Clinical trials: Fasciculations
Neurologic Symptoms
Fasciculations in Healthy Adults After Consumption of Caffeine: an Ultrasound Study
Fasciculations are clinically defined as spontaneous intermittent contractions of a portion of muscles. Depending on associated symptoms they may be a sign of lower motor neuron disorder.
- Trial name
- NCT05977920
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zurich Regional Health Center
Facet Joint Syndrome
Multifidus Muscle Twitch on the Prognosis of Lumbar Medial Branch RF
The investigators collected data and chart from the patients who were diagnosed facet joint syndrome and underwent lumbar RF medial branch neurotomy between January 2009 and June 2014.
- Trial name
- NCT02580383
- Testing
- Radiofrequency neurotomy of lumbar medial branch
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Severance Hospital
ICU Acquired Weakness
The Use of Musculoskeletal Ultrasound for the Detection of ICU-Acquired Weakness
Intensive Care Unit-Acquired Weakness (ICU-AW) is a clinical entity frequently encountered in critically ill patients that have both short term and long-term implications.
- Trial name
- NCT05048953
- Testing
- Muscle ultrasound measurements (the index test)
- Where
- Nepal
- Volunteers
- 114 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Fasciculation
Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia
The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.
- Trial name
- NCT02481193
- Testing
- Cisatracurium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yangzhou No.1 People's Hospital
Amyotrophic Lateral Sclerosis, Fasciculation
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS
The FLX-787-107 study will determine how well FLX-787-ODT works to reduce fasciculations in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03334786
- Testing
- FLX-787-ODT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Flex Pharma, Inc.
Fasciculation, Succinylcholine
Median Effective Dose of Cisatracurium for the Prevention of Fasciculation Caused by the Injection of Succinylcholine
Succinylcholine is currently the only depolarizing neuromuscular blocker widely used in anesthesia induction and is the drug of choice for rapid sequential anesthesia induction.
- Trial name
- NCT05760976
- Testing
- Cisatracurium
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Intubating Conditions, Fasciculations
Muscle Relaxation for Short Procedures
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex.
- Conditions
- Intubating Conditions, Fasciculations, Postoperative Myalgia, Patient Satisfaction
- Trial name
- NCT01902641
- Testing
- Succinylcholine, Rocuronium/Sugammadex, Rocuronium
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Motor Neuron Disease
Surface EMG and Ultrasound in MND
Patients with motor neurone disease typically experience relentless motor decline and die within three years of symptom onset from respiratory muscle weakness.
- Trial name
- NCT05314348
- Testing
- High-density surface EMG, Ultrasound
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Low Back Pain
Assessment of the Evolution of Lumbar Spine Movement Fluidity Using Xsens Inertial Sensors in Subjects With Chronic Low Back Pain Before and After Rehabilitation
Low back pain, defined as pain located between the thoracolumbar junction and the lower gluteal fold, becomes chronic in 8% of patients.
- Trial name
- Xmouv (NCT07327554)
- Testing
- X-sens sensor
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Motor Neuron Disease, Benign Fasciculation-Cramp Syndrome
Serial Fasciculation Measurements in Motor Neurone Disease
Patients with motor neurone disease (MND) typically experience relentless motor decline and die within three years of symptom onset from respiratory muscle weakness.
- Trial name
- NCT03809845
- Testing
- High-density surface electromyography
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Fasciculations
Effects of Cisatracurium on Sccinylcholine-induced Fasciculations
To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.
- Trial name
- NCT02502032
- Testing
- Cisatracurium
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Zhuan Zhang
Amyotrophic Lateral Sclerosis
Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurological disease. Nonspecific symptoms lead to a delay in the diagnosis, only confirmed by the electrophysiologic study. Objectives. 1.
- Trial name
- ALS (NCT02507713)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Myalgia
The Effect of Pretreatment With Roc on Succinylcholine Myalgias
Succinylcholine is a medication (depolarizing muscle relaxant) that is used as part of an anesthetic (going to sleep for surgery). This medication can cause significant muscle soreness.
- Trial name
- NCT04581395
- Testing
- non-pretreated Succinylcholine, succinylcholine 1 minute after rocuronium pretreatment, succinylcholine 2 minutes following rocuronium pretreatment
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Amyotrophic Lateral Sclerosis, Fasciculation
Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALS
The FLX-787-106 study will determine how well FLX-787-ODT works to reduce fasciculations in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03338114
- Testing
- FLX-787-ODT (orally disintigrating tablet)
- Where
- United States
- Sponsor
- Flex Pharma, Inc.
Cervical Facet Joint Pain, Chronic Pain
Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
The investigators aim to determine whether cervical paravertebral muscle twitching during motor testing as part of performing cervical RFAs is associated with a greater likelihood of treatment success, and greater magnitude or…
- Conditions
- Cervical Facet Joint Pain, Chronic Pain, Neck Pain
- Trial name
- NCT05450679
- Testing
- Cervical Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Johns Hopkins University