Clinical trials: Eye, open to volunteers
Orthopedic Surgery, Nursing Care
Effect of Earplugs and Eye Masks Used After Orthopedic Surgery on Comfort and Quality of Recovery
This research will be conducted as a randomized controlled trial to determine the effects of earplugs and eye masks used after orthopedic surgery on comfort and quality of recovery.
- Conditions
- Orthopedic Surgery, Nursing Care, Quality of Recovery 40, Comfort
- Trial name
- NCT06986408
- Testing
- Earplugs and Eye Masks
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Proliferative Vitreoretinopathy
Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR).
- Trial name
- NCT07682025
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Myopia, Myopia Progression
Evaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children
This clinical study aims to evaluate the non-inferiority of the photochromic DIMS spectacles lenses performance (PDIMS) compared to clear DIMS spectacles lenses (DIMS) in myopia management.
- Trial name
- PDIMS (NCT06717035)
- Testing
- EYE001
- Where
- Singapore
- Volunteers
- 202 people
- Sponsor
- Singapore National Eye Centre
MS (Multiple Sclerosis), NMO Spectrum Disorder (NMOSD)
Multiple Sclerosis Versus Neuromyelitis Optica Spectrum Disorder
The aim of this work is to do a detailed comparison between multiple sclerosis and Neuromyelitis Optica Spectrum Disorder due to delicate similarities between both diseases and wide rang of management and follow up of the patients
- Trial name
- NCT07304960
- Volunteers
- 100 people
- Sponsor
- Assiut University
Keratoconus, Unstable, Bacterial Keratitis
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Trial name
- NCT03918408
- Testing
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Pacific Clear Vision Institute
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Geographic Atrophy, Age - Related Macular Degeneration (AMD)
An Open-label Safety, Tolerability and Exploratory Efficacy Clinical Trial of PST-611 in Geographic Atrophy
The goals of this interventional study are (1) to evaluate the safety and tolerability of multiple doses of PST-611 in men and women over the age of 65 with geographic atrophy secondary to age-related macular degeneration and (2)…
- Trial name
- NCT07705568
- Testing
- PST-611
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Eyevensys
Myopia, Myopic Astigmatism
A Clinical Trial Assessing the Safety and Effectiveness of Orthokeratology Lenses in Patients With Myopia and Myopic Astigmatism
This is a prospective, multi-centre, single-arm clinical trial to evaluate the effectiveness and safety of MCOK-01 lenses in patients with myopia and myopic astigmatism who need dioptric correction.
- Trial name
- SEMOA (NCT07047924)
- Testing
- MCOK-01
- Where
- 4 sites in Australia
- Volunteers
- 220 people
- Sponsor
- Menicon Co., Ltd.
Age-Related Macular Degeneration
Impact of Age-related Macular Degeneration on Daily Living Activitie
The complex and variable course of age-related diseases makes it all the more necessary to carry out personalised, reasoning-based examinations to improve the personalised assessment and management of AMD.
- Trial name
- AMDAY (NCT06333873)
- Testing
- patient-reported outcome
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Metabolic Syndrome, Behcet Disease
Efficacy of Physical Activity Program in Metabolic-syndrome Females With Behcet Disease
metabolci syndrom is highly prevalent in behcet disorder females. usually physical activity is recommended to solve this problem
- Trial name
- NCT07702123
- Testing
- treadmill walking
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Advanced Solid Tumors
Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving REGN13089-M404-M2980, an Antibody-drug Conjugate That Targets MET Protein on Tumors
This study will test a Regeneron drug called REGN13089-M404-M2980 ("study drug") to see if it can help treat previously treated, advanced solid tumors (tumors that have grown and spread to different areas of the body).
- Trial name
- NCT07863024
- Testing
- REGN13089-M404-M2980
- Volunteers
- 320 people
- Sponsor
- Regeneron Pharmaceuticals
Myopia
Myopia Prevention With Reading Glasses
The last decades have seen a significant increase in myopia in children and young adults. Possible cause: increased near-work (school, computer, smartphone).
- Trial name
- SMART2 (NCT05030103)
- Testing
- Reading glasses, +2.0 diopters
- Where
- Liechtenstein
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Reis Augenklinik AG
Eye Diseases, Healthy Volunteers
Adaptive Optics Retinal Imaging
Background: By the time diseases of the retina are detected, serious damage has often already been done. Researchers want to find better ways of viewing the retina. One way called adaptive optics may help detect problems earlier.
- Trial name
- NCT02317328
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Presbyopia
Luminous Efficiency Function V(λ)' of Patients That Underwent Pseudophakic Presbyopic Corrections With EDOF IOLs
Primary objective of this study is to introduce a modified luminous efficiency function that addresses the distinct total eye light transmittance of patients who underwent pseudophakic presbyopic correction with extended-depth of…
- Trial name
- V(λ)'_EDOF (NCT07077967)
- Testing
- Phacoemulsification with EDOF IOLs
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Retinitis Pigmentosa
BS01 in Patients With Retinitis Pigmentosa
A Phase 1/2, Safety and Efficacy Trial of BS01, a Recombinant Adeno-Associated Virus Vector Expressing ChronosFP (AAV2-CAG-ChronosFP) in Patients with Retinitis Pigmentosa
- Trial name
- NCT04278131
- Testing
- BS01
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bionic Sight LLC
Graves Disease, Mental Fatigue
Validating Immunological Markers Associated With Mental Fatigue in Graves' Disease
Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored euthyroidism in Graves' disease is an autoimmune complication.
- Trial name
- NCT06081439
- Where
- Sweden
- Volunteers
- 430 people
- Sponsor
- Vastra Gotaland Region
Retinitis Pigmentosa
The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa
The aim of this study is to determine whether 9-cis-beta Caroten rich D. Brdawiil extract is effective in the treatment of retinitis pigmentosa in adolescent patients.
- Trial name
- NCT02018692
- Testing
- Alga Dunaliella Bardawil powder
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Uveal Melanoma
Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma
This is a phase II open-label, single-arm, multi-center study of tebentafusp in HLA- A*0201 positive previously untreated (1L) untreated metastatic uveal melanoma (mUM) with an integrated circulating tumor DNA (ctDNA) biomarker.
- Trial name
- NCT06070012
- Testing
- Tebentafusp
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Diwakar Davar
Autism, Infant Development
Screening for Autism in 9-Month-Olds by Measuring Social Visual Engagement
The goal of this project is to measure the clinical utility of an objective and quantitative eye-tracking assay collected on a standalone, mobile investigational device to accurately screen 9-month-old infants for autism spectrum…
- Trial name
- NCT05916430
- Testing
- EarliPoint Investigational Device
- Where
- 2 sites in United States
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- Emory University
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