Clinical trials: Extracorporeal CO2 Removal
Pulmonary Disease, Chronic Obstructive
Extracorporeal CO2 Removal in Hypercapnic Patients
Noninvasive ventilation represents the standard of care for patients with exacerbation of chronic obstructive pulmonary disease.
- Trial name
- NCT02564406
- Testing
- LOW FLOW EXTRACORPOREAL CO2 REMOVAL, PROLUNG ESTOR
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Roma La Sapienza
Acute Respiratory Distress Syndrome, Acute Kidney Injury
A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+
PrismaLung+ is a sterile, single-use medical device aimed at performing partial removal of carbon dioxide (CO2) from the patient's venous blood via diffusion through a membrane.
- Trial name
- SPARE (NCT07326215)
- Testing
- PrismaLung+, Invasive Mechanical Ventilation
- Where
- 10 sites in China
- Volunteers
- 99 people
- Sponsor
- Vantive Health LLC
ARDS, Human, Extracorporeal CO2 Removal
ECCO2R - Mechanical Power Study
Although mechanical ventilation remains the cornerstone of ARDS treatment, several experimental and clinical studies have undoubtedly demonstrated that it can contribute to high mortality through the developing of ventilator…
- Conditions
- ARDS, Human, Extracorporeal CO2 Removal, Mechanical Power
- Trial name
- NCT03939260
- Testing
- Extracorporeal CO2 Removal
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease
ECCO2R as an Adjunct to NIV in AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the UKs commonest chronic diseases and is responsible for a significant number of acute hospital admissions.
- Trial name
- NCT02086084
- Testing
- NIV, ECCO2R
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Renal Replacement Therapy
"Low Flow" CO2 Removal on RRT
The purpose of this study is to test the effectiveness of a membrane gas exchange device in the venovenous circulation of a continuous renal replacement therapy for the purpose of CO2 elimination and pH compensation.
- Trial name
- Prismalung (NCT02590575)
- Testing
- Extracorporeal CO2 removal with the Prismalung(R) gas exchanger on the Prismaflex(R) renal replacement platform
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pulmonary Disease, Chronic Obstructive
Extracorporeal CO2 Removal for Acute Decompensation of COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, resulting in a social and economic burden that is substantial and increasing.
- Trial name
- ORION (NCT04582799)
- Testing
- ECCO2R, NIV
- Sponsor
- University of Bologna
Acute Respiratory Distress Syndrome
Ultra-Protective Lung Ventilation With Extracorporeal CO2 Removal for Moderate ARDS
Acute respiratory distress syndrome (ARDS) accounts for 10% of all ICU admissions and for 23% of patients requiring mechanical ventilation (MV).
- Trial name
- SUPERNOVA (NCT04903262)
- Testing
- Ultraprotective ventilation with Extracorporeal CO2 removal, Conventional protective ventilation
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- University of Bologna
Acute Kidney Injury
Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows…
- Trial name
- NCT02595619
- Testing
- RRT plus ECCO2R
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Turin, Italy
Respiratory Failure, ICU
Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating ECCO2R's Efficacy and Safety in Participants With Respiratory Failure
This is an observational study performed by retrospective review of data routinely collected for patients receiving low-flow extracorporeal carbon dioxide removal (ECCO2R) therapy in intensive care units (ICUs).
- Conditions
- Respiratory Failure, ICU, Asthma (Diagnosis), ARDS
- Trial name
- NCT07161271
- Where
- Hong Kong
- Volunteers
- 59 people
- Sponsor
- Hong Kong University
Respiratory Distress Syndrome, Adult
Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS
This study evaluates the use of ultra-protective ventilation, where very low ventilation volumes are used, in patients with severe acute respiratory distress syndrome (ARDS) meeting criteria to nurse in the prone position.
- Trial name
- U-Protect (NCT02252094)
- Testing
- Prismalung, Ultra-protective ventilation, Conventional Lung Protective Ventilation
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Health System, Singapore
Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Patients With Acute Respiratory Distress Syndrome
Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units
Investigators will aim to conduct an observational study in order to assess very thoroughly all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care units of Paris and its surburb (APHP…
- Trial name
- REXECOR (NCT02965079)
- Testing
- ECCO2R
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rexecor
ARDS, Hypercapnic Respiratory Failure
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
The study aims to investigate the efficacy of extracorporeal CO2 removal for correction of hypercapnia in coronavirus disease 19 (COVID-19)-associated acute respiratory distress syndrome
- Conditions
- ARDS, Hypercapnic Respiratory Failure, AKI
- Trial name
- NCT04351906
- Testing
- ECCO2R
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Giessen
COVID-19, ECMO
Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP
assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients
- Trial name
- NCT04340414
- Testing
- Low flow ECMO driving by CVVH machine
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Lung Diseases, Obstructive
ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia
Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory…
- Trial name
- NCT04842344
- Testing
- ECCO2R
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Li Xuyan
Acute Respiratory Distress Syndrome, Acute Renal Failure
Pulmonary And Renal Support During Acute Respiratory Distress Syndrome
In patients presenting with the acute respiratory distress syndrome (ARDS), mechanical ventilation with low tidal volume (6 ml/kg predicted body weight) is the current gold standard for supportive care.
- Trial name
- PARSA (NCT01239966)
- Testing
- Combined ECCOR and RRT
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Hôpital Européen Marseille
Acute Respiratory Distress Syndrome, Lung Diseases
Extracorporeal Carbon Dioxide Removal for Acute Respiratory Distress Syndrome
To compare conventional therapy using low frequency positive pressure ventilation with extracorporeal CO2 removal for the treatment of adult respiratory distress syndrome (ARDS).
- Trial name
- NCT00000572
- Testing
- positive-pressure ventilation, extracorporeal membrane oxygenation (CO2 removal)
- Volunteers
- 40 people
- Sponsor
- Intermountain Health Care, Inc.
COPD Exacerbation
Early Extubation by ECCO2R Compared to IMV in Patients with Severe Acute Exacerbation of COPD
The study aims to investigate if veno-venous (vv)-extracorporeal carbon dioxide Removal (ECCO2R) is capable of reducing mortality and/or severe disability at day 60 after randomisation in patients with severe acute exacerbation…
- Trial name
- X-COPD (NCT03584295)
- Testing
- Extracorporeal carbon dioxide removal, Conventional Care
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Xenios AG
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Acue Respiratory Distress Syndrome
Use of Extracorporeal CO2 Removal in Case of Moderate to Severe ARDS to Apply an Ultraprotective Mechanical Ventilation Strategy
The extracorporeal CO2 removal (ECCO2R) has been recently proposed in case of Acute Respiratory Distress Syndrome (ARDS) in order to reduce pulmonary injuries induced by the mechanical ventilation.
- Trial name
- ECCO2R (NCT04556578)
- Testing
- High-flow extracorporeal CO2 removal
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Montpellier