Clinical trials: Fasting Mimicking Diet
Overweight, Risk Behavior
Fasting-mimicking Diet and Longevity Diet, Body Composition and Aging
This study was designed as a large, randomized, controlled clinical trial in a heterogeneous population and is aimed at assessing as a primary objective whether the fasting-mimicking diet alone or in combination with the…
- Conditions
- Overweight, Risk Behavior, Obesity
- Trial name
- NCT05698654
- Testing
- Fasting-mimicking diet (FMD), Longevity Diet (LD) + Fasting-mimicking Diet (FMD)
- Where
- Italy
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Overweight, Obesity
Longevity Diet and the Fasting-mimicking Diet
This retrospective clinical study examines the impact of the longevity diet and fasting-mimicking diet (FMD), either alone or combined, on body composition and health indicators.
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Autoimmune Diseases
- Trial name
- NCT07065955
- Testing
- Longevity diet alone or in combination with fasting mimicking diet
- Where
- Italy
- Volunteers
- 365 people
- Sponsor
- Fondazione Valter Longo
Breast Cancer
FMD and Neoadjuvant Chemo-immunotherapy in TNBC
The primary objective of this study is to investigate the efficacy and safety of a fasting-mimicking diet (FMD) intervention combined with standard neoadjuvant chemoimmunotherapy in early-stage or locally advanced triple-negative…
- Trial name
- FACT-TN (NCT07378306)
- Testing
- Fasting-mimicking diet, Chemotherapy, Toripalimab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Fatigue; Muscle, Heart, Fasting
Effects of Fasting-Mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance
The aim of the study is to test a Fasting Mimicking Diet (FMD) for its efficacy on improving muscular resistance and endurance. The investigators will perform a randomized clinical trial to test the efficacy of the FMD on…
- Conditions
- Fatigue; Muscle, Heart, Fasting, Diet, Healthy, Fatigue, Mental
- Trial name
- FMD_Exercise (NCT04476615)
- Testing
- Fasting-Mimicking Diet (ProLon®)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Prostate Cancer, Metabolic Syndrome
Fasting Mimicking Diet in Prostate Cancer and Metabolic Syndrome
This is a prospective observational cohort study of patients with prostate cancer who have a metabolic syndrome. The study aims to evaluate the role of intermittent fasting (fasting mimicking diet) in these patients.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Intermittent Fasting
- Trial name
- NCT04292041
- Testing
- Fasting mimicking diet
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Galway Clinic
Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer
This phase Ib trial tests the safety, side effects, and effectiveness of botensilimab, and balstilimab in combination with a fasting mimicking diet and high dose vitamin C in treating patients with KRAS-mutant metastatic…
- Trial name
- NCT06336902
- Testing
- Balstilimab, Biospecimen Collection, Botensilimab
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Southern California
Non-small Cell Lung Cancer
Fasting-mimicking Diet With Chemo-immunotherapy in Non-small Cell Lung Cancer (NSCLC)
The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.
- Trial name
- NCT03700437
- Testing
- Fasting-Mimicking Diet
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Fasting, Diet, Healthy
Therapeutic Fasting and Immune Aging
Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire.
- Trial name
- JÛVENILE (NCT05857241)
- Testing
- Fasting mimicking diet (FMD)
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Immunosenescence
Fasting-mimicking Diet and Immunosenescence
The objective of this study is to test a Fasting-Mimicking Diet (FMD) for its efficacy on improving immune response to flu vaccination in an older adult population (50-75 years of age).
- Trial name
- NCT02554188
- Testing
- Seasonal influenza (flu) vaccine, Diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Diet, Autophagy
Fasting Mimicking Diet and Autophagy
This study aims to evaluates autophagy in circulating white blood cells from generally healthy human volunteers exposed to fasting mimicking diet (FMD), a 5-day dietary regimen.
- Trial name
- NCT06115551
- Testing
- Fasting Mimicking Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- L-Nutra Inc
Periodontitis
The Application of a Fasting- Mimicking Diet in Periodontitis: A Feasibility Study
The aim of the present study is to test if a fasting mimicking diet (FMD) can influence the systemic and periodontal response following non-surgical periodontal therapy.
