Clinical trials: External Ventricular Drain
Traumatic Brain Injuries, Intracranial Hypertension
Security and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain Injury
This study aims to compare the effectiveness and safety of a standard intervention called ventriculostomy for managing increased intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI).
- Trial name
- SEALS-TBI (NCT06772155)
- Testing
- Ventriculostomy, Ventriculostomy + Locking Device
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Intracranial Pressure Increase
Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD)
The placement of external ventricular drainage (EVD) is a life-saving procedure used to relieve high pressures in the brain. Often performed at the bedside, a small tube (catheter) is inserted into one ventricle of the brain to…
- Trial name
- NCT05931991
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Intraventricular Hemorrhage, Lumbar Drainage
Lumbar Drainage of Intraventricular Hemorrhage
Intracerebral hemorrhage (ICH) is a debilitating and fatal disease, especially when the hemorrhage is also entering the cerebral ventricles leading to acute hydrocephalus.
- Conditions
- Intraventricular Hemorrhage, Lumbar Drainage, External Ventricular Drainage
- Trial name
- DRAIN IVH (NCT06510842)
- Testing
- External drainage of intraventricular hemorrhage
- Where
- 12 sites in Germany
- Volunteers
- 354 people
- Sponsor
- University Hospital Heidelberg
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage
The DRAIN trial is an international multi-centre, 1:1 randomised, parallel-group, superiority clinical trial investigating gradual weaning vs.
- Trial name
- DRAIN (NCT03948256)
- Testing
- Control intervention, Experimental intervention
- Where
- 4 sites in Denmark, Norway
- Volunteers
- 245 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Presence of High Intracranial Pressure
An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an External Ventricular Drainage (EVD) Device
Invasive intracranial pressure (ICP) monitoring is highly effective, but involves risks. HS-1000 measures ICP non-invasively by assessing the acoustic properties of the patient's head.
- Trial name
- NCT02284217
- Testing
- EVD
- Where
- 7 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- HeadSense Medical
Occlusion
Comparison of EVD Catheter Diameter on Occlusion and Replacement
A randomized trial comparing small versus large catheters in terms of occlusion and need for replacement to confirm differential occlusion risk based on catheter size.
- Trial name
- NCT03248739
- Testing
- Clear Bactiseal 'large' catheter (EVD), Orange Bactiseal 'small' catheter (EVD)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Pharmacokinetics
Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Ceftolozane/tazobactam is an emerging newly available antibiotic that has a broad spectrum of activity, and could be potentially useful in the management of central nervous system infections.
- Trial name
- NCT03309657
- Testing
- Ceftolozane/tazobactam
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Royal Brisbane and Women's Hospital
Hypertension, Intracranial Hemorrhage
The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy
This study is a single-arm, open label protocol evaluating the use of Cleviprex to rapidly control hypertension in patients who present with intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH), and that require ICP…
- Conditions
- Hypertension, Intracranial Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT01042574
- Testing
- Clevidipine butyrate
- Where
- United States
- Sponsor
- Methodist Healthcare - Memphis
Intraventricular Hemorrhage
Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage
Intraventricular hemorrhage comprises about 15% of the 500,000 strokes that occur annually in the United States. In the emergent setting, patients with obstructive hydrocephalus are routinely treated with placement of an external…
- Trial name
- IVH (NCT01064011)
- Testing
- Rt-PA thrombolysis, endoscopic hematoma evacuation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Albany Medical College
Subarachnoid Hemorrhage
Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage.
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating form of stroke, with delayed cerebral ischemia (DCI) as a major complication.
- Trial name
- FIVHeMA (NCT03187405)
- Testing
- EVD + IVF with Alteplase
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Cerebrospinal; Disorder
External Ventricular Drainage Post-Market Clinical Follow-up Registry
This post-market follow-up registry will capture clinical data specific to the safety and performance of the Integra External Ventricular Drainage Systems and Accessories.
- Trial name
- NCT05652296
- Testing
- External Ventricular Drainage (EVD)
- Where
- 4 sites in Belgium, France
- Volunteers
- 120 people
- Sponsor
- Integra LifeSciences Corporation
Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection
Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage
Acute hydrocephalus is a common complication following subarachnoid hemorrhage (SAH). Early and emergency insertion of external ventricular drain (EVD) is standard treatment of acute post-SAH hydrocephalus.
- Conditions
- Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection, Hydrocephalus
- Trial name
- EarlyVPS (NCT04567277)
- Testing
- External ventricular drainage (EVD) conversion into ventriculo-peritoneal shunt (VPS)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
External Ventricular Drain (EVD), Image Guidance
Image Guided EVD Placement
To determine if use of the Stryker Nav3 image guidance system offers superior results in external ventricular drain (EVD) placement compared to the standard free-hand technique.
- Trial name
- NCT05639036
- Testing
- Image Guided External Ventricular Drain Placement Using the NAV3 System, Free Hand External Ventricular Drain Placement
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
External Ventricular Drain, Intracranial Pressure
External Ventricular Drain Placement Stealth Study
External ventricular drain (EVD) placement is performed very often in neurosurgical practices. EVD's are most commonly placed at the bedside using external anatomical landmarks to guide the catheter into the frontal horn of the…
- Trial name
- NCT03696043
- Testing
- Axium Steatlh Image Guidance, EVD placement
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Intracranial Hemorrhages, Brain Injuries
Comparison of Pupilometer and Ultrasound of Optic Nerve Sheath Diameter in Estimating Intracranial Pressure (ICP)
The purpose of this investigator-initiated study is to compare the use of pupilometer and ultrasound assessment of optic nerve sheath diameter in predicting the ICP and to see if there is a value that could be used to indicate…
- Conditions
- Intracranial Hemorrhages, Brain Injuries, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CUSPICP (NCT03115450)
- Testing
- Ultrasound, Pupilometer
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Loma Linda University
Subarachnoid Hemorrhage, Aneurysmal
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs).
- Trial name
- NCT06119061
- Testing
- Telavancin Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aaron Cook
Wound Contamination
Prospective Randomised Study for Use of CHG Dressing at Entry Site of EVD's to Reduce EVD-associated Infections
The objective of this study is to assess the efficacy of 3M™ Tegaderm™ CHG I.V. Securement Dressing at the entry-site of a EVD in reducing quantity of microorganisms (CFU/cm2) after a time period of 5 days as a surrogate marker…
- Trial name
- EVDAI (NCT02078830)
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Hospital, Basel, Switzerland
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
- Trial name
- NCT05001750
- Testing
- Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Montefiore Medical Center
All Indication for External Ventricular Drain Clamping
Evaluation of pupillometrY for External Ventricular Drains Stop
Placement of an external ventricular shunt is one of the most common neurosurgical procedures in neuro-resuscitation. However, the modalities of its withdrawal are not, the subject of recommendations but rather of service habits.
- Trial name
- EYES (NCT04643717)
- Testing
- Electronic pupillometer analysis
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion