Clinical trials: Exposure
Cardiometabolic Diseases
Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.
- Trial name
- DEBATE (NCT06426082)
- Testing
- Thermoneutral condition, Cold condition, Aerobic exercise condition
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Dermatitis
Infant Fecal Insult Study
The rationale for the study is to better understand the dynamics of skin microflora following skin barrier disruption in an adult dermatitis model.
- Trial name
- NCT02979210
- Testing
- Artificial Fecal Insult, Phosphate Buffered Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Postmenopause
Study Of Pharmacokinetic (PK) Profile of Bazedoxifene (BZA) in 2 BZA/Conjugated Estrogen Forms
The purpose of the study is to understand how bazedoxifene is absorbed in the body when it is given in combination with 2 different formulations of conjugated estrogens.
- Trial name
- NCT00479778
- Testing
- Bazedoxifene/conjugated estrogens
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Anxiety
Cognitive Processing Therapy in Syrian Women Exposed to IPV
This study aims to explore the efficacy of cognitive processing therapy (CPT) in treating depression, anxiety, PTSD, and difficulties with emotion regulation in Syrian females who have suffered intimate partner violence (IPV).
- Conditions
- Depression, Anxiety, PTSD
- Trial name
- NCT05674591
- Testing
- Cognitive Processing Therapy (CPT)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Innate Inflammatory Response, Vaccination
PFAS Exposure and Immune Response to Vaccination in Adults
This clinical trial aims to investigate how exposure to Perfluorononanoic acid (PFNA), a type of per- and polyfluoroalkyl substance (PFAS), affects the immune response to the standard tetanus and diphtheria (Td) vaccine.
- Conditions
- Innate Inflammatory Response, Vaccination, Diphtheria, Tetanus
- Trial name
- NCT06588530
- Testing
- TENIVAC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
HIV, Sexually Transmitted Diseases
Mobile-Based Application "MyChoices"
This study is testing the acceptability and feasibility of MyChoices, a mobile application (app), to promote HIV testing and pre-exposure prophylaxis (PrEP) uptake among young men who have sex with men (YMSM).
- Conditions
- HIV, Sexually Transmitted Diseases, Pre-exposure Prophylaxis, Risk Reduction
- Trial name
- NCT03179319
- Testing
- MyChoices
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Testicular Germ Cell Tumor
A Case-control Study to Assess the Association Between Environmental, Domestic and Occupational Exposures and the Risk of Testicular Germ Cell Tumor
The incidence of testicular germ cell tumors, the most common cancer in men aged 15 to 45 years, has doubled in France in 30 years.
- Trial name
- TESTIS (NCT02109926)
- Testing
- Phone interview and blood test
- Where
- 22 sites in France
- Volunteers
- 1,367 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Genetic Predisposition, Exposure, Environmental
Mayo Clinic Precure - Prospective Study
The goal of this observational study is to 1) better understand and predict biological processes before disease begins or is identified, 2) study genomic and environmental contributors to disease, 3) identify ways to stop disease…
- Trial name
- NCT07332598
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Contraception, Female Contraception
A Study to Evaluate the Exposure of Norelgestromin and Ethinyl Estradiol From Commercial Lots of EVRA (a Transdermal Contraceptive Patch Manufactured by LOHMANN Therapie-Systeme) and CILEST (an Oral Contraceptive)
The objective of this study is to estimate exposure to the hormones norelgestromin, norgestrel, and ethinyl estradiol in healthy female volunteers across multiple commercial lots of EVRA® (a transdermal contraceptive patch…
- Trial name
- NCT00258063
- Testing
- EVRA® transdermal contraceptive patch containing 6 mg of norelgestromin and 0.60 mg of ethinyl estradiol (versus CILEST® tablets).
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Disorders of Environmental Origin
Reducing Pesticide Exposure in Minority Families
This is a community-based participatory research program focusing on pesticide contamination in migrant farmworker families.
- Trial name
- NCT00014807
- Testing
- Reducing Pesticide Exposure in Minority Families
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Atherosclerosis
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature
Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e.
- Trial name
- DEVA (NCT04098536)
- Testing
- Diesel exhaust
- Where
- 2 sites in Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Athens
Physical Inactivity, Environmental Exposure
Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes
By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas.
- Conditions
- Physical Inactivity, Environmental Exposure, Mental Health Wellness 1
- Trial name
- NCT05865782
- Testing
- Schoolyard reconstruction
- Where
- Sweden
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Exposure to Medical Diagnostic Radiation
Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent
Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion.
- Trial name
- NCT01855204
- Testing
- Computed tomographic urography
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Malnutrition, Child, Arsenic Poisoning Chronic
Effect of Chronic Arsenic Exposure on Malnutrition of Under Five Children
Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z…
- Trial name
- NCT03893721
- Testing
- arsenic exposure
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Covid19, COVID-19 Prevention
Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19
COVID-19 affected more than 9 million of people with more than 130 thousand death in India. If adequate preventive and therapeutic measures are not taken, India has very high risk of affecting million of more people with high…
- Trial name
- PEP-CQ (NCT04858633)
- Testing
- Hydroxychloroquine (HCQ), Standard care
- Where
- India
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypoxia
Effect of Short-term Simulated Altitude Exposure on Cardiopulmonary Functional Capacity
To determine if exposure of older volunteers, age 50-70y, who are healthy, but not physically active, to 7 days of mild hypoxia (15% oxygen, equivalent 2440m) will improve cardiopulmonary functional capacity.
- Trial name
- NCT02523716
- Testing
- Hypoxia, Normoxia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Smoking
Tobacco Constituents and Biomarkers
This proposal addresses several research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products as mandated by the Family Smoking Prevention and Tobacco Control Act.
- Trial name
- NCT04090606
- Testing
- FTC Method Smoking Regimen, Massachusetts Method Smoking Regimen, Health Canada Intense Smoking Regimen
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Sexually Transmitted Infections (STIs), HIV
Development of a Predictive Model for Sexually Transmitted Infections in Individuals Using Pre-Exposure Prophylaxis for HIV in Spain
Objective: To develop and validate a predictive model for acquiring sexually transmitted infections (STIs) in individuals using HIV pre-exposure prophylaxis (PrEP) within the national program providing this strategy.
- Conditions
- Sexually Transmitted Infections (STIs), HIV, PrEP
- Trial name
- STI_PrEPare (NCT06860945)
- Testing
- No Intervention: Observational Cohort
- Where
- 26 sites in Spain
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Valme
Aging, Fall
Design and Implementation of a Physical Exercise Program With Virtual Reality to Improve Functional Capacities in Older People.
TITLE: Desing and implementation of a Immersive Virtual Reality exercise program to improve balance in older people INTRO: Older people grow around the world at a faster rate than any other age group, resulting in an accelerated…
- Conditions
- Aging, Fall, Quality of Life
- Trial name
- NCT04336670
- Testing
- Immersive Virtual Reality exercise program, Usual care
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pablo Campo-Prieto
Covid19
Community-based Post-exposure Prophylaxis for COVID-19
Specifically identified Ayurvedic preparations is recommended by ministry of AYUSH as post-exposure prophylaxis to efficaciously prevent a negative person who has come into contact with COVID-19-positive.
- Trial name
- NCT04920773
- Testing
- Guduchi Ghanvati, Standard guidelines
- Where
- 2 sites in India
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
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