Clinical trials: Etomidate
Interaction Drug Food
Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride
Sixty-eight healthy subjects were divided into three sequences: A, B and C. The effects of CYP2C19 inhibitor fluconazole and inducer rifampicin on ET-26-HCl injection were evaluated, and the effects of ET-26-HCl injection on…
- Trial name
- NCT06822166
- Testing
- rifampicin, Fluconazole, Omeprazole
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
QT Interval, Variation in
Clinical Trial of the Effect of Methoxyethyl Etomidate Hydrochloride on the QT Interval of the Heart
A single intravenous injection of 0.8mg/kg or 2.8mg/kg Et-26-hcl was given to 18 subjects. The effect of plasma concentration on QT interval was evaluated by C-QTc effect model, and the pharmacokinetic characteristics and safety…
- Trial name
- NCT06822153
- Testing
- ET-26 0.8mg/kg(low-dose) group, ET-26 2.8mg/kg(high dose) group
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Etomidate Induced Dose, Hysteroscopic Surgery
Etomidate Induction in Hysteroscopic Surgery
This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg.
- Trial name
- NCT05520645
- Testing
- etomidate, propofol
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anesthesia
Duration and Depth of Anesthesia Induced by a Bolus of Etomidate
Induction of general anesthesia requires to be safe and to ensure a proper level of anesthesia. A proper anesthesia is sufficient to guarantee loss of consciousness and amnesia and without being too depth leading to a…
- Trial name
- NCT05862753
- Testing
- induction by Etomidate bolus
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Etomidate, Myoclonus
Median Effective Dose of Remifentanil for the Prevention of Myoclonus Induced by Etomidate Injection
Since its introduction in 1973, etomidate has been widely used in clinical anaesthesia, especially in haemodynamically unstable patients, as a new anaesthetic induction drug with the advantage of low circulatory and respiratory…
- Trial name
- NCT05754762
- Testing
- Remifentanil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Etomidate, Hypotension
The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol in total intravenous anesthesia during abdominal surgery.
- Trial name
- NCT05810363
- Testing
- Etomidate - propofol mixture, Propofol
- Where
- China
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Ailin Luo
Congenital Hydronephrosis, Congenital Choledochal Cyst
Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention.
- Conditions
- Congenital Hydronephrosis, Congenital Choledochal Cyst, Fracture
- Trial name
- NCT02013986
- Testing
- etomidate, midazolam, propofol
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Du yi
Anesthesia
The Effect of Propofol or Etomidate on Cognitive Function for 1-3 Years Old Children
Based on China's guangxi guilin for a hernia operation in 1 to 3 years old preschool children propofol and etomidate on behavioral and cognitive function after intravenous anesthesia in according to beta protein in serum and…
- Trial name
- NCT02199990
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Guilin Medical University, China
Myoclonic Jerk
Effect of Pretreatment of Lignocaine Versus Midazolam in Prevention of Etomidate Induced Myoclonus.
This study is a randomized control trial and it was conducted to compare the effectiveness of pretreatment with lignocaine versus midazolam on the frequency of myoclonus associated with etomidate induction.
- Trial name
- NCT04921046
- Testing
- lignocaine, Midazolam 1 milligram Prefilled Syringe
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Etomidate Combined With Propofol, Hypertension
Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol for total intravenous anesthesia in elderly patients undergoing abdominal surgery.
- Trial name
- NCT07019246
- Testing
- EP mixture, Propofol
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Hepatic Insufficiency
Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
A Phase I clinical study to compare the pharmacokinetics, pharmacokinetics, and safety of intravenous administration of methoxyetomidate hydrochloride for injection in subjects with mild hepatic insufficiency (Child-pugh A)…
- Trial name
- NCT06176716
- Testing
- ET-26
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Etomidate Overdose of Undetermined Intent
A Dose-response Study of Lidocaine and Etomidate
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
- Trial name
- NCT01916642
- Testing
- Lidocaine 1mg/kg, Lidocaine 1.5mg/kg, Lidocaine 2mg/kg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Renal Insufficiency
Phase 1 Renal Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
Twenty-four subjects were divided into three groups: subjects with mild renal insufficiency, subjects with moderate renal insufficiency and subjects with normal renal function, with 8 subjects in each group.Subjects with mild…
- Trial name
- NCT06747520
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Healthy Elderly Subjects
Safety and Pharmacokinetics/ Pharmacodynamics of Methoxyethyl Etomidate Hydrochloride in Healthy Elderly Subjects
16 subjects were divided into two groups: One group consisted of healthy non-elderly subjects aged 18-64 years (including boundary value).
- Trial name
- NCT06764147
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Pharmacokinetics
Substance Balance Trial of Methoxyethyl Etomidate Hydrochloride
This study was a single-center, single-dose, open-label design with 6-8 healthy adult male subjects to evaluate the body material balance of [14C]ET-26.
- Trial name
- NCT06822114
- Testing
- Methoxyethyl Etomidate Hydrochloride
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Surgery
Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
Comparison of Etomidate plus Propofol vs. Propofol or Etomidate alone during induction of anesthesia.
- Trial name
- NCT03820388
- Testing
- Propofol 2mg/kg, Etomidate 0.3 mg/kg, Propofol 1 mg/kg
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Conscious Sedation Failure During Procedure
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions
There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials.
- Trial name
- NCT00596050
- Testing
- ketamine and midazolam, etomidate, fentanyl, and lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
General Anesthetic, Sedation
A Study Evaluating Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 and Etomidate for Induction of Anesthesia in Healthy Male Subjects
This study is designed as an open label, single dose combination of HSK3486 and etomidate in healthy adult male subjects. The study will evaluate the anesthetic/sedation effect of the combination of the 2 drugs and the safety…
- Trial name
- NCT04054063
- Testing
- HSK3486+ etomidate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Postpartum Hemorrhage
Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
Poor uterine tone after the birth of a baby may cause serious bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide. In the developed world the cesarean section rate is increasing.
- Trial name
- NCT03852797
- Testing
- Oxytocin, Ketamine, Propofol
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Neuromuscular Monitoring
Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.
- Trial name
- NCT02711917
- Testing
- MAC 0.5, MAC 0.75, MAC 1.0
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital