Clinical trials: Eye
Low Vision, Orientation
SmartHMD for Improved Mobility
The National Eye Institute estimated about 3 million people over age 40 in the US had low vision in 2010 and projects an increase to nearly 5 million in 2030 and 9 million in 2050.
- Conditions
- Low Vision, Orientation, Mobility Limitation, Navigation, Spatial
- Trial name
- NCT03781583
- Testing
- SmartHMD version 1, SmartHMD version 2, SmartHMD version 3
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James Weiland
Blindness
Blind Elderly Melatonin Treatment Study
The primary focus of this five-year study will be to optimize the melatonin dosing regimen for synchronizing the body clocks of elderly blind individuals to the 24-hour day.
- Trial name
- NCT00692094
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Blepharitis
Comparative Study in the Efficacy of Topical Besifloxocin With Erythromycin for the Management of Acute Blepharitis
This study looks at the improvements in signs and symptoms in patients with inflammation of the lids, blepharitis, using two different FDA approved topical antibiotic agents, Besifloxocin and Erythromycin.
- Trial name
- NCT01478256
- Testing
- Erythromycin, Besifloxocin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John, George, M.D.
Acute Bacterial Conjunctivitis
Trial to Evaluate the Efficacy and Safety of IVIEW-1201 in Acute Bacterial Conjunctivitis
A Phase 2, Multi-center, Randomized, Parallel Controlled Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% Povidone-Iodine) Gel Forming Ophthalmic Solution Compared to Ofloxacin Eye Drops in the Treatment of…
- Trial name
- NCT05816070
- Testing
- IVIEW-1201, Ofloxacin Eye Drops
- Where
- China
- Volunteers
- 129 people
- Sponsor
- IVIEW Therapeutics Inc.
Dry Eye Syndrome, Keratoconjunctivitis Sicca
Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome
A Multi-Center, Phase 2/3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial to Assess the Safety and Efficacy of Voclosporin Ophthalmic Solution (0.05%, 0.10%, 0.20%) Compared to Vehicle in Subjects…
- Trial name
- AUDREY (NCT04147650)
- Testing
- 0.05% Voclosporin Ophthalmic Solution (VOS), 0.10% VOS, 0.20% VOS
- Where
- 9 sites in United States
- Volunteers
- 508 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Choroidal Neovascularization
Ranibizumab in Hemorrhagic Choroidal Neovascularization Trial
This research is being done to look at the effects of an experimental drug, ranibizumab, on a condition called "predominantly hemorrhagic subfoveal choroidal neovascularization (CNV)" due to wet age-related macular degeneration.
- Trial name
- NCT00363168
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Hyperopia
Pilot Dispensing Evaluation of a Plus Power Lens
The purpose of this study is to compare the performance of the ACUVUE® ADVANCE® Plus lenses against ACUVUE® ADVANCE® lenses in the plus power parameters.
- Trial name
- NCT01228591
- Testing
- Acuvue Advance Plus, Acuvue Advance
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Cataracts
Clinical Investigation of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
The purpose of this study is to evaluate the safety and effectiveness of an investigational multifocal toric intraocular lens (IOL) compared to an FDA-approved multifocal IOL.
- Trial name
- NCT01424189
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL, AcrySof® ReSTOR® Multifocal IOL Model SA60D3
- Volunteers
- 677 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Efficacy and Safety of T2762 and Vismed® in Dry Eye Syndrome
Comparison of the efficacy and safety of T2762 and Vismed® in the treatment of moderate to severe Dry Eye Syndrome
- Trial name
- NCT02023268
- Testing
- T2762, Vismed®
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Laboratoires Thea
Posterior Capsule Opacification, Retinal Degeneration
Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification
It has been hypothesized that potential effects of laser Nd: YAG laser posterior capsulotomy may affect macular pigment as well as choroidal thickness, macular thickness and anterior chamber parameters, so it was aimed to…
- Conditions
- Posterior Capsule Opacification, Retinal Degeneration, Retinal Detachment, Anterior Chamber Angle Congestion
- Trial name
- NCT03321253
- Testing
- Nd: YAG laser posterior capsulotomy
- Volunteers
- 38 people
- Sponsor
- Afyon Kocatepe University Hospital
Dry Eye Syndromes
An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake
To evaluate the effect of the NDE L68 StableFit® punctal plug on the tear lake.
- Trial name
- NCT04280653
- Testing
- NDE L68 StableFit® Punctal Plug
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mati Therapeutics Inc.
