Clinical trials: Etiology
Osteoarthritis, Meniscus Lesion
A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.
Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and…
- Trial name
- NCT06707948
- Testing
- Arthroscopic meniscus surgery
- Volunteers
- 69 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Corneal Abrasion
Short Term Topical Tetracaine is Safe and Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions
The objective of this study was to show that patients with corneal abrasions would experience more pain relief with short term topical tetracaine than placebo, have similar complication rates, and take less hydrocodone for…
- Trial name
- NCT04187417
- Testing
- topical tetracaine hydrochloride 1%
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- INTEGRIS Southwest Medical Center
Critical Care, Infection
Real-world Multicentre Study of AZtreonam-AVIbactam Treatment With Infections or Suspected Infections Caused by Multidrug-resistant Gram-negative Bacteria
The AZAVI study is a multicenter observational registry (ICU and Infectious Diseases departments), designed to evaluate the real-world use of aztreonam-avibactam for suspected or documented infections caused by…
- Conditions
- Critical Care, Infection, Antibiotic Resistance, Infectious Diseases
- Trial name
- AZAVI (NCT07176247)
- Testing
- Aztreonam-Avibactam
- Where
- France
- Volunteers
- 100 people
- Sponsor
- French Society for Intensive Care
Entamoeba Histolytica Diarrhea
Nitazoxanide vs Metronidazole for Entamoeba Diarrhea in Children
This randomized controlled trial is comparing two medicines, nitazoxanide and metronidazole, for the treatment of diarrhea caused by Entamoeba histolytica in children.
- Trial name
- NIT MET (NCT07790926)
- Testing
- Nitazoxanide, Metronidazole
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Burns, Bone Demineralization
Evaluation of Vitamin D Status in Children With Acute Burns
To see which vitamin D supplement (D2 vs D3) is most beneficial in burned children.
- Trial name
- VitaminD (NCT00536276)
- Testing
- Vitamin D2, Vitamin D3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shriners Hospitals for Children
Pulmonary Fibrosis
Supplemental Oxygen in Pulmonary Fibrosis
To enhance understanding of supplemental oxygen-its utility in and adoption by patients with pulmonary fibrosis-by examining how patients perceive it and by determining how perceptions and patient-centered outcome measures change…
- Trial name
- NCT01961362
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Oneida Nation Members
Brain Health Oneida
The purpose of this observational study is to better understand the relationship between stroke risk factors and brain MRI measures in the Native American population.
- Trial name
- NCT07080866
- Testing
- MRI, Carotid ultrasound
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Wisconsin, Madison
Locked-In Syndrome；Pulmonary Arteriovenous Malformation
Locked-in Syndrome Caused by Pulmonary Arteriovenous Malformation: A Case Report
In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM).
- Trial name
- NCT05348902
- Testing
- In this study, only cases were collected and reported without any intervention or adverse reactions
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aneurysmal Subarachnoid Hemorrhage
EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route ("Tuohy-drain") will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- EARLYDRAIN (NCT01258257)
- Testing
- Insertion of a lumbar drain
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Clubfoot
Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI
The purpose of this study is to: 1. compare structural variations observed in the calf and foot of the clubfoot mouse model(pma)with human clubfoot patients antenatally and postnatally; 2.
- Trial name
- NCT01088828
- Testing
- Magnetic Resonance Imaging (MRI) of calf and foot
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Fetuses With at Least 2 Malformations, and no Diagnosis After Fetopathological and Radiological Examinations
Contribution of High-throughput Exome Sequencing in the Diagnosis of the Cause Fetal Polymalformation Syndromes
This research concerns the contribution of a new examination, high-throughput exome sequencing, in the diagnosis of the cause of polymalformative fetal syndromes.
- Trial name
- FOETEX (NCT02512354)
- Testing
- Sample of a fragment of fetal tissue, Parent's blood samples
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Child Poverty
Cash Transfers to Address Child Welfare Involvement
In partnership with New York Office of Child and Family Services (OCFS), investigators will execute a randomized controlled trial to determine the impacts of unconditional cash transfers of $500 per month for 12 months.
- Trial name
- NCT05857553
- Testing
- Unconditional Cash Transfer, No Direct Cash Transfer
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease
Clopidogrel Resistance and the Possibility of Its Affection
The purpose of the study is to determine, whether the resistance to clopidogrel could be affected by higher doses of this drug, or by replacement of clopidogrel with another ADP-antagonist ticlopidine.
- Trial name
- NCT00839345
- Testing
- clopidogrel
- Where
- Czechia
- Sponsor
- Charles University, Czech Republic
Meningitis
Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda
This study will investigate the burden, causes, diagnostics, treatments and preventive measures related to meningitis in northern Uganda.
- Trial name
- NCT05496673
- Testing
- Pastorex Latex Agglutination Test, Biofire PCR for meningitis, Immy CrAg Lateral Flow Assay
- Where
- Uganda
- Volunteers
- 11,100 people
- Sponsor
- University of Rochester
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban Estimation With Warfarin in Atrial Fibrillation Patients With Coronary Stent Implantation Study (REWRAPS)
Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Stroke, Fetal Blood Loss
- Trial name
- REWRAPS (NCT02024230)
- Testing
- Rivaroxaban or Warfarin
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Fujita Health University
Sinus Infection
Causes of Non-invasive Fungal Sinusitis as Presented in Sohag University Hospital
in this study, the investigators will collect data from patients with non-invasive fungal sinusitis to know what causes it
- Trial name
- NCT05102539
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University
Deafness Caused by High Grade Microtia or Ear Atresia
OSIA System Bilateral Implantation Efficacy Evaluation in Children With Ear Aplasia
The aim of this study is to compare speech perception in noise with one activated Osia (unilateral) versus two activated Osia (bilateral), in children with high grade microtia/ear atresia fitted with bilateral Osia implants.
- Trial name
- APLOSIA (NCT07358728)
- Testing
- Audiological tests, Speech, Spatial and Qualities of Hearing Scale
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Lupus Erythematosus
Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus
The purpose of this study is to determine whether Libman-Sacks endocarditis (inflammation of the heart valves) is the cause of neuropsychiatric manifestations (stroke, transient ischemic attacks, cognitive dysfunction, seizures…
- Trial name
- NCT00858884
- Testing
- Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Acute Bacterial Skin and Skin-structure Infection(ABSSSI) Due to Staphylococcus Aureus (MSSA), (Susceptible or Methicillin Resistant)
Initial Treatment for Acute Bacterial Skin Infections (ABSSSI) Caused by Staphylococcus Aureus
The study investigates the safety and efficacy of PMX-30063 in patients treated for acute bacterial skin and skin-structure infection (ABSSSI).
- Trial name
- NCT01211470
- Testing
- Daptomycin, PMX-30063-investigational drug
- Where
- 8 sites in Canada, Russia and 1 more
- Volunteers
- 215 people
- Sponsor
- PolyMedix, Inc.
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