Clinical trials: Etiology
Hypertension, Pregnancy-Induced, Hypertension
Wearables to Define Postpartum Blood Pressure Trajectories and Facilitate Evidence-based Monitoring Guidelines
To better understand postpartum blood pressure changes, the investigators are proposing a study to monitor blood pressure after delivery in 100 patients who the investigators expect to have normal blood pressure (i.e.
- Conditions
- Hypertension, Pregnancy-Induced, Hypertension, Postpartum Preeclampsia, Postpartum Complication
- Trial name
- NCT06576544
- Testing
- BP Watch
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, San Diego
HIV Infections, Peripheral Nervous System Disease
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
To evaluate the separate and combined efficacy of a standardized acupuncture regimen and amitriptyline on the relief of pain due to peripheral neuropathy and on the quality of life of HIV-infected patients.
- Trial name
- NCT00000817
- Testing
- Amitriptyline hydrochloride, Point acupuncture
- Where
- 11 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of ART5803 following IVIG administration in healthy participants to investigate the potential interactions between ART5803 and IVIG
- Conditions
- Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder), Autoimmune Encephalitis
- Trial name
- NCT06753955
- Testing
- ART5803, Intravenous immunoglobulin (IVIG)
- Where
- Australia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Arialys Therapeutics
Neural Tube Defects, Bisphenol-A
Could Bisphenol-A Have a Role in the Etiology of Neural Tube Defects
Our aim in this study is in patients with a diagnosis of neural tube defect; is the measurement of BPA levels in maternal blood and amniotic fluid.
- Trial name
- NCT05454085
- Testing
- Bisphenol-A
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Pneumocystis, Pneumocystis Infection
Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives)
The usual first treatment for Pneumocystis jirovecii pneumonia (PCP) is an antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX).
- Conditions
- Pneumocystis, Pneumocystis Infection, Pneumocystis Carinii Infection, Pneumocystis Carinii; Infection, Resulting From HIV Disease
- Trial name
- SPIRIT-ALT (NCT07357103)
- Testing
- Clindamycin + primaquine, Pentamidine, Atovaquone
- Volunteers
- 416 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Respiratory Distress Syndrome, COVID19 Infection
Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection
It is a multicenter, national, randomized 1:1 ratio, controlled, parallel, open study. Patients with severe ARDS-CoVid19 will be included in the trial within the first 24 hours.
- Trial name
- SEVO-COVID19 (NCT04359862)
- Testing
- Sevoflurane, Propofol
- Where
- 5 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Stroke, Acute, Biological Specimen Banks
Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes.
- Conditions
- Stroke, Acute, Biological Specimen Banks, Biomarkers, Etiology
- Trial name
- COMPO-CLOT (NCT03268668)
- Testing
- Collection of thrombus that is responsible for stroke and blood sample
- Where
- 12 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Pain, Peripheral Neuropathy
MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy
RATIONALE: Scrambler therapy may help relieve pain from peripheral neuropathy caused by chemotherapy. PURPOSE: This phase II trial is studying how well MC5-A scrambler therapy works in reducing peripheral neuropathy caused by…
- Trial name
- NCT01290224
- Testing
- scrambler therapy, questionnaire administration
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Burnout, Mental Health Wellness 1
Mindfulness and Intercare Based Intervention for Physicians Burnout Reduction
During the coronavirus disease 2019 (COVID19) pandemic, many physicians have presented burnout. A range of associated factors need to be considered for effective prevention and intervention.
- Trial name
- MIIB (NCT05013489)
- Testing
- Mindfulness and intercare based intervention
- Where
- Chile
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- University Diego Portales
Zoster; Herpes, Trigeminal Neuralgia (Etiology)
Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia
To assess the 1-month effects and safety of esketamine combined PRF and standardized treatment to relieve pain in patients with acute/subacute zoster-related trigeminal neuralgia(ZRTN).
- Trial name
- NCT06890897
- Testing
- Esketamine group, PRF group
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Beijing Tiantan Hospital
Lumbar Disc Herniation, Annular Disc Tear
A Post Marketing Surveillance Study
This study is a prospective, multi-center study to monitor the early safety and performance of one iteration of the Barricaid Anular Closure Device (ACD) - 6mm anchor width, when used as an adjunct to limited discectomy.
