Clinical trials: Eye
Meibomian Gland Dysfunction
Methods to Enhance AZR-MD-001 for Meibomian Gland Dysfunction (MGD)
Single-center, single-masked (the individual(s) performing efficacy and safety measures will be masked to treatment assignment for the patient(s) they are assessing), vehicle-controlled, randomized study.
- Trial name
- NCT04314362
- Testing
- AZR-MD-001 ointment/semi-solid drug
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- Azura Ophthalmics
Neovascular Glaucoma
Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma
This 52 week study will assess the use of intravitreal aflibercept injections in patients with neovascular glaucoma (NVG) compared to standard of care panretinal photocoagulation.
- Trial name
- NCT01711879
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Meibomian Gland Dysfunction, Dry Eye
Meibomian Gland Dysfunction Treatment
The purpose of this study is to evaluate the effectiveness of treatments for Meibomian Gland Dysfunction.
- Trial name
- NCT04229888
- Testing
- LipiFlow
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Open Angle Glaucoma
Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery
To compare the safety and effectiveness of oculusgen (ologen) collagen matrix implantation and Mitomycin-C(MMC) in glaucoma surgery.
- Trial name
- NCT00538590
- Testing
- Collagen Matrix in Glaucoma Filtering Surgery, Mitomycin-C(MMC) and glaucoma filtering surgery
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Pro Top & Mediking Company Limited
Diabetic Retinopathy
A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin)
This study will provide preliminary data on the dose and dose interval related effects of intravitreally administered Avastin on retinal thickness and visual acuity in subjects with Diabetic Macular Edema (DME) to aid in planning…
- Trial name
- Bevacizumab (NCT00336323)
- Testing
- Laser Photocoagulation, Bevacizumab
- Where
- 34 sites in United States
- Volunteers
- 121 people
- Sponsor
- Jaeb Center for Health Research
Cataract
Galilei Lens Professional vs. Predicate Devices: a Comparison Study
Study question: How does the new GALILEI Lens Professional compare to predicate devices? Study hypothesis: The GALILEI Lens Professional achieves a better precision in the postoperative, calculated target refraction with cataract…
- Trial name
- NCT01961089
- Testing
- Galilei Lens Professional, IOLMaster, Lenstar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ziemer Ophthalmic Systems AG
Glaucoma
Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma
The primary objective of the study is to assess the safety and tolerability of a 180μg/ml TID dose regimen of recombinant human nerve growth factor (rhNGF) eye drop solution administered over 8 weeks versus a vehicle control in…
- Trial name
- NGF-Glaucoma (NCT02855450)
- Testing
- rhNGF, Vehicle
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dompé Farmaceutici S.p.A
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Inflammation, Pain
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation Following Cataract Surgery
The objective of this study is to compare the safety and efficacy of Mapracorat Ophthalmic Suspension, 3% to vehicle for the treatment of postoperative inflammation and pain following cataract surgery.
- Conditions
- Inflammation, Pain, Cataract
- Trial name
- NCT01298752
- Testing
- Mapracorat, Vehicle
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Bausch & Lomb Incorporated
Tinnitus
A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom
The purpose of this study is to determine the feasibility and effectiveness of a CBT-based internet intervention for adults with tinnitus in the United Kingdom
- Trial name
- NCT02370810
- Testing
- CBT-based internet-intervention for tinnitus
- Where
- United Kingdom
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Posterior Blepharitis
Oral Azithromycin Versus Doxycycline in Posterior Blepharitis
One hundred patients with the diagnosis of posterior blepharitis based on history taking and proper physical examinations by two experienced ophthalmologists will include in the study.
- Trial name
- NCT01783860
- Testing
- Azithromycin, Doxycycline
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Presbyopia, Astigmatism
Clinical Evaluation of Investigational Multifocal Toric Contact Lenses
This non-dispensing study is to evaluate the clinical performance of a test multifocal toric silicone hydrogel contact lens compared to a marketed multifocal toric contact lens (control).
- Trial name
- NCT03519282
- Testing
- comfilcon A multifocal toric lens, omafilcon A Multifocal Toric Lens
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- CooperVision, Inc.
