Clinical trials: Eye
Dry Eye Disease, Iron
A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.
This study aims to see if the amount of iron in tears is linked to how severe dry eye disease is. We hope this can lead to a new way to help diagnose and understand dry eye. This is an observational study.
- Trial name
- NCT07363824
- Testing
- Diagnostic tear fluid collection and ocular surface evaluation
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Diseases of the Circulatory System, Diseases of the Respiratory System
Assessing Feasibility of a Digital Health Intervention for Multiple Long-Term Condition Care in Primary Health Settings in India and Nepal
This observational, non-randomized, single-arm pilot study aims to assess the acceptability, feasibility, usability, and implementation fidelity of a co-designed multi-component digital health intervention to support the…
- Conditions
- Diseases of the Circulatory System, Diseases of the Respiratory System, Endocrine, Nutritional and Metabolic Diseases, Mental, Behavioral and Neurodevelopmental Disorders
- Trial name
- NIHR GHRC MLTC (NCT07400133)
- Testing
- Electronic Decision Support System (EDSS), Assisted telemedicine, Patient facing mobile app and Community champions (Care coordinators)
- Where
- 6 sites in India, Nepal
- Volunteers
- 180 people
- Sponsor
- Centre for Chronic Disease Control, India
Juvenile Open Angle Glaucoma, Dry Eye Disease (DED)
Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients.
- Conditions
- Juvenile Open Angle Glaucoma, Dry Eye Disease (DED), Interleukin 6, Retinal Nerve Fiber Layer Thickness
- Trial name
- HONEY-JOAG (NCT07396441)
- Testing
- Stingless bee honey (Kelulut)
- Where
- 4 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Dry Eye Disease (DED), Cataract
Rebamipide Versus Diquafosol for Perioperative Dry Eye in Cataract Surgery
This clinical trial is designed to compare two commonly used eye drop treatments for dry eye disease in patients undergoing cataract surgery.
- Trial name
- NCT07397949
- Testing
- Rebamipide 2% ophthalmic solution, Diquafosol 3% ophthalmic solution
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Eye-tracking, Autism Spectrum Disorder
Social COgnition Screening
Social cognition refers to the mental processes involved in social interactions, including social perception, motivation, communication, emotion recognition, and theory of mind.
- Conditions
- Eye-tracking, Autism Spectrum Disorder, Social Cognition, Diagnosis
- Trial name
- ECoS-A (NCT07377227)
- Testing
- eye-tracking, cognitive assessments
- Where
- France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Thyroid Associated Ophthalmopathies, Eye Tracking
Eye Tracking Study on Eye Movement Function and Visual Attention Patterns in Patients With Thyroid-Associated Ophthalmopathy
This study focuses on eye health and visual function in patients with Thyroid-Associated Ophthalmopathy (TAO), a condition that often causes bulging eyes and restricted eye movement.
- Trial name
- TAO-A (NCT07381413)
- Testing
- Non-invasive Eye Tracking Assessment
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Dry Eye Disease (DED) , Diabetic Macular Edema
Association Between Dry Eye Disease and Diabetic Macular Edema
This study evaluates the association between dry eye disease (DED) and diabetic macular edema (DME) in adult patients at the Ophthalmology Department, Faculty of Medicine, Sohag University.
- Trial name
- DED-DME (NCT07392307)
- Testing
- Dry Eye Disease Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Dry Eye Syndromes, Meibomian Gland Dysfunction
Mechanisms of Light-based Therapies for Dry Eye Disease
Dry eye disease is a common condition affecting millions worldwide and costing millions in healthcare due to reduced work productivity and quality of life.
- Trial name
- MOLT (NCT06004895)
- Testing
- Actual IPL, LLLT
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Aston University
Retinal Degeneration, Retinitis Pigmentosa
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F
The overall goal of this project, co-funded by the Foundation Fighting Blindness and the USHER 1F Collaborative is to characterize the natural history of disease progression in patients with PCDH15 mutations in order to…
- Conditions
- Retinal Degeneration, Retinitis Pigmentosa, Eye Diseases, Hereditary
- Trial name
- RUSH1F (NCT04765345)
- Where
- 10 sites in United States, Canada and 6 more
- Volunteers
- 44 people
- Sponsor
- Jaeb Center for Health Research
Low Vision, One Eye, Unspecified Eye, Low Vision Blindness
Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers
Investigators aim to assess the feasibility of delivering two augmentation interventions, Meditation and a Health Enhancement Program, for potentially enhancing the quality of life and mental health of Irreversible Age-Related…
- Trial name
- NCT03166072
- Testing
- Meditation, Health Enhancement Program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dry Eye Disease, oGVHD
2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD
Evaluate and study the immunologic changes to the ocular surface in cancer patients.
- Trial name
- NCT04946721
- Testing
- The standard care exam and biological specimens' collection
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sjogren Syndrome
Biopsy Based Study to Understand Mechanism of Action of Ianalumab in Salivary Glands and Explore Relationships With Clinical Assessments.
This study aims at elucidating the mechanism of action of ianalumab in salivary glands and explore relationships with clinical assessments
- Trial name
- NCT05124925
- Testing
- Ianalumab
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes
Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution
This is a comparative, open label, parallel group, non interventional study to further demonstrate the efficacy and tolerability of BAT04. In addition the efficacy and safety shall be compared to Hyaluronic acid (HA)-Product.
- Trial name
- NCT01684852
- Testing
- Medical device, drug-like
- Where
- 5 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Bitop AG
Eye Care, Nursing Care
Effects of Two Different Eye Care Practices on Eye Complications in Mechanically Ventilated Intensive Care Patients
This study was designed as a prospective, randomized controlled experimental study aiming to compare different approaches to eye care in intensive care patients receiving mechanical ventilation.
- Conditions
- Eye Care, Nursing Care, Intensive Care Unit
- Trial name
- NCT07070843
- Testing
- Control Group: Standard Eye Care Group, Intervention Group 1: Eye Care Using an Eye Care Kit, Intervention Group 2: Eye Care According to an Eye Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Istanbul Saglik Bilimleri University
Dry Eye Disease (DED)
Efficacy and Safety of VMX Eye Drops for Dry Eye Disease
This multicenter, randomized, double-blind study evaluates the safety and effectiveness of VMX eye drops in patients with dry eye disease.
- Trial name
- NCT07369375
- Testing
- VMX Eye Drops
- Volunteers
- 76 people
- Sponsor
- VISUfarma SpA
Dry Age-related Macular Degeneration, Macular Degeneration
FOCUS: A Phase I/II First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects With Dry AMD
This was an open label first in human Phase I/II multicentre study of GT005 in subjects with Macular Atrophy due to Age-related macular degeneration (AMD).
- Conditions
- Dry Age-related Macular Degeneration, Macular Degeneration, Retinal Disease, Eye Diseases
- Trial name
- NCT03846193
- Testing
- GT005, GT005 / Device: Orbit™ Subretinal Delivery System
- Where
- 13 sites in United States, United Kingdom
- Volunteers
- 56 people
- Sponsor
- Gyroscope Therapeutics Limited
Dry Age-related Macular Degeneration
HORIZON: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
The purpose of this clinical study was to evaluate the safety and efficacy of two doses of GT005 administered as a single subretinal injection in subjects with geographic atrophy secondary to age-related macular degeneration…
- Trial name
- NCT04566445
- Testing
- GT005
- Where
- 62 sites in United States, Australia and 5 more
- Volunteers
- 255 people
- Sponsor
- Gyroscope Therapeutics Limited
The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing
Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars.
- Trial name
- NCT07318298
- Testing
- Surgical extraction of wisdom teeth, bone biobsy
- Where
- Jordan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dry Age-related Macular Degeneration
EXPLORE: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
The purpose of this clinical study was to evaluate the safety and efficacy of two doses of GT005 administered as a single subretinal injection in subjects with geographic atrophy secondary to age-related macular degeneration…
- Trial name
- EXPLORE (NCT04437368)
- Testing
- GT005
- Where
- 55 sites in United States, Australia and 6 more
- Volunteers
- 98 people
- Sponsor
- Gyroscope Therapeutics Limited
Dry Eye, Neuropathic Pain
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.
- Trial name
- NASA (NCT04838223)
- Testing
- Hyperosmolar Response, Proparacaine Challenge Test, Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
- Where
- 16 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tufts Medical Center