Clinical trials: Failure to Thrive
Idiopathic Short Stature, Failure to Thrive
Ghrelin Levels in Children With Poor Growth
The investigators hypothesize that low serum ghrelin levels may characterize a group of patients with poor weight gain and/or linear growth who do not have any other identified cause for growth failure.
- Trial name
- NCT01070173
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Tripler Army Medical Center
Complementary Feeding, Linear Programming
Optimized Complementary Feeding With or Without Home Fortification Prevents Decrease of Micronutrient and Growth
Malnourished among under-five children characterized by growth faltering is a public health concern in Indonesia. It requires serious action from the governments because of the prevalence of underweight, stunting, and wasting are…
- Conditions
- Complementary Feeding, Linear Programming, Nutritional Status, Micronutrient Deficiency
- Trial name
- NCT03891589
- Testing
- Nutritional education program, Home fortification (Taburia)
- Where
- Indonesia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Udayana University
Noonan Syndrome
Research Study Using Recombinant Human Insulin-Like Growth Factor-1/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 for Children With Noonan Syndrome
The trial will investigate the treatment of growth failure in children with Noonan syndrome. Abnormalities in the growth hormone (GH) - insulin-like growth factor-I (IGF-I) axis resulting in low IGF-I levels have been suggested…
- Trial name
- NCT00351221
- Testing
- rhIGF-1/rhIGFBP-3
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Insmed Incorporated
Failure to Thrive
Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome
This clinical trial will compare the mean first year height velocity of somatropin-treated prepubertal patients with SHOX deficiency with the height velocity of a control group of untreated prepubertal patients with SHOX…
- Trial name
- NCT00190658
- Testing
- Somatropin (rDNA origin) for injection
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Eli Lilly and Company
Lysosomal Acid Lipase Deficiency, Wolman Disease
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency
This was an open-label, repeat-dose, intra-participant dose-escalation study of SBC-102 (sebelipase alfa) in children with growth failure due to lysosomal acid lipase (LAL) Deficiency.
- Trial name
- NCT01371825
- Testing
- Sebelipase alfa (SBC-102)
- Where
- 7 sites in United States, Egypt and 3 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
HIV Infections
A Study of Megestrol Acetate in HIV-Infected Children
The purpose of this study is to see if megestrol acetate is safe and effective in treating HIV-infected children with failure to thrive (FTT).
- Trial name
- NCT00002182
- Testing
- Megestrol acetate
- Where
- Puerto Rico
- Volunteers
- 25 people
- Sponsor
- Gamma Project - ACTU
Turner Syndrome, Renal Insufficiency, Chronic
Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq
The main purpose of this study is to establish an optimal monitoring regimen in NutropinAq treated children, using newly developed capillary blood spot IGF-1 measurement technology.
- Conditions
- Turner Syndrome, Renal Insufficiency, Chronic, Pituitary Diseases, Dwarfism
- Trial name
- OPTIMA (NCT00234533)
- Testing
- Somatropin (rDNA origin)
- Where
- 45 sites in Belgium, Czechia and 12 more
- Volunteers
- 251 people
- Sponsor
- Ipsen
Growth Hormone Disorder, Pituitary Dwarfism
Somatropin (Norditropin) in Insulin-like Growth Factor (IGF) Deficient Children
This trial is conducted in the United States of America (USA). This is a 12 month study to determine if Norditropin is safe and effective in children with IGF deficiency.
- Trial name
- NCT00102817
- Testing
- somatropin
- Where
- 27 sites in United States
- Volunteers
- 149 people
- Sponsor
- Novo Nordisk A/S
Growth Hormone Deficiency
Sustained Release Formulation of Somatropin (rDNA Origin)for Injection
Annualised height velocity after 12/24 months treatment and HV SDS height velocity after 12/24 months treatment expressed as number of standard deviations difference from the mean population height velocity for the appropriate…
- Trial name
- NCT00600808
- Testing
- BPLG-003
- Volunteers
- 51 people
- Sponsor
- BioPartners GmbH
Growth Failure, Stunting
ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth
Haydom Global Health Research Center in north central Tanzania represents an important rural setting for performing high-quality medical research in sub-Saharan Africa.
