Clinical trials: Extremity Hemorrhage
Fractures, Bone, CKD Stage 4
The Effect of Prophylactic Anticoagulation on Major Bleeding Events in Hospitalized Chronic Kidney Disease and Lower Limb Fracture Patients.
the risk of bleeding may be greater than the benefit of antithrombotic protection when prophylactically anticoagulating a patient with a lower limb fracture and advanced CKD.
- Conditions
- Fractures, Bone, CKD Stage 4, CKD Stage 3, CKD Stage 5
- Trial name
- FAA (NCT06795698)
- Testing
- Enoxaparin
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Hospital Civil de Guadalajara
Deep Vein Thrombosis of Lower Limb, Pulmonary Embolism (PE)
Deep Vein Thrombosis (DVT) Prevention in Total Hip Arthroplasty: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)
Evaluation of the safety and effectiveness of ActiveCare+ CECT device +/- baby dose aspirin (81 mg QD) for lowering the potential risk for bleeding and of DVT during and after THA surgery in comparison with LMWH.
- Conditions
- Deep Vein Thrombosis of Lower Limb, Pulmonary Embolism (PE), Bleeding
- Trial name
- SAFE (NCT00358735)
- Testing
- ActiveCare CECT device, Enoxaparin
- Where
- 9 sites in United States
- Volunteers
- 411 people
- Sponsor
- Medical Compression Systems
Bleeding
Assessment of Limb Perfusion During Junctional Tourniquet
The goal of this study is to use contrast enhanced ultrasound to determine the degree to which flow is reduced during application of a junctional tourniquet (JT).
- Trial name
- NCT02092415
- Testing
- Application of a Junctional Tourniquet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hemorrhage
Tourniquets Type Combat Application Tourniquet: Proximal or Distal Location, Simple or Staggered on Upper and Lower Limb
A tourniquet is used to stop abundant bleeding when simple compression is not effective. The investigators will study the vascular suffering of the tourniquets according to their location on the limb: limb (arm / thigh) or distal…
- Trial name
- GARROTS (NCT03218176)
- Testing
- Proximal single upper limb, Proximal staggered upper limb, Distal single upper limb
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cerebrovascular Disorders
Transcranial Stimulation for Upper Limb Training of Individuals With Sequelae From Intracranial Hemorrhage
The purpose of this study is to investigate the effect of transcranial stimulation for upper limb training of patients with sequelae from an intracranial hemorrhage.
- Trial name
- tDCS-ICH (NCT01992991)
- Testing
- Transcranial direct current stimulation
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus
Daibetic Foot
A Comparison of General Versus Peripheral Nerve Block for Lower Extremity Amputation in Diabetic Patients With Bleeding Tendency: a Retrospective Study
Retrospective data collection. The aim of this study is to compare general anesthesia and nerve block anesthesia with respect to the postoperative complications in patients undergoing diabetic leg amputation and having bleeding…
- Trial name
- NCT05012059
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Blood Loss, Surgical
Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient
investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.
- Trial name
- NCT05427513
- Testing
- Tranexamic acid injection, normal saline
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Stroke, Stiffness of Right Hand, Not Elsewhere Classified
Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
In stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living.
- Conditions
- Stroke, Stiffness of Right Hand, Not Elsewhere Classified, Muscle Tone Abnormalities, Functional; Bleeding
- Trial name
- NCT05920837
- Testing
- MyotonPRO, Box and Block Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- University of Gaziantep
Primary Total Hip and Knee Arthroplasty
Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty
This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to detect changes in coagulability following elective total knee and hip arthroplasty.
- Trial name
- NCT01809054
- Testing
- Arixtra, Pneumatic compression stockings, Aspirin
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
Hemorrhage, Hypovolemic Shock
Efficacy of Prehospital Tourniquet Models for Arterial Occlusion in Upper and Lower Limbs
The goal of this clinical trial is to compare the occlusive capability and mechanical behavior of different commercially available pre-hospital tourniquet models and the results of their application on upper and lower limbs, in…
- Conditions
- Hemorrhage, Hypovolemic Shock, Tourniquets
- Trial name
- TQ-BR (NCT06725602)
- Testing
- TQ - Proximal Application ("high and tight"), TQ - Controlled application (2-3 inches)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Hemostasis
HEMOBLAST Pilot Clinical Investigation
The primary objective of this pilot clinical investigation is to assess the reliability of the Surface Bleeding Severity Scale (SBSS) in a clinical setting.
