Clinical trials: Facial Transplantation
Facial Trauma, Facial Deformity
Face Transplantation
Face allotransplantation will be performed in facial trauma patients. Immune suppression will primarily be provided according to standard three-drug regimen.
- Conditions
- Facial Trauma, Facial Deformity, Facial Injuries
- Trial name
- NCT05699187
- Testing
- Face allotransplantation
- Sponsor
- Massachusetts General Hospital
Transplantation: Facial Transplantation
Face Transplantation
This study aims to: 1. Perform face transplants on people who have suffered severe facial trauma with tissue and functional loss; and 2. Evaluate the acceptance and function of the transplanted tissue.
- Trial name
- NCT01140087
- Testing
- Face Transplant
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Maryland, Baltimore
Severe Facial Deformities
Face Transplantation Clinical Trial
The purpose of this study is to apply human facial allograft transplant to the subjects with severe facial deformities or disfigurements in order to provide adequate coverage, aesthetic appearance and functional outcome.
- Trial name
- NCT01269164
- Testing
- Surgical Procedure Composite Facial Transplant
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Severe Facial Deformity
Face Transplantation for Treatment of Severe Facial Deformity
Face transplantation surgery is the transfer of face tissue from a deceased human donor to a patient with a severe facial deformity.
- Trial name
- NCT01281267
- Testing
- Facial Allograft Transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Face Injuries, Hand Injuries
Craniomaxillofacial and Upper Extremity Allotransplantation
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional…
- Conditions
- Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries
- Trial name
- NCT04057638
- Testing
- Combined Craniomaxillofacial and Upper Extremity Allotransplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Reconstruction of the Face
Face Reconstruction by Allotransplantation of Composite Tissues
To show the feasibility of face transplantation in patients
- Trial name
- NCT00527280
- Testing
- Feasibility ot face transplantation
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Corneal Scars and Opacities
To Evaluate the Clinical Safety and Efficacy of Limbal Stem Cell for Treatment of Superficial Corneal Pathologies".
This study proposes to investigate the transplantation of ex-vivo cultivated allogenic limbal stromal cells for the treatment of the corneal pathologies.
- Trial name
- NCT04932629
- Testing
- Ex-vivo cultivated Allogeneic limbal stromal stem cells
- Volunteers
- 20 people
- Sponsor
- L.V. Prasad Eye Institute
Actinic Keratosis
Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients
This is a single arm, open-label interventional study of ingenol mebutate 0.015% in solid organ transplant recipients. The investigators plan to treat 20 subjects, 10 kidney transplant recipients and 10 lung transplant…
- Trial name
- NCT02866695
- Testing
- ingenol mebutate gel 0.015%
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Breast Hypoplasia and Facial Ageing
Cosmetic Fat Transplantation Using Expanded ASC Enriched Fat Grafts
The purpose of the present study is to examine whether enrichment of a fat graft with autologous ex vivo expanded ASC injected into the breast tissue or face, both for cosmetic use, will significantly improve the results of…
- Trial name
- NCT03258164
- Testing
- ASC enriched lipofilling, Standard Lipofilling
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stemform
Disfigurement of Face
Self-Face Recognition After Face Transplantation
The purpose of the proposed study is to use functional magnetic resonance imaging (fMRI) to investigate how a change in facial appearance is initially represented in brain circuits and then alters over time, as the new face…
- Trial name
- NCT03027141
- Testing
- Face recognition task
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Corneal Injuries, Corneal Burns
Stem Cells Therapy for Corneal Blindness
This is a investigative initiated, comparative pilot clinical trial to ascertain the safety of application of ex-vivo cultivated limbal stem cells in human eyes for treating different superficial corneal pathologies.
- Conditions
- Corneal Injuries, Corneal Burns, Corneal Scars and Opacities
- Trial name
- ExCell (NCT02948023)
- Testing
- Ex-vivo cultivated limbal stem cell pool
- Where
- India
- Volunteers
- 100 people
- Sponsor
- L.V. Prasad Eye Institute
Facial Vascularized Composite Allotransplantation, Functional Recovery
Facial Vascularized Composite Allotransplantation: A Study Evaluating Safety, Functional Outcomes, and Patient-Reported Psychosocial Outcomes
The primary objective of this study is to evaluate the 5-year (60-month) allograft survival rate of facial vascularized composite allotransplantation performed under the standardized CONSORT clinical protocol.
- Trial name
- NCT07810764
- Testing
- Facial Vascularized Composite Allotransplantation (VCA)
- Where
- 9 sites in United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Facial Injuries, Traumatic Wounds and Injuries
Human Craniomaxillofacial Allotransplantation
Background: The human face is critically important for breathing, eating, seeing, and speaking/ communicating, but its most important job may be to look like a human face.
- Conditions
- Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects
- Trial name
- NCT01889381
- Testing
- Bone marrow cell-based therapy & 1-drug immunosuppression.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Injury of Facial Nerve, Unspecified Side, Initial Encounter
Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm
Main purpose：In the face of listening to nerve injury at early stage, utilizing autologous adipose stem cell transplantation in the treatment of makes the acceptance micro vascular decompression hemifacial spasm patients to nerve…
- Trial name
- NCT02853942
- Testing
- Autologous adipose stem cell therapy, Mecobalamin
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Facial Injuries
Craniomaxillofacial Allotransplantation
The purpose of this study is to perform face transplants on people who have suffered severe facial trauma with tissue and functional loss; and evaluate the acceptance and function of the transplanted tissue.
- Trial name
- NCT02158793
- Testing
- Craniomaxillofacial allotransplantation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Transplantation: Facial Transplantation
Human Composite Facial Allotransplantation
Allotransplantation of maxillofacial of subject with severe facial deformities due to traumatic events.
- Trial name
- NCT05117190
- Testing
- Facial Allotransplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Methodist Health System
Pharmaceutical Preparations
Human Partial Facial Allotransplantation
Progress in composite tissue allotransplantation provides a new remedy for severely disfigured patients. We plan to carry out allograft composite tissue transplantation after a careful systemic preparation.
- Trial name
- NCT00663988
- Testing
- human transplantation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Xijing Hospital