Clinical trials: Etiology
Undiagnosed Disease
Exome and Genome Analysis to Elucidate Genetic Etiologies and Population Characteristics in the Plain Community
This study is designed to utilize whole exome and whole genome sequencing techniques to identify underlying genetic causes for undiagnosed disorders in the Plain Communities, and to do population genetic studies looking at…
- Trial name
- NCT02927158
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Severe Acute Respiratory Syndrome
Prevalence of Antibodies Against SARS-CoV-2 Virus That Causes COVID-19 in Tübingen Children
This is a prospective, longitudinal study to determine the incidence of SARS-COV-2 infection in children and adolescents by measuring specific antibodies in non-invasive saliva sampled in kindergartens and schools in a defined…
- Trial name
- Coro-Buddy (NCT04581889)
- Testing
- Diagnostic test
- Where
- Germany
- Volunteers
- 2,380 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Breast Cancer, Endometrial Cancer
Extended Follow-up of Columbia, MO Serum Bank Participants
The Columbia, MO Serum Bank initially was established in 1977 as part of the National Cancer Institute's (NCI) Biological Markers Project to identify serum markers for breast cancer.
- Conditions
- Breast Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00340210
- Where
- United States
- Volunteers
- 6,720 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Brain and Central Nervous System Tumors, Seizure
Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases
RATIONALE: Anticonvulsant drugs, such as levetiracetam, may help control seizures caused by brain metastases. PURPOSE: This clinical trial is studying the side effects and how well levetiracetam works in treating patients with…
- Conditions
- Brain and Central Nervous System Tumors, Seizure, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00415376
- Testing
- levetiracetam, quality-of-life assessment
- Sponsor
- Northwestern University
Brain Edema Caused by Drugs, Cerebral Oxygenation
Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome
The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor's underlying pathophysiology including brain…
- Trial name
- TIVolBrain (NCT06779890)
- Testing
- Sevoflurane, Desflurane
- Where
- 2 sites in Greece
- Volunteers
- 84 people
- Sponsor
- Georgia Tsaousi
Pruritus
Gabapentin for the Treatment of Pruritus Caused by Burn Injuries in Children
Children with healing burns often suffer from pruritus that may continue for many months. Pruritus can be very distressing to the child and can interfere with sleep, activities of daily living, and rehabilitation therapy.
- Trial name
- NCT01092520
- Testing
- Gabapentin
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Venous Thromboembolism
Follow-up in Rivaroxaban Patients in Setting of Thromboembolism
In patients with acute clots (deep vein thrombosis or pulmonary embolism) the investigators will collect real world data on their short and long term outcomes.
- Trial name
- FIRST (NCT02248610)
- Testing
- Non-interventional study
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,343 people
- Sponsor
- King's College Hospital NHS Trust
Rabies in Animals, Worms; Intestine
Integrating Community Interventions to Eliminate Neglected Tropical Diseases
The overarching goal of this project is the elimination of two neglected tropical diseases (NTD): soil-transmitted helminthiasis and rabies.
- Trial name
- NCT03667079
- Testing
- integrated delivery of deworming and vaccination, Mass deworming only, Mass vaccination of dogs
- Where
- United States
- Volunteers
- 28,143 people, healthy volunteers welcome
- Sponsor
- Washington State University
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Left Ventricular Mass Index Predicts Clinical Outcomes in Patients with Obstructive Hypertrophic Cardiomyopathy Undergoing Septal Myectomy
In this study, we aimed to analyze the association between left ventricular mass index and clinical outcomes to provide the potential indicator for worse survival.
- Trial name
- LVMI and oHCM (NCT06609382)
- Testing
- Patients had a higher left ventricular mass index or not （the exact value is determined by the cut-off value for the clinical outcomes)
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Changrong Nie
Anorexia Nervosa Restricting Type, Anorexia Nervosa (DSM-IV Revised Criteria)
Biomarkers in EV Associated With Marrow Adiposity in Anorexia
The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa.
- Trial name
- VE_BMAT_AN (NCT06712485)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Neural Tube Defects, Bisphenol-A
Could Bisphenol-A Have a Role in the Etiology of Neural Tube Defects
Our aim in this study is in patients with a diagnosis of neural tube defect; is the measurement of BPA levels in maternal blood and amniotic fluid.
- Trial name
- NCT05454085
- Testing
- Bisphenol-A
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
COVID, Covid-19
A Study of ResCure™ to Treat COVID-19 Infection
This is a Phase I open-label interventional study which will test the efficacy of ResCure™ in the treatment of patients with COVID-19 infection.
- Conditions
- COVID, Covid-19, Corona Virus Infection, Sars-CoV2
- Trial name
- NCT04395716
- Testing
- ResCure™
- Where
- United States
- Sponsor
- ProgenaBiome
Torsades de Pointe Caused by Drug
A Pharmacovigilance Study of Torsade de Pointes
Many cardiac and non-cardiac drugs are associated with TdP that may constitute a significant problem because of sudden cardiac death.
- Trial name
- NCT04293432
- Testing
- Drugs, Generic
- Where
- Pakistan
- Volunteers
- 6,670 people
- Sponsor
- University of Peshawar
Ear Deformities, Acquired, Ear; Deformity, Congenital
Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures
This study evaluates the efficacy of the AuryzoN devices in the ear and nose reconstruction surgeries, both in terms of operative time and overall quality of reconstruction.
- Conditions
- Ear Deformities, Acquired, Ear; Deformity, Congenital, Microtia, Nose Deformity
- Trial name
- NCT03624608
- Testing
- AuryzoN Family of Devices
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Reconstrata, LLC
Anastomotic Leaks
Observational Analysis of the Cause of Leaks When Bowel is Cut and Reconnected
The purpose of this study is to identify the cause of leaks that sometimes occur after a section of the bowel is removed and reconnected.
- Trial name
- NCT02178228
- Where
- United States
- Volunteers
- 1,077 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychological Stress
The Effectiveness of Pharmacopuncture on Psychological Stress
This study is a double blind, randomized controlled trail. Condition/disease: Psychological Stress treatment Intervention:Pharmacopuncture
- Trial name
- NCT06107777
- Testing
- Pharmacopuncture, Korean medical treatment
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Jaseng Medical Foundation
Overactive Bladder
Pilot Study: Is Overactive Bladder Caused by Subacute Urinary Tract Infections?
The purpose of this study is to look for evidence of bacteria in the urine or bladder of people with overactive bladder. Because you do not have overactive bladder, your participation in this study will be used as a comparison to…
- Trial name
- NCT00714792
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Small Bowel Perforations
Retrospective Analysis on Small Bowel Perforations
A retrospective, monocentric, code-related data analysis of patients with small bowel perforations was performed for the period 2010 to 2019.
- Trial name
- SBP (NCT05471999)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- University Hospital Tuebingen
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