Clinical trials: Executive Function Disorders
Parkinson Disease
Deep Brain Stimulation on Dual-task Gait Performance in PD
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Motor symptoms include rigidity, bradykinesia, tremor, and postural instability, these motor symptoms can cause gait…
- Trial name
- NCT05314322
- Testing
- Deep brain stimulation with high frequency, Deep brain stimulation with low frequency
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Yang Ming Chiao Tung University
Cognitive Change, Diet, Healthy
Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in…
- Conditions
- Cognitive Change, Diet, Healthy, Metabolic Syndrome, Protection Against
- Trial name
- NCT06605898
- Testing
- MIND Diet, Control Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Suicidal Ideation
Improving Caregivers' Ability to Manage Life Stress
The COVID-19 pandemic has led to increased caregiving demands for caregivers of Veterans with dementia. Dementia caregivers are particularly at-risk for depression and anxiety, known risk factors for increased suicidality.
- Trial name
- NCT05539352
- Testing
- Problem Solving Therapy (PST) plus EUC
- Where
- United States
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL
Aerobic exercise is a promising treatment modality for cognition in persons with TBI, but effects are consistently small. This study aims to investigate the effect of difference environments during moderate intensity cycling…
- Trial name
- VITAL (NCT04901286)
- Testing
- Exercise Only, Exercise + Non-Immersive Virtual Reality, Exercise + Immersive Virtual Reality
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Mild Cognitive Impairment (MCI)
Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults.
- Trial name
- NCT07097051
- Testing
- real tACS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- High Point University
Traumatic Brain Injury, TBI
Exploring Relationships Among Balance Performance, Cognitive Dysfunction, Affective Dysregulation, and Community Integration in Veterans With Traumatic Brain Injury (TBI)
The overarching goal of the proposed study, named SYNERGY, is to explore relationships among balance performance, cognitive function, affective dysregulation, as they relate to the community re-integration in Veterans with TBI.
- Trial name
- NCT02366442
- Testing
- Exploring relationships among balance performance, cognitive dysfunction, affective dysregulation, and community integration in Veterans with Traumatic Brain Injury (TBI).
- Volunteers
- 80 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Autism Spectrum Disorder, Executive Dysfunction
Non-invasive Brain Stimulation in Children With Autism
Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who…
- Conditions
- Autism Spectrum Disorder, Executive Dysfunction, Child Autism
- Trial name
- NCT05105126
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Spinal Cord Injury
Body Temperature in Persons With Tetraplegia When Exposed to Heat
The deleterious effects of hyperthermia are well appreciated in able-bodied persons. However, the consequences of impaired regulation of normal body temperature on cognitive performance of persons with tetraplegia is not known.
- Trial name
- NCT01890915
- Testing
- Heat Exposure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Obstructive Sleep Apnea (OSA)
The Effects of Hypoxic Burden on Executive Function (EF) in Preschool Children With Obstructive Sleep Apnea
The goal of this observational study is to study the effect of hypoxic burden on executive function in preschool children aged 2-6 years who have OSA.
- Trial name
- NCT07023458
- Testing
- Brief-P
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Mahidol University
Late-life Depression, Treatment-resistant Depression
SSM vs HEP in Late-Life Depression
The investigators will conduct a randomized controlled trial (RCT), comparing SSM (n=96) versus HEP (n=96) in 192 LLD participants stratified by site and presence of treatment resistant late life depression (TR-LLD).
- Trial name
- NCT03564041
- Testing
- Sahaj Samadhi Meditation (SSM), Health Enhancement Program (HEP)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer's Disease, Mild Cognitive Impairment
Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
This study compares different music therapy (MT) experiences and their impact on memory and language in patients with Alzheimer's disease and Mild Cognitive Impairment.
- Trial name
- NCT04666077
- Testing
- Home-based MT through Supervised, Supported Singing (H3S), Individualized Music Therapy (IMT), Attention Control (AtCon)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Falls, Fall Risk
The Relationship Between Self-Awareness and Risk of Falls During Walking in Adults
This study examines the relationship between self-awareness and the risk of falls during walking in older adults and rehabilitation patients. Falls are a major health concern among older adults worldwide.
- Conditions
- Falls, Fall Risk, Fall Risk Factors, Cognitive Dysfunction
- Trial name
- SAFR (NCT07367763)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Insomnia
Psychological Intervention on Cold Executive Function and Academic Performance in University Women With Insomnia
Sleep disturbances, particularly insomnia, are highly prevalent among university women and are associated with impairments in executive functioning and academic performance.
- Trial name
- LUNA MUJER (NCT07529652)
- Testing
- Psychological Program to Improve Sleep Quality
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Universidad Autonoma de Baja California
Parkinson Disease
Impact of Exercise in Parkinson's Disease
The goal of this research is to identify an intervention that will improve cognition and sleep in persons with PD.
- Trial name
- NCT03495193
- Testing
- Exercise training, Sleep hygiene
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Stroke
Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
About two-third individuals with acquired brain injury (ABI) experience cognitive impairments. Deficits in executive functions is one of the most prevalent cognitive impairments following ABI which result in decline of recovery…
- Conditions
- Cognitive Impairment, Stroke, Acquired Brain Injury
- Trial name
- NCT04033952
- Testing
- Strategy Training
- Where
- 3 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Medical University
Autism Spectrum Disorder
Videogame-based Tool for Job Search and Executive Function Improvement in Adults With ASD
This study aims to assess the efficacy of Identifor, a strength- based, person-centered, vocational assessment tool to develop a more effective way to identify individual abilities, skills, and interests.
- Trial name
- NCT05066906
- Testing
- Use of Identifor assessment tool and Companion app, Referral to employment agencies
- Sponsor
- Stanford University
Parkinson´s Disease
Gait Training With Executive Functions Tasks in Subjects With Parkinson´s Disease: A Study Protocol
The aim of this study is the development and implementation of a new protocol of a physical therapy training, based on a gait training associated with executive tasks, for treatment of individuals with Parkinson's Disease.
- Trial name
- NCT01650610
- Testing
- Gait training executive functions tasks
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognitive Change, Metabolic Syndrome, Protection Against
Nutritional Intervention for Sustaining Health (NURISH) Trial
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in…
- Conditions
- Cognitive Change, Metabolic Syndrome, Protection Against, Diet, Healthy
- Trial name
- NCT06437860
- Testing
- MIND Diet, Control Diet
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcohol Use, Underage, Alcohol Problem Drinking
Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change
This study will be the first to explore mindfulness as a prevention intervention among transition age youth and those with previous involvement in the juvenile or criminal justice system with substance use problems and history of…
- Conditions
- Alcohol Use, Underage, Alcohol Problem Drinking, Substance Use
- Trial name
- NCT04160754
- Testing
- Mindfulness Based Relapse Prevention, Control (CTL)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Southern California