Clinical trials: Exhaled Breath Condensate
Attitude to Health
Mucociliary Clearance, Airway Inflammation and Nasal Symptoms in Urban Motorcycle-drivers
Professionals working in polluted areas may present increased airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis.
- Trial name
- NCT03510585
- Testing
- saline and sniffing, sniffing
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Carboxyhemoglobin, Vital Signs
Evaluation of the Acute Effect of Water-Pipe Smoking on the Respiratory System
Title: The acute effect of water pipe smoking on exhaled nitric oxide (eNO) and exhaled breath condensate (EBC) pulmonary function tests in healthy volunteers Objectives: To evaluate the acute effect of one cession of water pipe…
- Conditions
- Carboxyhemoglobin, Vital Signs, Fractional Exhaled NO, Exhaled Breath Condensate
- Trial name
- NCT01157832
- Where
- 2 sites in Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Obstructive Sleep Apnea, Inflammation
A Community Study of the Risk for Obstructive Sleep Apnea and Respiratory Inflammation in an Adult Chinese Population
We aimed to investigate the relationship between obstructive sleep apnea (OSA) risk and respiratory inflammation evaluated by the exhaled breath condensate （EBC）interleukin-6 IL-6 and plasma SP-D, based on the Berlin…
- Conditions
- Obstructive Sleep Apnea, Inflammation, Exhaled Breath Condensate, Surveys and Questionnaires
- Trial name
- NCT04832711
- Where
- China
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Inadequate or Impaired Respiratory Function
The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers
Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of…
- Trial name
- Nanoexposure (NCT01599845)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy
A Pilot Feasibility Study of Detection of IL-11 and Other Cytokines in the Exhaled Breath Condensate (EBC) and Blood of Healthy Volunteers
IL-11 is a receptor previously proven to be highly expressed in human lungs with idiopathic lung fibrosis, and in animal model, IL-11 receptor neutralizing antibody has been shown to prevent the process of fibrosis in…
- Trial name
- NCT05536375
- Testing
- Exhaled breath condensate collection and blood draw
- Where
- Singapore
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Asthma
Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma
This study is a longitudinal single-center pilot study designed to describe changes in lung function and levels of noninvasive biomarkers of airway inflammation in children ages 6-18 years over two months following…
- Trial name
- NCT01227070
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Lung Cancer
Diagnosis of Lung Cancer From Exhaled Breath With Silicon Biophotonic Device
The overall objective of this proposal is to develop a non-invasive, inexpensive and accurate device that detects VOCs in exhaled breath for lung cancer screening.
- Trial name
- NCT01660087
- Testing
- Biophotonic platform for VOC detection
- Where
- 2 sites in Singapore
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Asthma, COPD Exacerbation
Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease
A cross-sectional, observational study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity and symptom control in patients with Asthma and COPD and volunteers with no history…
- Trial name
- EXHALE 1A (NCT04061291)
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Cystic Fibrosis, Healthy
Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis
Our aims were to determine if exhaled breath condensate (EBC) could detect differences in ion regulation between cystic fibrosis (CF) and healthy and measure the effect of the albuterol on EBC ions in these populations.
- Trial name
- NCT01880723
- Testing
- Albuterol
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Asthma, Vitamin D Resistant Rickets
Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
- Trial name
- NCT01578824
- Testing
- Methacholine Challenge Test
- Where
- Israel
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Asthma
Biomarkers of Irritant-Induced and Allergic Asthma
Asthma is a heterogeneous disease, and although much is understood about mechanisms of inflammation in allergic asthma, less is known about mechanisms of irritant-induced asthma (IA).
- Trial name
- NCT02740543
- Testing
- Fluticasone propionate HFA 220
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Aspergillosis Pneumonia, Pneumocystis Pneumonia
Non-invasive Diagnosis of Invasive Pulmonary Aspergillosis by Use of Biomarkers in Exhaled Breath Condensate
In this study, a new, non-invasive method for diagnosis of pulmonary aspergillosis (PA) will be tested in a clinical pilot project.
- Trial name
- NIPA (NCT04358419)
- Testing
- Aspergillus specific proteins in exhaled breath condensate (EBC), Pneumocystis jirovecii DNA in exhaled breath condensate (EBC)
- Where
- Denmark
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Inger Lise Gade
Air Pollution Exposure, Oxidative Stress
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress
This pilot clinical trial will evaluate the feasibility and potential health effects of a nutrition-based intervention among adults living in communities affected by air pollution near the Port of Savannah, Georgia.
- Conditions
- Air Pollution Exposure, Oxidative Stress, Airway Inflammation
- Trial name
- NCT07797413
- Testing
- Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
COPD Exacerbation
A Cross Sectional, Diagnostic Accuracy Study to Validate the Use of a New Device(Inflammacheck™) in Diagnosing COPD
A cross-sectional, diagnostic accuracy study to evaluate the use of the 'Inflammacheck™' device in the diagnosis of COPD. Participants will be asked to provide an exhaled breath sample for measurement of their EBC H2O2 using…
- Trial name
- EXHALE 1V (NCT04024657)
- Where
- United Kingdom
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Lung Cancer
Serum and Exhaled Breath Condensate MALDI-MS of Lung Cancer. (SPORE)
RATIONALE: Collecting and storing samples of blood and exhaled breath from patients with cancer and from healthy participants to study in the laboratory may help doctors learn more about changes that occur in DNA and identify…
- Trial name
- NCT00898209
- Testing
- protein expression analysis, proteomic profiling, biologic sample preservation procedure
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pulse Spectrum Analysis, Pulmonary Function
Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath Condensate
Our hypothesis is that radial arterial pulse may reflect the severity and airway function in asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery in adult asthmatics, and evaluate its…
- Conditions
- Pulse Spectrum Analysis, Pulmonary Function, FeNO, Metabolites
- Trial name
- NCT01719393
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma, Cystic Fibrosis
Standardisation of Measurements in Exhaled Breath and Exhaled Breath Condensate.
Background: in various pediatric pulmonary diseases such as asthma, cystic fibrosis or bronchopulmonary dysplasia an increased inflammation is present.
- Conditions
- Asthma, Cystic Fibrosis, Chronic Lung Disease, Pneumonia
- Trial name
- NCT00983671
- Where
- Netherlands
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bronchiectasis
Exhaled Breath Condensate Assessment in Stable Non-Cystic Fibrotic Bronchiectasis
The measurement of markers in the expired breath condensate has proven to be a useful method for assessing and monitoring airway inflammation.
- Trial name
- NCT03643263
- Where
- China
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China