- Conditions
- Growth Failure, Stunting, Malnutrition, Protein Malnutrition
- Trial name
- NCT04565314
- Testing
- Plumpy'Mum
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Growth Faltering, High Density Formula
The Efficacy of High Density Formula 1.5 kcal/ml or 1 kcal/ml On Catch Up Growth In Growth Faltering Children
High density calorie is an Oral Nutrition Supplement (ONS) which is a high calorie formula (High Density Formula) and suggested as nutritional therapy to assist children who are undernourished or undergoing growth faltering.
- Conditions
- Growth Faltering, High Density Formula, Catch Up Growth
- Trial name
- NCT06160765
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Universitas Airlangga
Cystic Fibrosis
Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis Patients
Many individuals with cystic fibrosis experience growth failure. The reasons are not clear, but inflammation of the gut in these patients seems to be one important reason.
- Trial name
- NCT02029521
- Testing
- Oral reduced l-glutathione
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Clark Bishop
Malnutrition
Prevention of Linear Growth Failure in Infants and Young Children With Lipid-based Nutrient Supplements (iLiNS-DOSE)
The use of lipid-based nutrients (LNS), such as Nutributter or fortified spread (FS), have been associated with improved growth and development outcomes among infants in Ghana and Malawi.
- Trial name
- iLiNS-DOSE (NCT00945698)
- Testing
- Lipid-based nutrient supplement, 10gM, Lipid-based nutrient supplement, 20gM, Lipid-based Nutrient Supplement, 20gNoM
- Where
- Malawi
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Tampere University
Growth Failure, Neurodevelopmental Disorder
High Energy Formula Feeding in Infants With Congenital Heart Disease
High energy formula more positively affect growth in infants with congenital heart disease compared to standard formula
- Trial name
- NCT01850784
- Testing
- High energy formula, Standard formula
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Stunting, Birth Weight
Aflatoxin Birth Cohort Study Nepal (AflaCohort)
The study focuses on the causal relationship between mycotoxin exposure (particularly aflatoxin B1), birth outcomes, and height for age among young children in Nepal.
- Conditions
- Stunting, Birth Weight, Birth Length, Height for Age
- Trial name
- AflaCohort (NCT03312049)
- Volunteers
- 1,675 people, healthy volunteers welcome
- Sponsor
- Tufts University
Chronic Diarrhea, Persistent Vomitting
Pediatric GI Endoscopy at Assiut University
1. To evaluate the diagnostic role, and outcomes of upper and lower gastrointestinal (GI) endoscopy in identifying gastrointestinal disorders among infants and pediatric patients attending Assiut University Children Hospital. 2.
- Conditions
- Chronic Diarrhea, Persistent Vomitting, Gastrointestinal Bleeding, Dysphagia
- Trial name
- NCT07239934
- Testing
- Gastrointestinal Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Maternal Malnutrition, Growth Failure
Women First: Preconception Maternal Nutrition
Multi-country three-arm, individually randomized, non-masked, controlled trial to ascertain the benefits of ensuring optimal maternal nutrition before conception and providing an evidence base for programmatic priority directed…
- Conditions
- Maternal Malnutrition, Growth Failure, Mortality, Morbidity
- Trial name
- WF (NCT01883193)
- Testing
- Comprehensive Maternal Nutrition Intervention
- Where
- 4 sites in Democratic Republic of the Congo, Guatemala and 2 more
- Volunteers
- 7,374 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infant Malnutrition, Malnutrition in Pregnancy
Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)
The use of lipid-based nutrients (LNS), such as Nutributter or fortified spread (FS), have been associated with improved growth and development outcomes among infants in Ghana and Malawi.
- Trial name
- iLiNS-DYAD-M (NCT01239693)
- Testing
- IFA, MMN, LNS
- Where
- Malawi
- Volunteers
- 1,391 people, healthy volunteers welcome
- Sponsor
- Tampere University
Failure to Thrive, Infection, Bacterial
High Calorie Formula Intervention on Weight, Length Increment, Total Lymphocyte Counts, TNF-alpha and IGF-1 in Failure to Thrive Children
High calorie formula (Oral Nutrition Supplement/ONS) are products used for oral nutrition support with the aim to increase the nutritional intake. they are a nutrition treatment option children with limited intake.
- Conditions
- Failure to Thrive, Infection, Bacterial, Growth Faltering
- Trial name
- NCT05333133
- Testing
- high calorie formula (oral nutritional supplement/ONS)
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Airlangga