Clinical trials: Exposure
HIV/AIDS PREVENTION
Increasing PrEP Among African Americans in Louisville KY
This study evaluates the effectiveness of a multifaceted strategy to increase pre-exposure prophylaxis (PrEP; a medication regimen to reduce HIV risk) uptake among high risk African Americans in Louisville, KY.
- Trial name
- NCT03559595
- Testing
- Project Prevent
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Atrial Fibrillation, Venous Thromboembolism
A Study on the Impact of Rabeprazole-induced Elevated Stomach pH on APO-Dabigatran Exposure in Healthy Volunteers
Open-label, crossover study recruiting 46 healthy male volunteers comparing the absorption of APO-dabigatran 150 mg per oral (PO) in the absence or presence of a proton pump inhibitor.
- Trial name
- TADA (NCT04157881)
- Testing
- RABEprazole 20 Mg Oral Delayed Release Tablet, APO-Dabigatran 150mg
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Disorders of Environmental Origin
Reducing Pesticide Exposure in Minority Families
This is a community-based participatory research program focusing on pesticide contamination in migrant farmworker families.
- Trial name
- NCT00014807
- Testing
- Reducing Pesticide Exposure in Minority Families
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Help-Seeking Behavior, Pre-exposure Prophylaxis Use
Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)
The goal of this quasi-experimental, community intervention is to reduce HIV sexual risk among Latino immigrant bisexual men or men who have sex with men.
- Conditions
- Help-Seeking Behavior, Pre-exposure Prophylaxis Use, Condomless Sex, Risky Health Behavior
- Trial name
- NCT07475702
- Testing
- Moon and Sun Brothers: A Community Prevention Intervention
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- San Francisco State University
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Pregnancy Related, Tobacco Smoking
Effects of Prenatal Tobacco Smoke Exposure on Lung Function and Respiratory Epithelium Functionality in Newborns
Despite public campaigns to prevent cigarette smoking, it's about 20% of women who keep on smoking during pregnancy, exposing their fetus to prenatal tobacco adverse effects.
- Conditions
- Pregnancy Related, Tobacco Smoking, Lung Smokers, Newborn
- Trial name
- NCT03047967
- Testing
- lung function tests, Nasal brushing
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Lipid Tear Deficiency (Disorder), Dry Eye Disease
Changes in Tear Lipid Layer Thickness After Short Exposure to Light Emitting Diode Displays
Video display terminals (VDTs) are ubiquitous, and engagement in digital screens has grown substantially across all age groups worldwide. Prolonged exposure to VDTs is associated with the development of various health problems.
- Trial name
- NCT05003128
- Testing
- LED screen (InnoLux, Taiwan)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Excessive Screen Exposure in Infancy, Parental Education and Infant Screen Use
EVALUATION of SCREEN TIME of BABIES
This study aims to evaluate whether educating mothers can reduce screen time in infants aged 6-18 months. Early exposure to screens has been associated with potential negative effects on child development, including language…
- Trial name
- NCT07513636
- Testing
- Parental Education Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Influenza
A Randomised Controlled Trial on the Effect of Post-exposure Oseltamivir Prophylaxis on Influenza Transmission in Nursing Homes
The incidence of severe morbidity and mortality following an influenza infection during the annual influenza epidemics is highest among the elderly population and 90% of influenzaassociated mortality occurs in this group.
- Trial name
- PEPpIE (NCT01053377)
- Testing
- Tamiflu (verum)
- Where
- Netherlands
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Institute for Public Health and the Environment (RIVM)
Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use
Maternal and Neonatal Outcomes Following Exposure to Benzodiazepines During Pregnancy
This is a nationwide cohort study to assess maternal and neonatal outcomes following exposure to benzodiazepines during pregnancy.
- Conditions
- Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use, Congenital Anomaly
- Trial name
- NCT04856436
- Testing
- Benzodiazepine
- Where
- South Korea
- Volunteers
- 3,094,227 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University
Hypertension
The Double Exposure Study: The Impact of Job Strain and Marital Cohesion on Blood Pressure
Psychosocial and lifestyle stressors, such as job strain (JS) and marital factors have previously been associated with a sustained increase in blood pressure (BP).