- Trial name
- NCT05684627
- Testing
- Fast mimicking diet group, Normal diet group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Stage IV NSCLC, NSCLC
Evaluating a Fasting-mimicking Diet in Combination With Immunotherapy in Patients With Non-small Cell Lung Cancer
The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.
- Conditions
- Stage IV NSCLC, NSCLC, Immunotherapy, Fasting Mimicking Diet
- Trial name
- Stage IV NSCLC (NCT06671613)
- Testing
- FMD, Regular Diet Plus FMD
- Where
- 4 sites in United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Ovarian Cancer, Chemotherapeutic Toxicity
Fasting Mimicking Diet (FMD) in Conjunction With Chemotherapy in Advanced Ovarian Cancer
Rates of grade 3-4 toxicity with carboplatin and paclitaxel chemotherapy range 26-84%. Interventions to reduce toxicity are needed. Short term fasting protects against toxic effects of chemotherapy without decreasing efficacy.
- Trial name
- NCT05921149
- Testing
- Fasting Mimicking Diet (Xentigen by L'Nutra), Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Endeavor Health
Breast Cancer
Fasting-mimicking Diet Intervention on Side Effects of Aromatase Inhibitors Treatment in Patients With Breast Cancer
The primary endpoint of this study is to determine whether cycles of short term FMD exposure to a fasting-mimicking diet is effective in reducing total cholesterol levels.
- Trial name
- NCT06610565
- Testing
- FASTING-MIMICKING DIET PROGRAM
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- European Institute of Oncology
Cerebral Blood Flow, APOE 4
A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE)
The study aims to evaluate the safety, feasibility, and preliminary efficacy of the fasting-mimicking diet (FMD) or low-dose daily rapamycin treatment relative to a matched placebo control group when administered over 8 weeks in…
- Trial name
- NCT06682767
- Testing
- FMD1 (LNT22-017-1), Rapamycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Inflammatory Bowel Diseases, Crohn Disease
Fasting-mimicking Diet in Treatment of Depressive Symptoms in IBD
Inflammatory bowel disease (IBD) is a chronic illness characterized by inflammation of the intestine. Many individuals with IBD suffer from depressive symptoms and anxiety which can lead to a decreased quality of life, poor…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT05382897
- Testing
- Plant-based fasting-mimicking diet
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Coronary Artery Disease
Evaluation of a Fasting Mimicking Diet
Randomized, open-label, 7-month trial in eighty (80) adult subjects. Forty (40) subjects will be randomized to the intervention FMD arm with a 5 day meal program every month for four (4) months.
- Trial name
- NCT04150159
- Testing
- FMD Arm
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hypertension Institute, Nashville
Cancer, Breast Cancer
Fasting-mimicking Diet in Patients Undergoing Active Cancer Treatment
This is a pilot, single arm prospective trial assessing feasibility, safety and effects on patient nutritional status of a 5-day fasting-mimicking diet (FMD) in patients with different cancer types and concomitant anticancer…
- Conditions
- Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT03595540
- Testing
- Prolon
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Genova
Obesity
Fasting Mimicking Diet and Beige/Brown Adipose Tissue in Humans
Obesity today has become one of the main public health concerns. As a consequence, different strategies have arisen to fight weight gain.
- Trial name
- NCT04385615
- Testing
- Fasting Mimicking Diet
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Fasting Mimicking Diet, Breast Cancer
DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer
Preclinical studies provide strong support for the concept that fasting evokes resistance to multiple forms of stress. Fasting reduces plasma levels of growth factors and modulates intracellular nutrient sensing systems, thereby…
- Conditions
- Fasting Mimicking Diet, Breast Cancer, Neoadjuvant Chemotherapy, Pathological Complete Response
- Trial name
- DIRECT (NCT02126449)
- Testing
- Fasting mimicking diet
- Where
- 15 sites in Netherlands
- Volunteers
- 131 people
- Sponsor
- Leiden University Medical Center