Clinical trials: Fat Sensitivity
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
Elevated Liver Fat Content and Insulin Resistance
Effect of resVida on Liver Fat Content
The purpose of this study is to investigate the effects of the antioxidant "resveratrol" on liver fat content, body-composition and insulin sensitivity Resveratrol is found in grape skin, wine, peanuts, and mulberries and is…
- Trial name
- resVida NAFL (NCT01635114)
- Testing
- resveratrol
- Where
- Germany
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Diabetes
Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity
Early research found that high levels of fat within muscle meant poorer control of blood sugar. However, more recent research has shown that athletes have similar levels of fat within muscle, but in contrast, they have very good…
- Trial name
- MISTY (NCT03065140)
- Testing
- Training or detraining
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Obesity
Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity
Obesity and metabolic disease result when energy intake consistently exceeds energy expenditure. One appealing new target for treatment is the activation of brown adipose tissue (BAT), an organ recently found to be functional in…
- Trial name
- NCT02524184
- Testing
- sildenafil
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Type 2 Diabetes, Inflammation
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease.
- Conditions
- Type 2 Diabetes, Inflammation, Insulin Sensitivity/Resistance, Fatty Acids, Omega-3
- Trial name
- NCT04485871
- Testing
- Omega-3 fatty acids
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Cliniques de Montreal
Insulin Sensitivity
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity
The development of type 2 diabetes is based on a combination of insulin resistance and beta cell dysfunction. In the last years, elevated FFA were recognized as a key players in the pathogenesis of insulin resistance and type 2…
- Trial name
- FLAME (NCT01736202)
- Testing
- fat orally
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Insulin Resistance, Type 2 Diabetes
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity.
- Conditions
- Insulin Resistance, Type 2 Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT03863431
- Testing
- High-fat diet, High-carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Lipid Metabolism
Physiologic Plasticity of Intramyocardial Lipid Storage
The main goal of the present study was to provide a technical basis for future studies assessing the role of cardiac lipids. More specifically, non-invasive MR-Spectroscopy (MRS) techniques will be used in this study to: 1.
- Trial name
- NCT01921075
- Testing
- normal dietary behavior, Magnetic resonance spectroscopy
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obesity
Exercise Training and Fitness in Severe Obesity
Obesity is commonly associated with insulin resistance and hyperinsulinemia, which seem to be linked with an impaired ability to oxidize lipids, particularly in class III obese individuals [Body Mass Index (BMI): > 40 kg*m-2].
- Trial name
- INTFMOBE (NCT02254200)
- Testing
- Fatmax group, HIIT group
- Where
- Italy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity
Egg Diet to Improve Metabolic Health and Function
The purpose of this study is to determine the effects of change in diet quality (carbohydrate restriction versus fat restriction) on body composition, fat distribution, cardiometabolic risk factors, physical function, and quality…
- Trial name
- NCT02760641
- Testing
- Egg-based diet (EBD), Carbohydrate-based diet (CBD)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity
Prevention of Obesity in Women Via Estradiol Regulation
The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.
- Trial name
- POWER (NCT00687739)
- Testing
- leuprolide acetate, Estradiol Transdermal, progressive resistance exercise training
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Insulin Sensitivity, Metabolism Disorder
Insulin Sensitivity, Glucose - and Fat Metabolism in Patients With Psoriasis
The pathophysiological mechanisms explaining the association between psoriasis and type 2 diabetes are largely unknown but it has been hypothesized that systemic inflammation found in both psoriasis and type 2 diabetes might play…
- Trial name
- NCT02978001
- Testing
- Stabile Isotope tracers
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2, Cardiovascular Disease
Moderate Alcohol Consumption, Fat and Carbohydrate Metabolism and Insulin Sensitivity
Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption.
- Trial name
- NCT00364767
- Testing
- A, B
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- TNO
Metabolic Health, Insulin Sensitivity/Resistance
Defining the Human Insulin Resistance Molecular Network; SIGNATURE
The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it.
- Trial name
- SIGNATURE (NCT07255807)
- Testing
- Physical Inactivity, Hypercaloric High-Fat Diet
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Appetitive Behavior, Individual Difference
The Influence of Fat Perception on Satiety From Consumption of Reduced Fat Snacks
The present study aims to investigate the effect of fat level and fat type of a snack on self-reported satiety and associated biomarkers. The relevant individual differences will also be investigated.
- Conditions
- Appetitive Behavior, Individual Difference, Food Sensitivity, Food Preferences
- Trial name
- NCT03585920
- Testing
- Expanded Corn Snack
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Insulin Sensitivity
Effect of Acute Bout of Exercise on Levels of PAHSA
Exercise represents an important tool in the prevention and treatment of metabolic disorders associated with obesity and aging, such as type 2 diabetes and cardiovascular disease.
- Trial name
- ETAPA (NCT05572905)
- Testing
- Exercise, Fasting control
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lenka Rossmeislova
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Low-Calorie Diet, Diet, High-Protein
The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases.
- Conditions
- Low-Calorie Diet, Diet, High-Protein, Obesity; Pituitary, Weight Cycling
- Trial name
- NCT03374150
- Testing
- diet counseling
- Where
- 2 sites in Indonesia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Insulin Resistance, Type 2 Diabetes
Dietary Protein and Insulin Sensitivity Study
The overall objective of the Dietary Protein and Insulin Sensitivity Study is to test the hypothesis that increased protein in a diet with reduced carbohydrate (35% energy) can ameliorate insulin resistance in the absence of…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- NCT00508937
- Testing
- Diet
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Insulin Resistance
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity
High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance.
- Trial name
- NCT05017675
- Testing
- High fructose diet, High saturated fat diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center