Clinical trials: External Ventricular Drainage
Intraventricular Hemorrhage, Cerebral Hemorrhage
Early Lumbar Drainage for Intraventricular Hemorrhage
This is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial in Chinese patients with intraventricular hemorrhage (IVH), comparing early lumbar drainage added to standard care with standard care…
- Trial name
- LD-IVH (NCT07625449)
- Testing
- Control treatment plus lumbar drainage, Control treatment schedule
- Where
- 31 sites in China
- Volunteers
- 392 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Intraventricular Hemorrhage, Lumbar Drainage
Lumbar Drainage of Intraventricular Hemorrhage
Intracerebral hemorrhage (ICH) is a debilitating and fatal disease, especially when the hemorrhage is also entering the cerebral ventricles leading to acute hydrocephalus.
- Conditions
- Intraventricular Hemorrhage, Lumbar Drainage, External Ventricular Drainage
- Trial name
- DRAIN IVH (NCT06510842)
- Testing
- External drainage of intraventricular hemorrhage
- Where
- 12 sites in Germany
- Volunteers
- 354 people
- Sponsor
- University Hospital Heidelberg
Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection
Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage
Acute hydrocephalus is a common complication following subarachnoid hemorrhage (SAH). Early and emergency insertion of external ventricular drain (EVD) is standard treatment of acute post-SAH hydrocephalus.
- Conditions
- Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection, Hydrocephalus
- Trial name
- EarlyVPS (NCT04567277)
- Testing
- External ventricular drainage (EVD) conversion into ventriculo-peritoneal shunt (VPS)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
Hydrocephalus, Critical Care
Quantitative Pupillometry
The aim of this study is to assess the diagnostic ability of quantitative pupillometry for the early detection of hydrocephalus during the weaning process of the external ventricular drain.
- Trial name
- HYDRO-NiP (NCT05386303)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Traumatic Brain Injuries, Intracranial Hypertension
Security and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain Injury
This study aims to compare the effectiveness and safety of a standard intervention called ventriculostomy for managing increased intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI).
- Trial name
- SEALS-TBI (NCT06772155)
- Testing
- Ventriculostomy, Ventriculostomy + Locking Device
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Occlusion
Comparison of EVD Catheter Diameter on Occlusion and Replacement
A randomized trial comparing small versus large catheters in terms of occlusion and need for replacement to confirm differential occlusion risk based on catheter size.
- Trial name
- NCT03248739
- Testing
- Clear Bactiseal 'large' catheter (EVD), Orange Bactiseal 'small' catheter (EVD)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Pharmacokinetics
Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Ceftolozane/tazobactam is an emerging newly available antibiotic that has a broad spectrum of activity, and could be potentially useful in the management of central nervous system infections.
- Trial name
- NCT03309657
- Testing
- Ceftolozane/tazobactam
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Royal Brisbane and Women's Hospital
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage
The DRAIN trial is an international multi-centre, 1:1 randomised, parallel-group, superiority clinical trial investigating gradual weaning vs.
- Trial name
- DRAIN (NCT03948256)
- Testing
- Control intervention, Experimental intervention
- Where
- 4 sites in Denmark, Norway
- Volunteers
- 245 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Wound Contamination
Prospective Randomised Study for Use of CHG Dressing at Entry Site of EVD's to Reduce EVD-associated Infections
The objective of this study is to assess the efficacy of 3M™ Tegaderm™ CHG I.V. Securement Dressing at the entry-site of a EVD in reducing quantity of microorganisms (CFU/cm2) after a time period of 5 days as a surrogate marker…
- Trial name
- EVDAI (NCT02078830)
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Hospital, Basel, Switzerland
External Ventricular Drain, Intracranial Pressure
External Ventricular Drain Placement Stealth Study
External ventricular drain (EVD) placement is performed very often in neurosurgical practices. EVD's are most commonly placed at the bedside using external anatomical landmarks to guide the catheter into the frontal horn of the…
- Trial name
- NCT03696043
- Testing
- Axium Steatlh Image Guidance, EVD placement
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Intracranial Hemorrhages, Brain Injuries
Comparison of Pupilometer and Ultrasound of Optic Nerve Sheath Diameter in Estimating Intracranial Pressure (ICP)
The purpose of this investigator-initiated study is to compare the use of pupilometer and ultrasound assessment of optic nerve sheath diameter in predicting the ICP and to see if there is a value that could be used to indicate…
- Conditions
- Intracranial Hemorrhages, Brain Injuries, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CUSPICP (NCT03115450)
- Testing
- Ultrasound, Pupilometer
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Loma Linda University
Hydrocephalus in Children, Regional Block
Scalp Blocks for Pediatric External Ventricular Drainage Placement
External ventricular drainage (EVD) provides cerebrospinal fluid drainage in hydrocephalus. In adults, the neurosurgeon can place EVD at the bedside.
- Conditions
- Hydrocephalus in Children, Regional Block, Pediatric Anesthesia
- Trial name
- NCT06903598
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Hande Gurbuz
External Ventricular Drain
A Review of External Ventricular Drain Placement at the Bedside Versus Operating Room
External ventricular drain (EVD) placement is a common neurosurgical procedure and provides a way to monitor intracranial pressure.
- Trial name
- NCT06139289
- Testing
- EVD placements in the OR versus the bedside.
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Intracranial Pressure Increase
Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD)
The placement of external ventricular drainage (EVD) is a life-saving procedure used to relieve high pressures in the brain. Often performed at the bedside, a small tube (catheter) is inserted into one ventricle of the brain to…
- Trial name
- NCT05931991
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Catheter Related Infections
Quality Control: A Prospective Analysis of EVD Effectiveness
The purpose and/or hypothesis: To decrease the amount of external ventricular drain (EVD) related catheter infections by comparing the efficacy of Oklahoma University Medicine standard EVD catheters, both impregnated and…
- Trial name
- NCT02484287
- Testing
- The Integra External Drainage Catheter., The Ventriclear EVD Antibiotic Catheter, The Codman Bactiseal EVD Catheter Set
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Ventriculitis, Cerebral
Diagnostics of External Ventricular Drain Infections in Neurosurgical Patients
External ventricular drains (EVD) are small tubes used in neuro-critical care inserted to measure pressure and treat acute build-up of fluid in the brain by draining the cerebrospinal fluid (CSF) in the ventricles, often…
- Trial name
- EVD-Infect (NCT04736407)
- Testing
- Observational sampling of CSF timed around routine clinical repositioning, or not
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Karolinska University Hospital
Acute Brain Injury, Hydrocephalus
VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1.
- Conditions
- Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
- Trial name
- LACTIC (NCT07380477)
- Testing
- Sampling of blood and cerebrospinal fluid
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ventricular Drain Related Infection, Nosocomial Infection
Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections
External ventricular drain infections are difficult to identify with current diagnostic methods. Initiation of antibiotic treatment is usually supported by indirect methods of bacterial infection, such as clinical signs or…
- Conditions
- Ventricular Drain Related Infection, Nosocomial Infection, Infection, Bacterial, Ventriculitis, Infectious
- Trial name
- EVD Infect II (NCT05904535)
- Testing
- Cerbrospinal fluid sampling.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Subarachnoid Hemorrhage
Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage.
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating form of stroke, with delayed cerebral ischemia (DCI) as a major complication.
- Trial name
- FIVHeMA (NCT03187405)
- Testing
- EVD + IVF with Alteplase
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen