Clinical trials: Eye
Choroidal Neovascularization, Macular Degeneration
Prospective Observational Study to Assess Effectiveness of Intravitreal Aflibercept in Patients With Wet Macular Degeneration in Greece
This is a prospective, observational, multi-center, study. The study will be conducted in approximately 12 ophthalmological clinics and practices throughout Greece.
- Trial name
- PERSEUS-GR (NCT02821247)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Greece
- Volunteers
- 119 people
- Sponsor
- Bayer
Myopia
A Comparison of Daily Disposable Contact Lenses.
This study seeks to evaluate the clinical performance of a new CE marked daily disposable contact lens that contains a wetting agent to a recently improved daily disposable contact lens.
- Trial name
- NCT00727558
- Testing
- nelfilcon A, narafilcon A
- Where
- 19 sites in United Kingdom
- Volunteers
- 248 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Uveitis, Macular Edema
Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis
The study is designed to evaluate the safety and efficacy of triamcinolone acetonide, CLS-TA, in subjects with macular edema following non-infectious uveitis.
- Conditions
- Uveitis, Macular Edema, Uveitis, Posterior, Uveitis, Anterior
- Trial name
- DOGWOOD (NCT02255032)
- Testing
- 4 mg CLS-TA, 0.8 mg CLS-TA
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clearside Biomedical, Inc.
Branch Retinal Vein Occlusion, Macular Edema
Conbercept Ophthalmic Injection for Patients With Macular Edema Caused by Branch Retinal Vein Occlusion
The purpose of this study is to verify the efficacy and safety of intravitreal injection of conbercept in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO).
- Trial name
- BRAVE (NCT03108352)
- Testing
- Conbercept ophthalmic injection
- Where
- 31 sites in China
- Volunteers
- 255 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Dry Eye Syndromes
A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi®
SIFI SpA had developed Eyestil Plus®. It is sterile eyedrops without preservatives with a physiological pH containing sodium hyaluronate.
- Trial name
- 047/SI (NCT03803748)
- Testing
- Eyestil Plus®
- Where
- 12 sites in France, Spain
- Volunteers
- 96 people
- Sponsor
- SIFI SpA
Open-angle Glaucoma, OAG
A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China
Glaucoma is the second most common cause of blindness in the world, second only to cataracts. The purpose of this study is to assess adverse events (AEs) and changes in disease activity in participants with open-angle glaucoma…
- Trial name
- NCT05821855
- Testing
- XEN45 Glaucoma Treatment System, Trabeculectomy
- Where
- 13 sites in China
- Volunteers
- 120 people
- Sponsor
- AbbVie
Dry Eye
Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye
The objective of this study is to compare the safety and efficacy of 1% MIM-D3 and 5% MIM-D3 to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT01257607
- Testing
- MIM-D3 Ophthalmic Solution
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mimetogen Pharmaceuticals USA, Inc.
Acute Adenoviral Conjunctivitis
FST-100 in the Treatment of Acute Adenoviral Conjunctivitis
This randomized, double masked, multi-center study is being conducted to support the safety and efficacy of FST-100 for the treatment of acute adenoviral conjunctivitis.
- Trial name
- NCT01470664
- Testing
- FST-100, FST-100 (Component #1), FST-100 Vehicle
- Where
- 2 sites in United States, India
- Volunteers
- 176 people
- Sponsor
- Shire
Dry Eye With Sjögren's Syndrome
A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome
The purpose of this study is to evaluate of the long-term safety and efficacy of KCT-0809 in dry eye patients with Sjögren's syndrome.
- Trial name
- NCT02503163
- Testing
- KCT-0809 ophthalmic solution
- Where
- Japan
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Open-Angle Glaucoma, Ocular Hypertension
Patient Preference Comparison of AZARGA Versus COSOPT
The purpose of this study was to assess patient preference regarding ocular comfort of AZARGA® compared to COSOPT® after one week instillation of each study medication.
- Trial name
- NCT01340014
- Testing
- Brinzolamide 1.0% + Timolol 0.5% ophthalmic suspension, Dorzolamide 2.0% + Timolol 0.5% ophthalmic solution
- Volunteers
- 112 people
- Sponsor
- Alcon Research
Sjögren's Syndrome
A Study of LY3090106 in Participants With Sjögren's Syndrome (SS)
The main purpose of this study is to learn more about the safety and side effects of the study drug known as LY3090106 in participants with Sjögren's Syndrome (SS).
- Trial name
- NCT02614716
- Testing
- LY3090106
- Where
- 7 sites in United States, Bulgaria and 2 more
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Myopia
Vistakon Investigational Lens Worn as a Single Use Daily Wear
This study is intended to show that the investigational contact lens is clinically equivalent to a currently approved contact lens, when worn as single-use on a daily basis.
- Trial name
- NCT01031004
- Testing
- narafilcon B, etafilcon A
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Age-Related (Dry) Macular Degeneration
Transpalpebral Micro-Current Electrical Stimulation for the Treatment of Dry Age-Related Macular Degeneration
Assess the effectiveness of externally applied micro current electrical stimulation on improving the ETDRS visual acuity in subjects with vision loss from dry age-related macular degeneration (AMD)
- Trial name
- NCT02540148
- Testing
- Nova Oculus™ Micro-current electrical stimulation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- The Eye Machine Canada Inc.
Cornea
Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With iVue SD-OCT
Evaluate the repeatability and reproducibility of iVue for measuring the total corneal thickness, the epithelial thickness, and the stromal thickness in normal subjects and patients with various corneal conditions.
- Trial name
- NCT02781948
- Testing
- Optical Coherence Tomography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Optovue
Cataract
Evaluation of the Safety and Effectiveness of the Akreos MI Five-0 Intraocular Lens.
The objective of this 12-month clinical investigation is to evaluate the safety and effectiveness of the Bausch \& Lomb Akreos MI Five-O intraocular lens (IOL).
- Trial name
- NCT00804726
- Testing
- Akreos MI Five-O
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract, Pseudophakia
Retrospective, Non-interventional Clinical Investigation of the Safety and Performance of 640AD Monofocal Intraocular Lens
Medicontur hydrophilic posterior chamber monofocal intraocular lens (IOL) is indicated to improve vision at far distance in adults with cataract and/or ametropia (hyperopia, myopia), secondarily to removal of the crystalline…
- Trial name
- NCT06578910
- Testing
- Standard of care, Patient satisfaction questionnare
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Medicontur Medical Engineering Ltd
Open Angle Glaucoma, Angle Closure Glaucoma
Oculusgen (Ologen) Glaucoma MMC Control in Estonia
To compare the safety and effectiveness between ologen collagen matrix and mitomycin-C (MMC) in glaucoma surgery. The ologen collagen matrix implantation procedure is same as traditional trabeculectomy except implant the ologen…
- Conditions
- Open Angle Glaucoma, Angle Closure Glaucoma, Uveitis Glaucoma, Young Age Glaucoma
- Trial name
- NCT00524758
- Testing
- ologen (oculusgen) collagen matrix, MMC in Trabeculectomy
- Where
- Estonia
- Volunteers
- 20 people
- Sponsor
- Pro Top & Mediking Company Limited
Sleep-wake Disorder in Blind Individuals
Patient Registry of Blind Subjects With Sleep-related Problems
Non-24-hour sleep-wake disorder (Non-24) is a condition experienced primarily by totally blind individuals that results in abnormal night sleep patterns and chronic daytime sleepiness.
- Trial name
- NCT01195558
- Testing
- Data collection on blindness and sleep problems
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Vanda Pharmaceuticals
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Glaucoma, Ocular Hypertension
SYL040012. Tolerance and Effect on Intraocular Pressure in Subjects With Intraocular Pressure (IOP) >= 21 mm Hg
The aim of this study is to evaluate the tolerance and effect on unmedicated subjects with elevated IOP.
- Trial name
- NCT01227291
- Testing
- SYL040012
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Sylentis, S.A.
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