- Trial name
- NCT00133653
- Testing
- Observational
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
HIV, Adolescent Behavior
Gender-Specific Combination HIV Prevention for Youth in High Burden Settings (MP3-Youth)
MP3 Youth is a pilot study to evaluate the feasibility and acceptability of a gender-specific combination HIV prevention package for youth (aged 15-24) in high burden settings.
- Conditions
- HIV, Adolescent Behavior, Gender
- Trial name
- MP3-Youth (NCT01571128)
- Testing
- Male-Specific Intervention Package, Female-Specific Intervention Package, Pre-Exposure Prophylaxis (Females)
- Where
- 3 sites in United States, Kenya
- Volunteers
- 1,215 people, healthy volunteers welcome
- Sponsor
- New York University
Biomarker Feedback, Smoking Cessation
Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
1. To do formative work with healthcare providers, clinic staff and parents to develop a protocol for a clinic system to routinely collect blood from children at risk of SHS exposure conduct laboratory testing for tobacco…
- Conditions
- Biomarker Feedback, Smoking Cessation, Secondhand Smoke Exposure, Provider Behavior
- Trial name
- NCT01145729
- Testing
- Biomarker Feedback
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health (NIH)
Stress-exposed Urban Male Youth
Improving Wellness for Young Men
This study assesses the impact of a mindfulness-based stress reduction program compared with a health education program for urban middle-school male youth on outcomes of psychological symptoms, coping, stress, sleep, and behavior.
- Trial name
- NCT01650233
- Testing
- Mindfulness-based stress reduction
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Influenza
Evaluating Modes of Influenza Transmission Between Humans
Most countries of the world, including the USA are making preparations for a possible influenza pandemic. Such an event will constitute a global public health emergency, but it is impossible to predict when this will happen.
- Trial name
- NCT01150149
- Testing
- No face touch, Surgical face mask, Surgical face mask + no face touch
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
Cardiopulmonary Function, Environmental Exposures
Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health
The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health.
- Trial name
- NCT07005193
- Testing
- Cooking ventilation facilities, Using liquefied gas for cooking, Using solid fuels for cooking
- Where
- 3 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Smoking Behaviors
Acute Effects of Cigarette Packaging and Charcoal Filtration on Perceptions, Use Behaviors, and Harm Exposure
This single laboratory session pilot study will examine the acute effects of cigarette filter type and packaging on initial product perceptions, use, and exposure.
- Trial name
- SKY Pilot (NCT05157048)
- Testing
- Charcoal-filtered cigarette, Non-charcoal filtered cigarette
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Chronic Kidney Diseases, Microplastics
Biomonitoring of Internal Exposure to MNPLs, and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)
Micro and nanoplastics (MNPLs) effects on human heath is still preliminary. Chronic kidney disease (CKD) participants, specially does patients submitted to hemodialysis, are a population high exposed to plastics.
- Conditions
- Chronic Kidney Diseases, Microplastics, Nanoplastics, Genotoxic Damage
- Trial name
- NCT05155267
- Testing
- Biomonitoring study to detect MNPLs in biological samples and study of their health effects
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
Hypersensitivity, Dentin Sensitivity
Clinical Assessment of Bifluorid 10 vs Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient
Aim of the study will be conducted to compare the efficacy of bifluoride (NaF and CaF) versus conventional fluoride varnish (Sodium Flouride) in the management of hypersensitivity of exposed cervical area in adult patients over 2…
- Trial name
- NCT04485299
- Testing
- Bifluorid 10 ,VOCO, Sodium Fluoride 5% Dental Varnish
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Noise Exposure
Exposure to Intense and Prolonged Noises During Pregnancy
Hearing is an essential element for the development of language and conditions an appropriate cognitive, psychological and social development of children.
- Trial name
- GestaNoise (NCT05911204)
- Testing
- Questionnaire about intense noises exposure during pregnancy
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
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