Trichiasis, Surgery
Maximizing Trichiasis Surgery Success
The purpose of this study is to determine whether the rate of post-operative trachomatous trichiasis differs significantly between bilamellar tarsal rotation surgery with an incision height of 3 mm, bilamellar tarsal rotation…
- Trial name
- MTSS (NCT03100747)
- Testing
- Bilamellar 3 mm, Bilamellar 5 mm, Trabut 3 mm
- Where
- Ethiopia
- Volunteers
- 4,914 people
- Sponsor
- University of North Carolina, Chapel Hill
Macular Degeneration
A Study to Test How Well Different Doses of BI 754132 Are Tolerated in Patients With an Advanced Form of Age-related Macular Degeneration Called Geographic Atrophy
This is a study in adults with geographic atrophy, an advanced form of age-related macular degeneration. The purpose of this study is to find out how well different doses of BI 754132 are tolerated.
- Trial name
- NCT04002310
- Testing
- BI 754132
- Where
- 13 sites in United States, United Kingdom
- Volunteers
- 18 people
- Sponsor
- Boehringer Ingelheim
Primary Open-angle Glaucoma and Ocular Hypertension
DE-117 Spectrum 5 Study
Santen will evaluate the intraocular pressure (IOP) lowering effect and efficacy of DE-117 ophthalmic solution 0.002% in latanoprost low/non-responder subjects diagnosed with POAG or OHT
- Trial name
- NCT03697811
- Testing
- DE-117 Ophthalmic Solution
- Where
- 32 sites in United States
- Volunteers
- 107 people
- Sponsor
- Santen Inc.
Glaucoma
COSOPT-S® Treatment Versus Acetazolamide Before Trabeculectomy
The most common cause of post-trabeculectomy filtration failure is postoperative scarring. Long-term preoperative treatment with local antiglaucoma agents containing preservatives has an increased risk of post-operative scarring…
- Trial name
- NCT01228149
- Testing
- Trabeculectomy with preoperative Diamox/DexaEDO treatment, Trabeculectomy with preoperative Cosopt S treatment
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Katrin Lorenz
Macular Degeneration
12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD)
The purpose of this 12 week, open-label study is to investigate the safety and efficacy of a single dose regimen of pazopanib eye drop for neovascular AMD.
- Trial name
- NCT01362348
- Testing
- pazopanib eye drops
- Where
- 15 sites in United States, France and 1 more
- Volunteers
- 19 people
- Sponsor
- GlaxoSmithKline
Cataract
Clinical Investigation of the Next-Generation Intraocular Lens
This study is a 6-month, prospective, multicenter, bilateral, randomized clinical investigation of the TECNIS Model ZHR00 and Model ZQR00 IOLs versus the TECNIS Symfony control IOL.
- Trial name
- NCT03111550
- Testing
- Investigational Intraocular Lens Device #1: TECNIS Model ZHR00, Investigational Intraocular Lens Device #2: TECNIS Model ZQR00, TECNIS Symfony® Extended Range of Vision Intraocular Lens: Model ZXR00
- Where
- 12 sites in United States
- Volunteers
- 242 people
- Sponsor
- Abbott Medical Optics
Glaucoma, Open-Angle, Ocular Hypertension
Performance of the Travoprost Intraocular Implant
To evaluate the performance of the Travoprost Intracameral Implant by determining residual drug in explanted implants of the Travoprost Intracameral Implant and by determining aqueous humor concentrations of travoprost free acid…
- Trial name
- NCT06582732
- Testing
- Travoprost Intracameral Implant exchanged at Month 12, Travoprost Intracameral Implant exchanged at Month 3, Travoprost Intracameral Implant exchanged at Month 6
- Where
- Armenia
- Volunteers
- 210 people
- Sponsor
- Glaukos Corporation
Age Related Macular Degeneration
Efficacy and Safety of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)
The study will test if the efficacy and safety of an alternative dosing regimen is as effective as monthly injections.
- Trial name
- EXCITE (NCT00275821)
- Testing
- Ranibizumab 0.3 mg - 3 times monthly, then quarterly, Ranibizumab 0.5 mg - 3 times monthly, then quarterly, Ranibizumab 0.3 mg monthly
- Where
- Switzerland
- Volunteers
- 353 people
- Sponsor
- Novartis
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