Clinical trials: External Ventricular Drainage
Infection
Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD).
Nosocomial Central Nervous System infections are difficult to treat and an early appropriate therapy can improve prognosis. The two main reasons for treatments failure are the difficulty to reach high concentrations of…
- Trial name
- NCT03481569
- Testing
- Blood and cerebrospinal fluid pharmacocinetic samples on one of the nine antibiotics prescribed in routine use
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Poitiers University Hospital
Cerebrospinal; Disorder
External Ventricular Drainage Post-Market Clinical Follow-up Registry
This post-market follow-up registry will capture clinical data specific to the safety and performance of the Integra External Ventricular Drainage Systems and Accessories.
- Trial name
- NCT05652296
- Testing
- External Ventricular Drainage (EVD)
- Where
- 4 sites in Belgium, France
- Volunteers
- 120 people
- Sponsor
- Integra LifeSciences Corporation
Brain Damage, External Ventricular Drain
Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Pupillar diameter variation to predict success or failure of external ventricular derivation clamping. Pupillometry utilisation as a diagnostic tool in external ventricular clamping test in neurological ICU should improve…
- Conditions
- Brain Damage, External Ventricular Drain, Hydrocephalus
- Trial name
- CLAMP (NCT03823430)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Association Pro-arte
Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection
Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage
Acute hydrocephalus is a common complication following subarachnoid hemorrhage (SAH). Early and emergency insertion of external ventricular drain (EVD) is standard treatment of acute post-SAH hydrocephalus.
- Conditions
- Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection, Hydrocephalus
- Trial name
- EarlyVPS (NCT04567277)
- Testing
- External ventricular drainage (EVD) conversion into ventriculo-peritoneal shunt (VPS)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Wound Contamination
Prospective Randomised Study for Use of CHG Dressing at Entry Site of EVD's to Reduce EVD-associated Infections
The objective of this study is to assess the efficacy of 3M™ Tegaderm™ CHG I.V. Securement Dressing at the entry-site of a EVD in reducing quantity of microorganisms (CFU/cm2) after a time period of 5 days as a surrogate marker…
- Trial name
- EVDAI (NCT02078830)
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Hospital, Basel, Switzerland
Intracranial Pressure Increase
Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD)
The placement of external ventricular drainage (EVD) is a life-saving procedure used to relieve high pressures in the brain. Often performed at the bedside, a small tube (catheter) is inserted into one ventricle of the brain to…
- Trial name
- NCT05931991
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
External Ventricular Drain
A Review of External Ventricular Drain Placement at the Bedside Versus Operating Room
External ventricular drain (EVD) placement is a common neurosurgical procedure and provides a way to monitor intracranial pressure.
- Trial name
- NCT06139289
- Testing
- EVD placements in the OR versus the bedside.
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Monitoring
Determination of high intracranial pressure (ICP) is necessary for the treatment of patients with raised ICP to improve long-term neurological outcomes.
- Conditions
- ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter, Intracranial Hypertension
- Trial name
- NCT06367868
- Testing
- After 5 ml CSF Drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul University - Cerrahpasa
Presence of High Intracranial Pressure
An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an External Ventricular Drainage (EVD) Device
Invasive intracranial pressure (ICP) monitoring is highly effective, but involves risks. HS-1000 measures ICP non-invasively by assessing the acoustic properties of the patient's head.
- Trial name
- NCT02284217
- Testing
- EVD
- Where
- 7 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- HeadSense Medical
Clinical Competence, Self-Confidence
Neurocritical Care Video Training in Palestine: RCT on Nursing Students' EVD Knowledge, Attitude, Skills, Confidence
This randomized controlled trial aims to evaluate the effect of a video-based educational program on nursing students' knowledge, attitude, self-reported practice, and confidence related to external ventricular drainage (EVD)…
- Conditions
- Clinical Competence, Self-Confidence, Knowledge Level
- Trial name
- NCT07284537
- Testing
- video based education, Flashcard
- Where
- Palestinian Territories
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Modern University College
Subarachnoid Hemorrhage, Hydrocephalus
Strategies for Weaning From External Ventricular Drainage
External ventricular drainage is frequently used in neurocritical care, particularly in patients admitted for non-traumatic subarachnoid hemorrhage who develop hydrocephalus and/or intracranial hypertension.
- Conditions
- Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage
- Trial name
- SEVDVE2 (NCT07630051)
- Testing
- Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Angers
Intraventricular Hemorrhage
Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage
Intraventricular hemorrhage comprises about 15% of the 500,000 strokes that occur annually in the United States. In the emergent setting, patients with obstructive hydrocephalus are routinely treated with placement of an external…
- Trial name
- IVH (NCT01064011)
- Testing
- Rt-PA thrombolysis, endoscopic hematoma evacuation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Albany Medical College
Intracranial Hemorrhages, Brain Injuries
Comparison of Pupilometer and Ultrasound of Optic Nerve Sheath Diameter in Estimating Intracranial Pressure (ICP)
The purpose of this investigator-initiated study is to compare the use of pupilometer and ultrasound assessment of optic nerve sheath diameter in predicting the ICP and to see if there is a value that could be used to indicate…
- Conditions
- Intracranial Hemorrhages, Brain Injuries, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CUSPICP (NCT03115450)
- Testing
- Ultrasound, Pupilometer
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Loma Linda University
Acute Brain Injury, Hydrocephalus
VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1.
- Conditions
- Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
- Trial name
- LACTIC (NCT07380477)
- Testing
- Sampling of blood and cerebrospinal fluid
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ventriculitis, Cerebral
Diagnostics of External Ventricular Drain Infections in Neurosurgical Patients
External ventricular drains (EVD) are small tubes used in neuro-critical care inserted to measure pressure and treat acute build-up of fluid in the brain by draining the cerebrospinal fluid (CSF) in the ventricles, often…
- Trial name
- EVD-Infect (NCT04736407)
- Testing
- Observational sampling of CSF timed around routine clinical repositioning, or not
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Karolinska University Hospital
Subarachnoid Hemorrhage, Aneurysmal
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs).
- Trial name
- NCT06119061
- Testing
- Telavancin Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aaron Cook
Head Injury, Subarachnoid Hemorrhage
Influence of Drainage on EVD ICP-signal
This observational study investigates ICP signals obtained through an external ventricular drain in the brain connected with an external transducer.
- Trial name
- NCT03164434
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
All Indication for External Ventricular Drain Clamping
Evaluation of pupillometrY for External Ventricular Drains Stop
Placement of an external ventricular shunt is one of the most common neurosurgical procedures in neuro-resuscitation. However, the modalities of its withdrawal are not, the subject of recommendations but rather of service habits.
- Trial name
- EYES (NCT04643717)
- Testing
- Electronic pupillometer analysis
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion