Clinical trials: Executive Function Disorders
Autism Spectrum Disorder
Teaching Academic Success Skills to Students With Autism Spectrum Disorders in Clinical Setting
The goal of the study is to develop an academic EF intervention, Teaching Academic Skills to Kids (TASK), for high functioning (i.e., IQ score ≥80) middle-school youth with ASD and EF deficits.
- Trial name
- TASK-R21 (NCT03606343)
- Testing
- Teaching Academic Skills to Kids
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Cognitive Impairment, Chronic Kidney Diseases
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive…
- Trial name
- EXEC (NCT05655325)
- Testing
- Home-based walking exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Columbia University
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Autism, Autism Spectrum Disorder
Cerebellum and Autism: Regional Specialization for Social and Executive Functions
The goal of this study is to determine the impact of neuromodulation to the cerebellum on social and executive functions in neurotypical young adults and young adults with autism.
- Trial name
- NCT05396352
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American University
Executive Dysfunction, ASD
Effect of rTMS on the Abnormal Executive Function of ASD Children
In this study, the investigators will explore the effects of repetitive transcranial magnetic stimulation (rTMS) on executive function deficits in high function autism spectrum disorder.
- Trial name
- NCT04237870
- Testing
- Active cTBS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Developmental Language Disorder
Training Inner Speech in Children With Developmental Language Disorder
The complex and unclear relationship between language and executive function (EF) creates barriers to developing effective interventions for children with developmental language disorder (DLD) whose language difficulties often…
- Trial name
- NCT06880731
- Testing
- Modeling with Verbal Mediation, Modeling Only
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Adult ADHD
Recollect the Game: A Novel Treatment for Executive Functioning Deficits in Adults With ADHD
Adults who have attention deficit hyperactivity disorder (ADHD) suffer from significant occupational, academic and social problems, many of which are believed to be a result of problems with executive functioning.
- Trial name
- NCT03437993
- Testing
- Recollect, the game, Tetris
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Executive Function Deficits (EFD)
Unstuck-Early Childhood Effectiveness & Implementation Trial
The goal of this clinical trial is to learn if a new school-based, Tier 2 (selective) cognitive-behavioral intervention called Unstuck and On Target for Early Childhood (Unstuck-EC) can treat executive function deficits in young…
- Trial name
- NCT07832344
- Testing
- Unstuck and On Target for Early Childhood
- Volunteers
- 90 people
- Sponsor
- Children's National Research Institute
Schizophrenia, Schizophrenia Spectrum Disorder
tDCS and Executive Function Training for Schizophrenia
Schizophrenia-spectrum disorders are the most persistent, debilitating, and economically burdensome mental illnesses worldwide. Cognitive remediation (CR) is a psychological intervention based on principles of learning and…
- Conditions
- Schizophrenia, Schizophrenia Spectrum Disorder, Schizophrenia and Related Disorders
- Trial name
- NCT05389345
- Testing
- Transcranial direct current stimulation, Executive function training
- Where
- Canada
- Sponsor
- University of Toronto
Anomia, Post-stroke Aphasia
Executive Training and Anomia Therapy in Chronic Post-stroke Aphasia
Aphasia is a devastating acquired language impairment mainly caused by stroke, in which anomia is a quintessential clinical feature.
- Trial name
- ETAT PSA (NCT05101408)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Stroke
Efficacy of Music-Based Telerehabilitation After Stroke
The goal of this clinical trial is to learn if a music-based telerehabilitation intervention implemented at home works to treat different kinds of neurological deficits caused by stroke.
- Trial name
- NCT06804304
- Testing
- Music-based telerehabilitation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Teppo Sarkamo
Cognitive Impairment
Compensatory and Restorative Rehabilitation Techniques in Stroke
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
- Trial name
- NCT06325085
- Testing
- compensatory and restorative rehabilitation techniques, Traditional cognitive rehabilitation training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Leukemia, Down Syndrome
Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome
Survivors of acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits, reduced educational and psychosocial outcomes, and lower quality of life.
- Trial name
- NCT02859389
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- St. Jude Children's Research Hospital
Alzheimer Disease 2 Due to Apoe4 Isoform
Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD
This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.
- Trial name
- NCT05591313
- Testing
- LI-40, MI-30, HI-16
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Schizophrenia, Schizoaffective Disorder
Optimizing CBSST With Executive Function Training for Schizophrenia (R33)
This randomized controlled clinical trial will test a blended intervention that combines Executive Function Training with Cognitive-Behavioral Skills Training (E-CBSST).
- Trial name
- ECBSST R33 (NCT07658391)
- Testing
- E-CBSST, E-SC
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- University of California, San Diego
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Autism Spectrum Disorder
Executive Function Intervention for High School Students With ASD
The purpose of this project is to test the effectiveness of a novel school-based intervention targeting executive function skills, including flexibility and planning, in college-track, transition-age youth with ASD.
- Trial name
- NCT03199937
- Testing
- Flexible Futures, Current standard of care
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Children's National Research Institute
Cognitive Impairment, Mild
Telerehabilitation Cognitive Impairments Following Chemotherapy Feasibility Study
Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom and adaptable virtual reality simulations on a wearable device enhanced with biosensors.
- Trial name
- TCIFCF (NCT04972019)
- Testing
- Telerehabilitation Experimental Group
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Bright Cloud International Corp
ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder
Virtual Reality-assisted Cognitive Rehabilitation in Autistic Youth With ADHD
This study aims to evaluate the effectiveness of a virtual reality-based intervention using the Virtual Reality Rehabilitation System (VRRS) to improve executive functions in autistic and ADHD youth aged 8 to 18 years.
- Trial name
- NCT07426302
- Testing
- VRRS Cognitive Training, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Attention Deficit Hyperactivity Disorder
Executive Function/Metacognitive Training for At-Risk Preschoolers
The purpose of this study is to see if an intervention training executive functions like attention, working memory, and self-regulation for preschoolers at risk for Attention-Deficit/Hyperactivity Disorder is feasible, acceptable…
- Trial name
- ETAM (NCT01675869)
- Testing
- Executive Training of Attention and Metacognition (ETAM), Attention Control
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati