Clinical trials: Eye
Primary Open-angle Glaucoma
Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients
Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy.
- Trial name
- NCT02077231
- Testing
- Vitamin A, carbomer eye gel
- Volunteers
- 30 people
- Sponsor
- Xiaodong Zhou
Diabetes Mellitus, Diabetic Retinopathy (DR)
Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply Side
The goal of this clinical trial is to determine whether integration of vision care into the DM treatment system, by providing specific recommendations to doctors for management of diabetes alongside feedback on positive eye exams…
- Trial name
- NCT06968637
- Testing
- care recommendations
- Where
- 2 sites in Bangladesh
- Volunteers
- 336 people
- Sponsor
- Orbis
Cataract, Astigmatism
Conventional Surgery vs. Verion/VerifEye
Nowadays cataract patient's expectations are closer to those of refractive surgery patients. Patients want to be spectacle independent.
- Trial name
- NCT02513745
- Testing
- Conventional, Refractive Cataract Suite (Verion + ORA)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Chalazion
Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery
This randomized controlled trial aims to compare the effectiveness and safety of 6% versus 8% sevoflurane inhalation induction in pediatric patients undergoing minor ophthalmic surgery.
- Trial name
- SEVO-PED (NCT07450495)
- Testing
- Sevoflurane
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Allergic Conjunctivitis
Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model
The purpose of this study is to evaluate the effectiveness of the modified Conjunctival Allergen Challenge (CAC) and observe how the produced allergic inflammation reacts to treatment with a proven ocular anti-inflammatory…
- Trial name
- NCT01534195
- Testing
- Prednisolone Sodium Phosphate Ophthalmic Solution 1%, Tears Naturale II Ophthalmic Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- ORA, Inc.
Cornea, Keratoconus
Corneal Transplantation Guided by OCT RESCAN
The investigators will evaluate 30 patients with surgical indication for corneal transplantation. Participants will be divided according to the following diseases diseases: keratoconus, bullous keratopathy, corneal dystrophies.
- Conditions
- Cornea, Keratoconus, Bullous Keratopathy, Corneal Dystrophy
- Trial name
- NCT02736877
- Testing
- Lumera Microscope with OCT RESCAN, Conventional Microscope
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Cataract, Intraocular Pressure
High Intraocular Pressure After Cataract Surgery
Effectiveness of anterior chamber drainage on the structure of the anterior chamber, the position of the intraocular lens and the shape of the corneal incision in the early stage of cataract surgery with high intraocular pressure
- Trial name
- NCT05834465
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Graft Versus Host Disease in Eye, Ocular Complications
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and…
- Conditions
- Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease
- Trial name
- NCT06874283
- Testing
- Eye exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery
This randomized, controlled clinical trial investigates the perioperative use of low-level light therapy (LLLT) to prevent or reduce signs and symptoms of dry eye disease (DED) in patients undergoing cataract surgery.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease
- Trial name
- LLLT-Cataract (NCT07067294)
- Testing
- Low-Level Light Therapy
- Where
- Romania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Retinal Disease
Navigated OCT Imaging With the P200TxE
The P200TxE will be used to obtain peripheral OCT (optical coherence tomography) images.
- Trial name
- NCT04003831
- Testing
- Device: P200TxE
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Optos, PLC
Soft Contact Lenses, Myopia
DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin
This is a prospective, single center, randomized, bilateral crossover, dispensing clinical trial to evaluate the effects of the water gradient lens, DAILIES TOTAL1, on the biology of corneal epithelium over two months of daily…
- Trial name
- TruEyeTotal1 (NCT02347631)
- Testing
- Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye, Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma
Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye
This randomized phase II trial studies temozolomide to see how well it works compared to selumetinib in treating patients with melanoma of the eye that has spread to other places in the body.
- Conditions
- Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma, Ocular Melanoma With Extraocular Extension, Recurrent Uveal Melanoma
- Trial name
- NCT01143402
- Testing
- Dacarbazine, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 33 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Dry Eye Disease (DED)
The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes
Dry eye disease (DED) is a common, long-lasting condition that affects the surface of the eye. It happens when there's a problem with tear production or quality, which can lead to inflammation and discomfort.
- Trial name
- NCT06898853
- Testing
- 0.1% Ciclosporin A eye drops, Mineral oils eye drops
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of New South Wales
Cataract
Spherical Aberration and Contrast Sensitivity Function in Eyes Implanted With Spherical and Aspheric Intraocular Lenses: A Clinical Trial
Aspheric intraocular lenses can effectively reduce higher-order aberrations and improve contrast sensitivity function after cataract surgery.
- Trial name
- NCT01028872
- Testing
- Intraocular lens
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Vision Disorders, Ocular Surface Disease
Optic Nerve Diameter and Intraocular Pressure Changes in Patients Undergoing Vitrectomy Under General Anesthesia
This study aimed to measure optic nerve sheath changes in the intraoperative period in patients who underwent vitrectomy surgery and to investigate the intraoperative factors that may affect this.
- Trial name
- NCT05195801
- Testing
- USG
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Akdeniz University
Neuromyelitis Optica
Evaluate the Safety and Efficacy of CAR-T Cells in the Treatment of R/R Neuromyelitis Optica
This is a single-arm, open-label, single-center, phase I study. The primary objective is to evaluate the safety of CD19 CAR-T therapy for patients with relapsed or refractory Neuromyelitis Optica, and to evaluate the…
- Trial name
- NCT05828212
- Testing
- CAR-T cells injection
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Myopia
Comparison of Verofilcon A Daily Disposable Lenses to Somofilcon A Daily Disposable Lenses
The objective of the study is to evaluate and compare the performance of verofilcon A to somofilcon A when worn on a daily disposable modality over a period of approximately one week each.
- Trial name
- NCT04305912
- Testing
- somofilcon A, verofilcon A
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Unstable Corneas
Corneal Cross-Linking Comparing Variables
The purpose of this study is to evaluate the Safety and Efficacy of Corneal Cross Linking in a Continuous Beam versus Pulsed Treatments across epithelium on and epithelium off surfaces.
- Trial name
- NCT02095730
- Testing
- Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Crowd Health Research, LTD
Acute Disseminated Encephalomyelitis, Devic's Syndrome
Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone
OBJECTIVES: I. Evaluate the effectiveness of plasma exchange in the treatment of acute severe attacks of inflammatory demyelinating disease in patients who have failed intravenous steroid therapy.
- Conditions
- Acute Disseminated Encephalomyelitis, Devic's Syndrome, Marburg's Variant of Multiple Sclerosis, Balo's Concentric Sclerosis
- Trial name
- NCT00004645
- Testing
- Plasma exchange
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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