Clinical trials: Executive Function Disorders
Dementia, Memory Loss
Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild…
- Conditions
- Dementia, Memory Loss, Alzheimer Disease, Executive Dysfunction
- Trial name
- ACDCStim (NCT05661084)
- Testing
- Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Hebrew SeniorLife
Parkinson Disease
Impact of Exercise in Parkinson's Disease
The goal of this research is to identify an intervention that will improve cognition and sleep in persons with PD.
- Trial name
- NCT03495193
- Testing
- Exercise training, Sleep hygiene
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Preschool Child, Executive Function (Cognition)
Do Motor Synchrony Games Improve Self Regulation?
The goal of this study is to determine if progressively more challenging playground games (motor synchrony games) improve executive function in preschool-aged children.
- Trial name
- MSG (NCT06647693)
- Testing
- Motor Synchrony Games (MSG)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Down Syndrome
A Comparison of Cognitive-Motor Dual-Task Exercise and Exergaming on Balance, Functional Mobility, and Executive Function in Down Syndrome Children
Down syndrome (DS) is a genetic condition that compromises physical and cognitive function. Motor development delays define DS. Additionally, there are executive function issues.
- Trial name
- NCT06146907
- Testing
- cognitive motor dual task exercises, exergaming
- Where
- Saudi Arabia
- Volunteers
- 23 people
- Sponsor
- safia Darweesh halwsh
Major Depressive Disorder, Alcohol Use Disorder
Cognitive Dysfunction in the Addictions Study - Project 4 (P4)
The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD).
- Trial name
- CDiA-P4 (NCT06299787)
- Testing
- intermittent theta burst stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Traumatic Brain Injury
To Compare the Effect of Receiving the Technology-based Training Along With the Conventional Therapy to the Conventional Therapy Alone on Executive Functions Among People With Traumatic Brain Injury With Mild to Moderate Cognitive Deficit
The goal of this clinical trial is to compare the effect of receiving the technology-based training along with the conventional therapy to the conventional therapy alone on executive functions among people with traumatic brain…
- Trial name
- NCT06080269
- Testing
- technology based intervention along with conventional therapy, conventional therapy alone
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Alcohol-Induced Disorders, Nervous System, Alcohol Dependence
Health Mobile Cognitive Stimulation in Alcohol Use Disorder
The consequences of alcohol dependence are severe and may range from physical diseases to neuropsychological deficits in several cognitive domains.
- Trial name
- NCT01942954
- Testing
- Mobile health cognitive stimulation
- Where
- Portugal
- Volunteers
- 54 people
- Sponsor
- Pedro Gamito
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity
The Effects of Interrupting Prolonged Sitting With Bouts of Physical Activity on Neurocognitive Function in Obesity
It is projected that by 2030 almost 50% of adults in the USA will have obesity. High sedentariness and physical inactivity contribute to the obesity pandemic. Neurocognitive deficits compound the global burden of obesity.
- Trial name
- SITLess (NCT04926207)
- Testing
- Physical Activity Breaks Intervention, Talking Breaks Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Virtual Reality, Coordination Impairment
Effects of Immersive Virtual Reality Traning on an Eye-hand Coordination and Time Reaction
Virtual reality (VR) is a three-dimensional image, which is created by means of computer programs. In most educational communities VR has been used as an opportunity to support many students.
- Trial name
- NCT04662983
- Testing
- VR-training
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Multiple Sclerosis
Combined Effects of Balance and Cognitive Training in Patients With Multiple Sclerosis
Multiple sclerosis is a potentially disabling disease of the brain and spinal cord involving the central nervous system. Multiple Sclerosis can cause balance and cognitive impairment in patients, affecting overall quality of…
- Trial name
- NCT06845722
- Testing
- Balance training, Cognitive Rehabilitation:
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Alzheimer's Disease
Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition
Alzheimer's disease (AD) is an irreversible, progressive brain disease. It is the most common form of dementia and the major cause of functional dependence in the elderly.
- Trial name
- VIAGECO (NCT02520232)
- Testing
- Combination of aerobic and strength exercises, Stretching and balance exercise program
- Where
- 2 sites in France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Mild Cognitive Impairment, Alzheimer's Disease(AD)
Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and Prodromal Alzheimer's Disease
This study is a multicenter, randomized, double-blind, parallel-group, prospective confirmatory clinical trial designed to evaluate whether the Neuclare medical device can temporarily improve executive function (planning and…
- Trial name
- NCT07239310
- Testing
- Participants receive Neuclare Device while continuing their cognitive medication
- Where
- 7 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Deepsonbio
Stroke, Attention Disorder
Virtual-reality Exercises for Alleviating Attention Deficits in Patients With Acquired Brain Injury
Stroke is the leading cause of long-term disability with an increasing incidence, especially in young adults. Among the cognitive difficulties following brain damage, deficits in attention are frequent and pervasive, affecting…
- Trial name
- NCT05728840
- Testing
- Immersive virtual reality gamified cognitive activities, Double neuropsychological standard activities
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- Mindmaze SA
ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder
Virtual Reality-assisted Cognitive Rehabilitation in Autistic Youth With ADHD
This study aims to evaluate the effectiveness of a virtual reality-based intervention using the Virtual Reality Rehabilitation System (VRRS) to improve executive functions in autistic and ADHD youth aged 8 to 18 years.
- Trial name
- NCT07426302
- Testing
- VRRS Cognitive Training, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
TBI, Cognitive Dysfunction
Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond
For many Veterans, success in achieving goals at work, school and in other aspects of life are top priorities. The abilities to regulate attention, remember key information, and stay calm and on track are fundamental to this…
- Trial name
- NCT04109027
- Testing
- BrainStrong-BSR, BrainStrong-OPT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Autistic Disorder
e-Unstuck:Interactive e-Learning Software for Parents to Support Executive Functioning and Behavior Regulation in Children With Autism Spectrum Disorder
The goal of this project is to develop and test e-Unstuck, an e-learning intervention that (1) provides advanced training to parents of children with Autism Spectrum Disorder without Intellectual Disability (ASDwoID) on how to…
- Trial name
- e-Unstuck (NCT02708069)
- Testing
- e-Unstuck, Unstuck and On Target
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- 3-C Institute for Social Development
Obesity, Weight Loss
Metabolic and Behavioural Effects of CONTRAVE as Potential Mechanisms of Weight Loss in Adults With Obesity
Obesity is a common chronic disease linked with increased risk for other illnesses and earlier death. Our team and others have shown that many bodily and psychological changes occur when individuals are on calorie-restricted…
- Conditions
- Obesity, Weight Loss, Weight Management, Dietary Intervention
- Trial name
- NCT06809166
- Testing
- Contrave, Diet Program
- Where
- 3 sites in Canada
- Volunteers
- 40 people
- Sponsor
- The Royal's Institute of Mental Health Research
Cognitive Change, Diet, Healthy
Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in…
- Conditions
- Cognitive Change, Diet, Healthy, Metabolic Syndrome, Protection Against
- Trial name
- NCT06605898
- Testing
- MIND Diet, Control Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign