a meniscectomy is now an acceptable choice.
- Conditions
- Meniscus Tear Caused by a Traumatic Event, Fibrin Clot Augmentation, Meniscal Repair
- Trial name
- NCT06176183
- Testing
- Arthroscopic meniscus repair
- Where
- 2 sites in Lithuania
- Volunteers
- 100 people
- Sponsor
- Vilnius University
COVID-19, SARS-CoV-2 Acute Respiratory Disease
Immunogenicity and Safety of a Booster Vaccination With a Recombinant Protein RBD Candidate Vaccine Against SARS-CoV-2 in Healthy Adults Volunteers Fully Vaccinated Followed by an Extension Period to Study a Fourth Dose Administration.
This Phase IIb clinical study aims to compare the immunogenicity and safety of a booster dose of recombinant protein RBD fusion dimer vaccine as a heterologous booster (to subjects who have received the second dose of the…
- Trial name
- NCT05142553
- Testing
- COVID-19 Vaccine HIPRA, Cominarty (Pfizer-BioNtech)
- Where
- 10 sites in Spain
- Volunteers
- 887 people, healthy volunteers welcome
- Sponsor
- Hipra Scientific, S.L.U
Infant, Pain
Kangaroo Care Reduces Infant Pain Caused By Vaccination
The aim of this randomized controlled study determine the effect of KMC on pain in infants during vaccination.
- Conditions
- Infant, Pain, Kangaroo Mother Care, Nursing
- Trial name
- NCT04596137
- Testing
- İnfant pain management
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Cerebral Infarction
Early Neurological Deterioration in Patients With Acute Ischemic Stroke
This study set out to explore the risk factors of early neurological deterioration (END) occurred in patients with acute ischemic stroke and to investigate the corresponding predictors.
- Trial name
- ENDAIS (NCT03703986)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Delayed;Development;Physical, Delayed; Development, Intellectual
Etiology of Motor Developmental Delay in Children
This study aims to identify the etiology of children with motor developmental delay, in association with the results of magnetic resonance imaging and genetic analysis.
- Trial name
- MDD (NCT03130972)
- Volunteers
- 1,355 people
- Sponsor
- Bundang CHA Hospital
Pain Score
Prevention of Pain Caused by the Oro-gastric Tube Laying in Neonatology
Subject of research : Evaluation of a technique of care to reduce the pain caused by the laying of the gastric tube in the newborn
- Trial name
- DOLATSONG (NCT03142230)
- Testing
- the laying of the gastric tube and a group using the holed baby bottle nipple, the feeding tube ideally positioned at the center of the intersection pharyngeal, the laying of the gastric tube and a group with simple non-nutritive suction, the feeding tube passing next to the newborn's personal pacifier
- Where
- 3 sites in France
- Volunteers
- 71 people
- Sponsor
- Centre Hospitalier Sud Francilien
Onychomycosis of Toenail, Onychomycosis
Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)
A study to determine if a three-treatment protocol with the RenewalNail™ plasma treatment system over a week will result in mycological cure and/or clear nail growth on the treated hallux toe.
- Trial name
- NCT03216200
- Testing
- plasma treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DeviceFarm, Inc.
Inflammatory Bowel Diseases, Proctosigmoiditis
Role of FCI in the Detection of Proctosigmoiditis Caused by IBD
The goal of this pilot study is to explore the ability of field-cycling imaging, a new scanning technology being developed at the University of Aberdeen, to detect active disease in patients with proctosigmoiditis caused by…
- Trial name
- ROOFTOPS-IBD (NCT05817266)
- Testing
- Field-cycling imaging (FCI)
- Where
- United Kingdom
- Sponsor
- NHS Grampian
Pain
A Registry Study to Evaluate Outcomes of PEMF Therapy in Subjects With Various Pain Etiologies
The study is an open-label, non-controlled study of the safety and effectiveness of investigator determined Provant therapy in subjects with pain and/or edema from various pain etiologies.
- Trial name
- NCT02881112
- Testing
- Provant Therapy System
- Where
- 8 sites in United States
- Volunteers
- 180 people
- Sponsor
- Regenesis Biomedical, Inc.
Dyspnea Caused by 2019-nCoV
Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study)
The aim of this research is to evaluate an innovative treatment, Bevacizumab, in patients suffering from respiratory complications related to COVID-19.
- Trial name
- BASECOVID (NCT07089719)
- Testing
- Bevacizumab Injection
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Candidiasis, Invasive, Candidemia
Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES)
This is a multicenter, open-label, non-comparator, single-arm study to evaluate the efficacy, safety, tolerability and PK (pharmacokinetics) of oral SCY-078 as an emergency use treatment for patients with a documented Candida…
- Trial name
- CARES (NCT03363841)
- Testing
- SCY-078
- Where
- 12 sites in United States, India and 2 more
- Volunteers
- 30 people
- Sponsor
- Scynexis, Inc.
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