Clinical trials: Fatigability
HIV, HIV Infections
Skeletal Muscle Energetics and Fatiguability in Older Individuals
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
- Trial name
- NCT04142047
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sclerosis, Multiple
Can Fatigability Neuromuscular Explain Chronic Fatigue in People With Multiple Sclerosis?
Chronic fatigue is the most common and debilitating symptom in multiple sclerosis patients. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.
- Trial name
- FatSEP (NCT03983720)
- Testing
- Evaluation of degree chronic fatigue., Questionnaires, Blood sample
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ankle Sprain, Ankle Instability
Auto-regulated Blood Flow Restriction in Athletes With Recurrent Ankle Sprain
Ankle injuries, especially lateral ankle sprains, are prevalent in physically active individuals. Blood Flow Restriction Training (BFRT) has emerged as a promising method, employing partial arterial occlusion and full venous…
- Trial name
- NCT06962943
- Testing
- Auto-regulated Blood Flow Restriction Training, Non-regulated Blood Flow Restriction Training, Control group
- Where
- United Arab Emirates
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Prince Sattam Bin Abdulaziz University
Fatigue
Impact of Transcranial Direct Current Stimulation on Fatigability and Fatigue Induced by a Selective Attention Task
This research project is focusing on changes in mental fatigue due to transcranial direct current stimulation (tDCS) in healthy individuals.
- Trial name
- NCT02840214
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Aging, Fatigue
Neuromodulation and Fatigue
In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation.
- Trial name
- NCT05487131
- Testing
- electrical stimulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cognitive Fatigue
Immersive VR Environments to Induce and Evaluate Cognitive Fatigability
Background: Immersive virtual reality (VR) technology is used by researchers to measure how people respond to complex stimuli in a controlled environment.
- Trial name
- NCT04883359
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Healthy
Impact of Transcranial Direct Current Stimulation Intensity on Leg Muscle Fatigability in Healthy Adults
Transcranial direct current stimulation (tDCS) is a painless,non-invasive means of increasing brain excitability. It has been used for several years and in many populations to improve physical and psychological outcomes.
- Trial name
- NCT04321304
- Testing
- Transcranial direct current stimulation at 2 mA, Transcranial direct current stimulation at 4 mA
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Fatigue
Fatigability and Cognitive Demand With Aging
This study will determine the influence of a cognitive task performed during fatiguing contractions.
- Trial name
- NCT05121272
- Testing
- cognitive task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Aging, Muscle Fatigue
Impacts and Mechanisms of Age and Muscle Fatigue on Postural Control and Force Control
Muscle fatigue is one of the clinical symptoms in elderly people and demonstrates task dependency and muscle dependency. Muscle fatigue has been shown to negatively impact postural control, physical activity, and quality of life.
- Trial name
- NCT07405060
- Testing
- Age, Muscle fatigue
- Where
- 2 sites in Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Fatigue
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body…
- Trial name
- NCT01661595
- Testing
- Sildenafil, tadalafil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Multiple Sclerosis, Healthy
Walking Fatigability and Brain Activity in People With Multiple Sclerosis
Walking fatigability is a motor impairment happening in approximately 43.5% of people with multiple sclerosis (pwMS). Walking fatigability is defined as a decrease in 10% of distance walked, comparing the first minute with the…
- Trial name
- NCT06672484
- Where
- 3 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Electrical Stimulation
Influence of Electrode Positioning and Current Type on Fatigue, Force and Discomfort
Introduction: Neuromuscular electrical stimulation (NMES) has the purpose of generating muscle contractions to minimize muscular atrophy and to improve neuromuscular performance.
- Trial name
- NCT04200677
- Testing
- Monophasic Current (100 Hz) with 1ms pulse width applied to the Tibial Nerve, Biphasic current (100 Hz) with pulse width 0.5ms applied to the Tibial Nerve, Biphasic current (100 Hz) with 1ms pulse width applied to the Tibial Nerve
- Where
- 2 sites in Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Muscle Spasticity, Paralysis; Cerebral
The Decline in Walking Performance in Adults With Cerebral Palsy - Influence of Performance Fatigability
Due to an early brain injury occurring in antenatal or postnatal, cerebral palsy (CP) causes alteration in motor function with posture and gait disorders.
- Trial name
- FAT-GAIT (NCT06163950)
- Testing
- Fatigability assessment
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adult, Fatigue
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals.
- Trial name
- NCT03800342
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- George Mason University
Aging
Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation
This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults
- Trial name
- NCT03619070
- Testing
- Resistance training, LL, Resistance training, HL, Resistance training, HVHL
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Healthy
4 mA tDCS, Estrogen, and Leg Muscle Fatigability
The majority of transcranial direct current stimulation (tDCS) studies have failed to consider sex as a modulating factor. This neglect may partly account for the high inter-subject variability bemoaned by many tDCS investigators…
- Trial name
- NCT04471805
- Testing
- Transcranial direct current stimulation 4 mA
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Chronic Kidney Disease Predialysis
Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease
The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease.
- Trial name
- NCT04397159
- Testing
- Combination Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aging
Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation
Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice increases NO bioavailability and improves…
- Trial name
- NCT05313490
- Testing
- Beetroot Juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marquette University