- Conditions
- Lumbar Disc Herniation, Annular Disc Tear, Annular Tear of Lumbar Disc
- Trial name
- 6MM (NCT03366779)
- Testing
- 6mm annular closure device
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 20 people
- Sponsor
- Intrinsic Therapeutics
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Bilateral Hearing Loss for Causes Other Than Tumors
Auditory Brainstem Implant (ABI) in Pediatric Non-Neurofibromatosis Type 2 Subjects
The purpose of this research study is to determine whether Auditory Brainstem Implant (ABI) can improve hearing in children who are deaf and cannot receive a cochlear implants.
- Trial name
- ABI (NCT01864291)
- Testing
- Nucleus 24 (discontinued) and ABI541 Auditory Brainstem Implants (ABI)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Severe Burns
Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns
Burns affect more than 11 million people worldwide each year. These injuries are responsible for severe morbidity resulting in a high societal burden and account for more than 180,000 yearly deaths especially in low- and…
- Trial name
- DEXA-BURN (NCT06968559)
- Testing
- Dexamethasone
- Where
- 10 sites in France
- Volunteers
- 478 people
- Sponsor
- Nantes University Hospital
Infection Due to ESBL Escherichia Coli
Fosfomycin Versus Meropenem or Ceftriaxone in Bacteriemic Infections Caused by Multidrug Resistance in E.Coli
Enterobacterieaceae (and specially Escherichia coli) showing resistance due to multidrug-resistant Escherichia coli, plasmid mediated AmpC or quinolone resistance caused by chromosomal mechanisms have spread worldwide during the…
- Trial name
- FOREST (NCT02142751)
- Testing
- Fosfomycin sodium intravenous, Meropenem intravenous, Ceftriaxone intravenous
- Where
- 22 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Gynecological Tumor, Ovarian Cancer
Prevention and Treatment of CINV Caused by TC Regimen in Gynecological Malignant Tumor Patients
To determine the best method to prevent CINV caused by TC regimen in patients with gynecological malignant tumor. Paclitaxel-carboplatin (TC) is the most widely used regimen for gynecologic malignancies, yet chemotherapy-induced…
- Conditions
- Gynecological Tumor, Ovarian Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT06007586
- Testing
- Aprepitant Injection
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Glaucoma, Suspect, Diabetic Retinopathy
Eye Health Intervention Study in Upper Manhattan
Individuals living in Upper Manhattan have limited access to eye care, high vision impairment rates, and poor ocular health outcomes.
- Conditions
- Glaucoma, Suspect, Diabetic Retinopathy, Cataract, Refractive Errors
- Trial name
- EYES-UM (NCT06112431)
- Testing
- Intervention, Usual Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Anemia
Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire
The proposed project is aimed at testing two interventions, namely a highly bioavailable iron compound and a combination of SP plus amodiaquine for intermittent preventive treatment (IPT) of malaria, to reduce anaemia in very…
- Trial name
- NCT01634945
- Testing
- SP/amodiaquine, FeFum fortified porridge, SP/Amodiaquine + FeFum fortified porridge
- Where
- Côte d’Ivoire
- Volunteers
- 629 people
- Sponsor
- Swiss Federal Institute of Technology
Anemia
Anemia Etiology Evaluation in Ethiopia
The AnemEE study is a population-based anemia etiology survey in six regions of Ethiopia. The primary aim of the study is to evaluate the relative contribution of risk factors for anemia among children, women of reproductive age…
- Trial name
- AnemEE (NCT04002466)
- Testing
- Risk factors for anemia
- Where
- Ethiopia
- Volunteers
- 5,114 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Endosseous Dental Implant Failure, Accident Caused by Broken Ceramic
Full-Contour Monolithic Zirconia Full-Mouth Implant Supported Rehabilitation Behavior
In patients who received a full-mouth implant-supported rehabilitation restored with CAD/CAM full-contour monolithic zirconia (FCMZ, without buccal ceramic veneer; veneering, if present, limited to the gingival area), what is the…
- Trial name
- FCMZ (NCT07876466)
- Testing
- Dental Implant, Monolithic Zirconia (FCMZ)
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
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