- Trial name
- NCT02502019
- Testing
- HEMOBLAST Bellows
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Biom'Up France SAS
Arthropathy of Hip, Arthropathy of Knee
Tranexamic Acid Dosing for Total Joint Arthroplasty
The purpose of this study is to determine the effect of increasing doses of tranexamic acid (TXA) on limiting blood loss during total knee and total hip arthroplasty as defined by a change in hemoglobin from pre-operative…
- Trial name
- NCT02584725
- Testing
- Tranexamic Acid
- Volunteers
- 84 people
- Sponsor
- Columbia University
Iliofemoral Artery Injury, Shock
Posterior Tibial Artery Bypass for Iliofemoral Artery Injury Associated With Massive Blood Loss and Shock
Traumatic disruption of iliofemoral arterial segment is often associated with multiple injuries, massive hemorrhage, state of shock, and loss of blood supply to the ipsilateral lower extremity, as well as with high mortality.
- Trial name
- NCT00900848
- Volunteers
- 8 people
- Sponsor
- The Second Hospital of Qinhuangdao
Venous Thrombosis Deep (Limbs), Surgical Blood Loss
Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures
All trauma patients receive Lovenox or other prophylactic medication to prevent deep vein clots from forming. For the trauma patients with orthopedic injuries requiring surgery there is controversy over safety and efficacy when…
- Trial name
- NCT05081375
- Testing
- Enoxaparin Injectable Product, Sodium chloride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Valleywise Health
Cardiogenic Shock
HEROIC (Heparin Requirement in Counterpulsation)
Patients with intra-aortic balloon pumps (catheters placed in the groin connected to a pump which assists the heart by opening and closing a balloon in the aorta, thereby decreasing the work of the heart and improving blood flow…
- Trial name
- HEROIC (NCT00445211)
- Testing
- Heparin, Without Heparin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Corewell Health East
Aortic Valve Stenosis
Upper Extremity Versus Lower Extremity Accessory Access Sites During Transcatheter Aortic Valve Implantation
The goal of this prospective, multicenter, investigator-initiated, randomized clinical trial is to assess the safety and efficacy of a 'minimally invasive, upper extremity' approach versus the standard 'lower extremity' approach…
- Trial name
- TAVIXS (NCT05672823)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 8 sites in Netherlands
- Volunteers
- 238 people
- Sponsor
- Radboud University Medical Center
Surgical Wound Infection
Prophylactic Negative Wound Pressure Therapy (PICO-7) Following Groin Incisions in Vascular Surgery (PICO-Vasc Study)
Comparison between waterproof sterile dressing OPSITE Post-Op Visible, Smith \& Nephew, UK and PICO-7, Smith \& Nephew, UK in terms of inguinal surgical wound infection and complications after lower limb revascularization.
- Trial name
- PICO-Vasc (NCT04840576)
- Testing
- Regular waterproof sterile dressing., Prophylactic Negative Pressure Dressing
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Corporacion Parc Tauli
Vascular Trauma, Arterial Injury
An Open-label Study to Assess the Safety and Efficacy of SYMVESS® as a Vascular Conduit in Adolescents With Extremity Arterial Injury.
The goal of this study is to assess the safety and efficacy of Symvess in sexually mature adolescents (17 years of age or younger) who require a vascular conduit to repair an extremity arterial injury when autologous vein graft…
- Conditions
- Vascular Trauma, Arterial Injury, Arterial Bleeding
- Trial name
- NCT07762313
- Testing
- Acellular Tissue Engineered Vessel (Symvess)
- Volunteers
- 10 people
- Sponsor
- Humacyte, Inc.
Hemophilia A
Study of Recombinant Porcine Factor VIII (FVIII) in Hemophilia and Inhibitors to FVIII
The ability of a new recombinant porcine coagulation factor VIII, B-domain deleted (called "OBI-1"), to control the non-life- or limb-threatening bleeding episodes patients with hemophilia A commonly develop is being evaluated.
- Trial name
- NCT00245245
- Testing
- recombinant porcine coagulation factor VIII (OBI-1)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Octagen Corporation