Non Infectious Uveitis
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye
This is a Phase III study to assess the efficacy and safety of DE-109 440 µg every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS).
- Trial name
- NCT03711929
- Testing
- DE-109 Intravitreal Injections, DE-109 Intravitreal Injections (Open Label)
- Where
- 65 sites in United States, Argentina and 2 more
- Volunteers
- 145 people
- Sponsor
- Santen Inc.
Glaucoma, Glaucoma, Open-Angle
Glaucoma Surgery Using the ViaLase Laser System
Prospective, single-center, multi-cohort clinical trial of ViaLase Laser for the reduction of IOP in patients with open angle glaucoma.
- Trial name
- NCT04949802
- Testing
- ViaLase Laser
- Where
- Hungary
- Volunteers
- 22 people
- Sponsor
- Vialase, Inc.
Exudative Age-related Macular Degeneration
Efficacy and Safety Study of iSONEP With & Without Lucentis/Avastin/Eylea to Treat Wet AMD
The purpose of the study is to determine the safety and efficacy of 4 monthly injections of iSONEP given alone or in combination with Lucentis, Avastin or Eylea in subjects with wet Age-related Macular Degeneration (AMD).
- Trial name
- Nexus (NCT01414153)
- Testing
- 4.0 mg iSONEP, 0.5 mg iSONEP, 0.5 mg Lucentis or 1.25 mg Avastin or 2 mg Eylea
- Where
- 44 sites in United States
- Volunteers
- 158 people
- Sponsor
- Lpath, Inc.
Cataract
A Comparison of Aspheric Toric Intraocular Lens (IOL) Implantation Versus Aspheric Non-Toric Lens Implantation
The purpose of this study was to evaluate and compare uncorrected distance visual acuity measurement in pseudophakic subjects with bilateral implantation of an AcrySof IQ Toric Intraocular Lens (IOL) versus bilateral implantation…
- Trial name
- NCT01225926
- Testing
- Toric T3 - T9, IQ SN60WF
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Refractive Errors, Myopia
Clinical Performance Assessment of Two Silicone Hydrogel Daily Disposable Contact Lenses
The purpose of this study is to assess the overall clinical performance of a contact lens made with a modified manufacturing process.
- Trial name
- NCT05725317
- Testing
- LID220365 contact lens, LID006961 contact lens
- Where
- 7 sites in United States
- Volunteers
- 114 people
- Sponsor
- Alcon Research
Dry Eye
Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease
The purpose of this clinical trial is to investigate the efficacy of a single iLux® treatment in symptomatic CL wearers who have DED (according to the TFOS DEWS II diagnostic criteria), of the evaporative dry eye disease subtype…
- Trial name
- SHEEPDOG (NCT04159935)
- Testing
- iLux® system
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Retinal Diseases, Telangiectasis
High-Dose Lucentis (Ranibizumab 2.0mg) for the Treatment of Nonproliferative Idiopathic Parafoveal Telangiectasia
Idiopathic Parafoveal Telangiectasia (IPT) [also known as Idiopathic Perifoveal Telangiectasia, Idiopathic Juxtafoveal Telangiectasia (IJT, JFT) and Macular Telangiectasia (MacTel)] is a disorder of unknown etiology.
- Trial name
- HD-LIPT (NCT01205035)
- Testing
- ranibizumab 2.0mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Eye Center of Northern Colorado, P.C.
Thyroid Eye Disease, Chronic (Inactive) Thyroid Eye Disease
A Study Evaluating TEPEZZA® Treatment in Patients With Chronic (Inactive) Thyroid Eye Disease
The overall objective is to investigate the efficacy, safety and tolerability of TEPEZZA® in participants with chronic (inactive) TED (thyroid eye disease). Approximately 57 participants will be enrolled.
- Trial name
- NCT04583735
- Testing
- TEPEZZA
- Where
- 12 sites in United States
- Volunteers
- 62 people
- Sponsor
- Amgen
Uveitis
Multicenter Uveitis Steroid Treatment (MUST) Trial
The purpose of this study is to compare the effectiveness of standardized systemic therapy versus fluocinolone acetonide implant therapy for the treatment of severe cases of non-infectious intermediate uveitis, posterior uveitis…
- Trial name
- MUST (NCT00132691)
- Testing
- fluocinolone acetonide intraocular implant, oral corticosteroid with immunosuppressive agents as needed
- Where
- 23 sites in United States, Australia and 1 more
- Volunteers
- 255 people
- Sponsor
- JHSPH Center for Clinical Trials
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