Clinical trials: Etiology
Pulmonary Edema Cardiac Cause
HF vs NIV in Acute Cardiogenic Pulmonary Edema
The study's primary aim is to compare the effects of two different ventilation modalities, non-invasive positive-pressure ventilation (NPPV) and high-flow nasal cannulae (HFNC), in the acute cardiogenic pulmonary edema (ACPE)…
- Trial name
- HFvsNIV (NCT05989139)
- Testing
- NPPV/HFNC, HFNC/NPPV
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Psychological Stress
The Effectiveness of Pharmacopuncture on Psychological Stress
This study is a double blind, randomized controlled trail. Condition/disease: Psychological Stress treatment Intervention:Pharmacopuncture
- Trial name
- NCT06107777
- Testing
- Pharmacopuncture, Korean medical treatment
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Jaseng Medical Foundation
Melanoma Stage Iv
Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study)
This is a phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with asymptomatic, untreated melanoma brain…
- Trial name
- ABC-X (NCT03340129)
- Testing
- Ipilimumab, Nivolumab, Stereotactic Radiotherapy
- Where
- 9 sites in Australia, Norway
- Volunteers
- 218 people
- Sponsor
- Melanoma Institute Australia
Hydatidiform Moles
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles
The researchers' laboratory is studying a rare class of highly recurrent hydatidiform moles. These are usually complete hydatidiform moles (CHM), but sometimes they are partial hydatidiform moles PHM).
- Trial name
- NCT01008501
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
COVID-19, SARS-CoV-2 Acute Respiratory Disease
Safety, Tolerability and Immunogenicity of Gam-COVID-Vac Vaccine in a Nasal Spray
Randomized, double-blind, placebo-controlled trial to evaluate safety and immunogenicity of intranasal "Gam-COVID-Vak" combined vector vaccine for the prevention of coronavirus infection caused by the SARS-CoV-2 virus.
- Trial name
- SPRAY (NCT05248373)
- Testing
- Gam-COVID-Vac
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
All-cause Mortality
ADL and CONUT for Predicting 1-year Mortality Risk in Older Adults After Hip Fracture
Hip fracture has a serious impact on the quality of life and even the survival of older adults. The multidisciplinary management of hip fracture has been shown to be effective in improving patient outcome and cost-effective in…
- Trial name
- NCT05814172
- Testing
- no intervention
- Where
- China
- Volunteers
- 303 people
- Sponsor
- Beijing Tongren Hospital
Peripheral Arterial Disease
The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention
Investigators hypothesize that high-dose n-3 polyunsaturated fatty acids (PUFA) oral supplementation will improve will improve systemic inflammation and patency of peripheral vascular intervention (PVI).
- Trial name
- OMEGA-PVI (NCT02096757)
- Testing
- Pro-Omega
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Chemotherapy-induced Nausea and Vomiting
Dexamethasone-sparing Approach Including NEPA Against Emesis Caused by Cisplatin
This study evaluates the possibility to reduce the total dose of dexamethasone, when administered with NEPA, to prevent chemotherapy-induced nausea and vomiting (CINV) in Non-Small Cell Lung Cancer (NSCLC) patients receiving a…
- Trial name
- LUNG-NEPA (NCT04201769)
- Testing
- Netupitant/Palonosetron, Dexamethasone
- Where
- 26 sites in Italy
- Volunteers
- 261 people
- Sponsor
- Consorzio Oncotech
Cervical Radiculitis, Pain
CESI With Low Dose Lidocaine and Transient Weakness
Cervical radicular pain is relatively common, often treated with epidural steroid injection (ESI), when conservative treatments like oral analgesics, physical therapy and activity modification have failed.
