Clinical trials: Failure, Respiratory
Respiratory Failure, Anxiety
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant.
- Conditions
- Respiratory Failure, Anxiety, Critical Illness
- Trial name
- SMARA (NCT06341972)
- Testing
- Cognitive behavioral therapy based self-management for anxiety
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity, Respiratory Failure
Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient
The decision to extubate a patient after acute respiratory failure is based on clinical observation and measurement of pulmonary mechanics. Current extubation criteria(tidal volume, respiratory frequency...) lack of specificity.
- Conditions
- Obesity, Respiratory Failure, PSV 7cmH2O PEEP 7cmH2O, PSV 7 cmH2O PEEP 0 cmH20
- Trial name
- NCT01616901
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Failure
Global Physiotherapy in ICU Patients With High Risk Extubation Failure
This study aims to compare care provided by physiotherapists, combining respiratory care and early rehabilitation in intensive care unit, with standard care on the rate of acute respiratory failure within 7 days after extubation…
- Trial name
- KINEXTUB (NCT05423301)
- Testing
- Experimental, Control
- Where
- France
- Volunteers
- 245 people
- Sponsor
- University Hospital, Bordeaux
Pain
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
The purpose of this study is to determine if intrathecal hydromorphone will relieve pain as well as intrathecal morphine after cesarean delivery, with fewer side effects.
- Trial name
- NCT01866254
- Testing
- Hydromorphone, Morphine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Shih, MD
Hypertensive Urgency
Effect of Pursed-Lip Breathing on Blood Pressure and Heart Rate
Hypertensive urgency (HT urgency) is an alarm sign of uncontrolled hypertension. It can be aggravated by nonadherent to medication and psychosocial stress.
- Trial name
- NCT04572672
- Testing
- Non-pharmacologic treatment; Pursed-Lip Breathing Combined with Number Counting
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- Khon Kaen University
Mask Ventilation, Airway Obstruction Upper
The Articulated Oral Airway as an Aid to Mask Ventilation
The Articulating Oral Airway (AOA) is a novel oral airway which actively displaces the tongue, allowing for a greater cross-sectional area for mask ventilation.
- Conditions
- Mask Ventilation, Airway Obstruction Upper, Airway Management
- Trial name
- NCT03144089
- Testing
- Articulated Oral Airway, Guedel oral airway (active comparator)
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ron Abrons
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Prognostic Value of Estimated Plasma Volume in Pulmonary Hypertension
Assessment of the prognostic value of the estimation of plasma volume or its variation in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) after acute right heart…
- Conditions
- Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Acute Right Heart Failure
- Trial name
- NCT05861479
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Respiratory Failure
Benefit of Sleep Quality Monitoring by EEG in ICU
The goal of this observational study is to learn about the benefit of monitoring sleep quality using EEG in patients hospitalized in critical care unit for acute respiratory failure.
- Trial name
- REVASOM (NCT07522450)
- Testing
- EEG monitoring
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Rouen
Heart Failure, Congenital Heart Disease
Impact of a Structural Phonation Training on Respiratory Muscle Function in Patients With Structural Heart Disease
Most patients with complex congenital heart disease and cardiomyopathy from acquired heart disease have reduced exercise capacity. Exercise capacity is associated with respiratory muscle strength and function.
- Trial name
- NCT03297918
- Testing
- Respiratory muscle training
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Non Small Cell Lung Cancer (NSCLC)
Study of SPI-1620 in Combination With Docetaxel Versus Docetaxel Alone for Patients With Non Small-cell Lung Cancer (NSCLC)
The purpose of this study is to estimate and compare the objective response rate of SPI-1620 administered in combination with docetaxel in patients with NSCLC and to determine the safety of SPI-1620 when administered in…
- Trial name
- NCT01741155
- Testing
- SPI-1620, Docetaxel
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Healthy Volunteers, Heart Failure
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict…
- Conditions
- Healthy Volunteers, Heart Failure, Aortic Stenosis, Ischemic Heart Disease
- Trial name
- NCT00830726
- Testing
- Pharmacologic and mechanical heart failure treatment, Aortic valve replacement, Revascularisation in Acute Coronary Syndrome
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
COPD Exacerbation, Hypercapnia
Comfort of Patients Under Non Invasive Ventilation According to the Mask
A sub-nasal mask with a skirt that fits the nostrils and with a dedicated port for the nasogastric tube has recently been introduced. This interface has never been compared to nasal-oral masks.
- Conditions
- COPD Exacerbation, Hypercapnia, Hypoventilation Obesity Syndrome, Acute Respiratory Failure
- Trial name
- ComPaNIV (NCT06212180)
- Testing
- mask
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure
Prediction of Response to Recruitment Maneuvers in Patients With Acute Respiratory Failure
The study will explore the possibility to predict potential for recruitment in acute hypoxemic respiratory failure patients by electrical impedance tomography (EIT) Swisstom BB2 (Swisstom, Landquart, Switzerland) during stepwise…
- Trial name
- NCT02907840
- Testing
- Swisstom BB2
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Università degli Studi di Ferrara
Heart Failure, Chronic Obstructive Lung Disease
Primary Care Management/Action Plans for Advanced Chronic Diseases
Patients living with advanced chronic diseases (ACD), such as congestive heart failure (CHF) and chronic obstructive lung disease (COPD) present substantial care and economic challenges for the health care system due to frequent…
- Trial name
- NCT00202150
- Testing
- Application of a management action plan
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- Queen's University
Covid19
Effect of Prone Positioning Combined With High Flow Oxygen Therapy on Oxygenation During Acute Respiratory Failure Due to COVID-19
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients with AHRF, the need for invasive mechanical ventilation is associated with high mortality.
- Trial name
- DeCOPO (NCT04543760)
- Testing
- Prone position, Supine position
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Ventilatory Depression, Postoperative Respiratory Failure
Hyperoxia on Ventilation During Recovery From General Anesthesia
In this preliminary, crossover investigation the investigators will examine the effect of oxygen supplementation on the recovery of breathing in the immediate post-anesthesia period.
- Trial name
- NCT05922020
- Testing
- Oxygen gas
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Chronic Respiratory Failure
Effects of Long-term Dry and Humidified Low-flow Oxygen Via Nasal Cannula
During normal breathing, the upper and lower airways performs the priming of inspired gas: humidification, heating and filtering from nose to the bronchios for adequate gas exchange occurs in the lungs.
- Trial name
- NCT02515786
- Testing
- oxygen humidification
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo
Respiratory Failure
Noninvasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure…
- Trial name
- VHYPER (NCT01047852)
- Testing
- Noninvasive ventilation
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study
This single-arm, retrospective study aims to evaluate the safety and efficacy of subcutaneous treprostinil as a bridge therapy for lung transplantation in patients with severe pulmonary hypertension (PH).
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Chronic Lung Disease-Associated Pulmonary Hypertension, Lung Transplantation
- Trial name
- NCT06605326
- Testing
- Subcutaneous Treprostinil
- Volunteers
- 46 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Copd, Chronic Hypoxemic Respiratory Failure
Different Modalities of Exercise Training in COPD With Chronic Respiratory Failure (CRF)
Advanced Chronic Obstructive Pulmonary Disease (COPD) is a condition with a negative prognosis that causes symptoms such as wheezing and fatigue that dramatically reduce the quality of life of the person with the disease.
- Trial name
- NCT04201548
- Testing
- Endurance Training, Long High Intensity Interval Training, Short High Intensity Interval Training
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA