Clinical trials: Eye Disorders
Hyperopia
Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of hyperopia, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00762281
- Testing
- MEL 80 Hyperopic LASIK Treatment
- Where
- 6 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Presbyopia, Pseudophakia
Pilocarpine and Brimonidine in Patients With Monofocal Lenses
The current study aims to assess the use of pilocarpine and brimonidine to improve near visual acuity in patietns with monofocal intraocular lenses.
- Trial name
- NCT03825081
- Testing
- Brimonidine, pilocarpine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Keratoconus
Customized Contact Lenses
The overall goal of this project is to improve the visual quality of individuals who have abnormal corneal conditions that alter the shape of their cornea (eg. keratoconus).
- Trial name
- NCT05134909
- Testing
- Customized contact lens
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Houston
Retinal Disease
Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
- Trial name
- NCT02811536
- Testing
- optical coherence tomography angiography
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cataract
Clinical Investigation of the Next-Generation Intraocular Lenses
This study is a 6-month, prospective, multicenter, subject/evaluator-masked, bilateral, randomized clinical investigation of the TECNIS Next-Generation Model ZFR00 and Model ZYR00 IOLs versus the TECNIS Multifocal Model ZLB00…
- Trial name
- NCT03372434
- Testing
- Investigational Intraocular Lens Device #1: Model ZFR00, Investigational Intraocular Lens Device #1: Model ZYR00, TECNIS Multifocal Intraocular Lens: Model ZLB00
- Where
- 12 sites in United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Macular Degeneration
Oxidative Stress in Patients With Age-Related Macular Degeneration
First, to quantify, by means of comet assay analysis, systemic oxidative stress in patients with non-exudative and exudative age-related macular degeneration (AMD) and compare results to healthy controls.
- Trial name
- NCT00465400
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cataract
Long-term With a Trifocal Intraocular Lens
The main aims of this study were to evaluate the patient reported outcomes (PROs), safety and efficacy, after 6-year (66 - 78 months) from the binocular implantation of the AT LISA tri 839MP.
- Trial name
- NCT04861909
- Testing
- AT LISA tri 839MP
- Where
- Spain
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Qvision, Ophthalmology Department
Presbyopia
Post-Approval Study With the KAMRA Inlay
KAMRA inlay, to be unilaterally implanted into the cornea of a subject's non-dominant eye. The inlay is to be inserted into a stromal pocket created with a surgical femtosecond laser.
- Trial name
- NCT03173664
- Testing
- KAMRA Inlay
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
Colorectal Cancer, Adenoma
G-Eye Advanced Colonoscopy For Increased Polyp Detection Rate-randomized Tandem Study With Different Endoscopist
The purpose of this study is to compare the adenoma detection rate of G-EYE™ high definition colonoscopy with that of standard high definition colonoscopy.
- Trial name
- NCT02066064
- Testing
- Standard Colonoscopy, G-EYE(TM) Colonoscopy
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Cataract
Evaluation the TECNIS IOL in Both Eyes VS the ReZoom IOL in One and TECNIS IOL in the Opposite
The purpose of this study is to evaluate the visual performance of two cohorts of patients who received multifocal intraocular lenses following cataract and clear lens extraction surgeries.
- Trial name
- NCT01253239
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Myopia, Astigmatism
Z8 OCT-controlled 2D vs 3D LASIK
The aim of this study was to test the hypothesis that OCT-guided 110 µm targeted flaps will result in accurate, predictable, and precise thickness flaps, with low complication rates when performed and compared using both 2D and…
- Trial name
- NCT04426175
- Testing
- 2D and 3D cutting method using a low energy Femtosecond laser LDV Z8 for LASIK flap cutting
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Zentrumsehstarke Hamburg
Proliferative Vitreoretinopathy
Isotretinoin for Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR), or secondary scarring on and around the retina, is an important cause of retinal re-detachment.
- Trial name
- DELIVER (NCT01445028)
- Testing
- Isotretinoin
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Dry Eye Syndromes
An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake
To evaluate the effect of the NDE L68 StableFit® punctal plug on the tear lake.
- Trial name
- NCT04280653
- Testing
- NDE L68 StableFit® Punctal Plug
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mati Therapeutics Inc.
Normal Healthy Subjects With No Known Ocular Diseases, Glaucomatous Eyes
Clinical Study of the Optic Disc Parameters
Assess the repeatability and agreement of the Optic Disc Parameters, Retinal Nerve Fiber Layer (RNFL) Thickness, and Full Retinal Thickness between the Maestro and iVue OCT devices
- Conditions
- Normal Healthy Subjects With No Known Ocular Diseases, Glaucomatous Eyes, Eyes With Retinal Diseases
- Trial name
- NCT02277119
- Testing
- Maestro, iVue
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Ophthalmopathy
Effect Of Reusing the Operative Supplies On Cataract Surgery and Climate Change
Although postoperative infectious endophthalmitis and toxic anterior segment syndrome (TASS) rarely happen, they can threaten sight and are considered complications of intraocular and cataract surgery1.
- Trial name
- NCT06102265
- Testing
- sterilization
- Where
- 2 sites in Egypt
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sohag University
Strabismus
Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia
Infantile esotropia is corrected in most cases by bilateral recession of the medial rectus muscles (BR) or by unilateral recession of the medial rectus muscle and resection of the lateral rectus muscle (RR).
- Trial name
- NCT00304577
- Testing
- Bilateral recession, Unilateral recession and resection
- Where
- 12 sites in Germany, Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Alzheimer Disease, Healthy Volunteers
Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]MNI-958, a tau targeted PET radioligand, in individuals with Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP), and healthy volunteers (HV).
- Conditions
- Alzheimer Disease, Healthy Volunteers, Progressive Supranuclear Palsy
- Trial name
- NCT03058965
- Testing
- [18F]MNI-958, [18F]Florbetapir, DaTscan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Eye Strain, Eye Strain of Both Eyes
Study of Non-inferiority Between Manzanilla Sophia® and Meticel Ofteno® 0.5% for Providing a Soothing Sensation to the Eyes.
This is a phase IV clinical study to demonstrate the non-inferiority of Manzanilla Sophia® compared to Meticel Ofteno® 0.5% in providing restful sensation to the eyes.
- Trial name
- NCT06373653
- Testing
- Manzanilla Sophia®, Meticel Ofteno®
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Eye Diseases, Retinal Disease
Advancing Pediatric Retinal Imaging With Auto-aligned OCT
The goal of the current study is to conduct a pilot study to test a new version of the handheld OCT device capable of auto-alignment to image the retina in adult volunteers, and adult and pediatric patients in clinic.
- Conditions
- Eye Diseases, Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06841575
- Testing
- Auto-aligned OCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
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