- Trial name
- NCT03127137
- Testing
- Experimental Group 1 triamcinolone and lidocaine, Experimental Group 2 triamcinolone and saline
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Northwestern University
Genetic Predisposition
Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols
Background: The purpose of this study is to identify changes in genes that cause human diseases. We would like to obtain some of you or your child s DNA and test for changes in genes that may contribute to a disease in you or…
- Trial name
- NCT01375543
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pelvic Pain
Lidocaine Injection and Ischemic Compression on Chronic Pelvic Pain Treatment
Our hypothesis is that with comparison of effectiveness of two most common techniques of treatment for myofascial pain syndrome (injection of local anesthesia and ischemic compression) we could choice the most adequate to treat…
- Trial name
- NCT00628355
- Testing
- lidocaine, Ischemic compression
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Endometriosis
Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Endometriosis is a chronic, inflammatory disease where endometrium-like tissue is present outside the uterus. Nerve cells in the proximity of this tissue express cytokine receptors causing a signaling cascade.
- Trial name
- NCT05558540
- Testing
- spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Prof. Velja Mijatovic
Burns, Electric Burns
Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns
Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue.
- Trial name
- NCT00812513
- Testing
- R-Pdf/Gbb 0.01% gel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- American Scitech International
Antiphospholipid Syndrome
Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies.
This study is being done to see if there are any long term health related issues in women with APA and recurrent miscarriages.
- Trial name
- NCT00180817
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Imperial College London
Cutaneous Leishmaniasis, American
Topical Sm29 in Combination With Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis.
This project is composed of a phase I study with the purpose of evaluating adverse reactions and the best dose to be used of Sm29 and a phase II randomized controlled study with 3 arms with the purpose of comparing the efficacy…
- Trial name
- NCT06000514
- Testing
- Sm29 Protein, Schistosoma Mansoni, Pentavalent antimony (Sbv)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Universitário Professor Edgard Santos
MRSA Infection, Bacteremia
Vancomycin Versus Ceftaroline in Patients With Infections Caused by MRSA That Are Susceptible to Ceftaroline
To compare the time to pathogen eradication, and the relationship to the time to clinical improvement, between ceftaroline and case-matched vancomycin treated controls in the treatment of adults with serious infections caused by…
- Conditions
- MRSA Infection, Bacteremia, ABSSSI, Pneumonia
- Trial name
- NCT01724671
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- CPL Associates
Out-of-Hospital Cardiac Arrest
EMERGEncy Versus Delayed Coronary Angiogram in Survivors of Out-of-hospital Cardiac Arrest
Sudden cardiac death (SCD) remains a major public health issue with a low survival rate. The most common cause of SCD is acute coronary artery occlusion.
- Trial name
- EMERGE (NCT02876458)
- Testing
- Immediate coronary angiogram, Delayed coronary angiogram
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Soft Tissue
Three-dimensional Assessment of Facial Alterations Induced by Dental Prostheses
Validation of the use of a facial scanner for assessment of modifications caused by the use of dental prostheses and determination of discrepancies related to conventional measurements with digital caliper.
- Trial name
- NCT04050878
- Testing
- Facial scanner (Bellus3D) to assess perioral alterations
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Secondary Hyperparathyroidism Due to Renal Causes, Vitamin D Insufficiency
Repeated-dose Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of CTAP101, Immediate-release Calcifediol, High-dose Cholecalciferol, and Paricalcitol Plus Low-dose Cholecalciferol in Patients With Secondary Hyperparathyroidism, Chronic Kidney Disease 3-4 and Vitamin D Insufficiency
An Open-Label, Repeated-Dose Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of Oral CTAP101 Capsules, Immediate- Release (IR) Calcifediol, High-Dose Cholecalciferol, and Paricalcitol Plus Low-Dose Cholecalciferol in…
- Conditions
- Secondary Hyperparathyroidism Due to Renal Causes, Vitamin D Insufficiency, CKD Stage 3, CKD Stage 4
- Trial name
- NCT03588884
- Testing
- Calcifediol Oral Capsule, Calcifediol Oral Product, Cholecalciferol
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- OPKO Health, Inc.
Ascites
Evaluation of Different Etiologies of Obscure Ascites
Ascites refers to fluid that accumulates within the peritoneal cavity. Although ascites is most commonly observed in patients with cirrhosis and resulting portal hypertension (approximately 85% of cases), 7% to 10% of patients…
- Trial name
- NCT03205748
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
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