Clinical trials: Fatigue in Multiple Sclerosis
Multiple Sclerosis, Fatigue
MitoQ for Fatigue in Multiple Sclerosis (MS)
The purpose of this study is to determine whether MS patients who receive Oral mitoquinone (MitoQ) have less fatigue than those receiving a placebo.
- Trial name
- MitoQ (NCT04267926)
- Testing
- 20 mg MitoQ, 40mg of MitoQ
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Fatigue in Multiple Sclerosis
Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis
Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil…
- Trial name
- TRIUMPHANT-MS (NCT03185065)
- Testing
- Amantadine, Modafinil, Methylphenidate
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Johns Hopkins University
Progressive Multiple Sclerosis, Fatigue
A Study of Oxidative Pathways in MS Fatigue
This is a 4-week randomized, placebo-controlled, parallel group, double-blind, single center trial on effect of N-acetyl cysteine versus placebo on fatigue in patients with progressive MS defined by McDonald criteria.
- Trial name
- NCT02804594
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)
The purpose of the study was the evaluation of the effect of a treatment for highly-active relapsing multiple sclerosis (RMS). This was the extension study to CLARIFY MS (NCT03369665), to assess cognitive impairment and health…
- Trial name
- NCT04776213
- Testing
- Mavenclad®
- Where
- 60 sites in Austria, Czechia and 8 more
- Volunteers
- 280 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Multiple Sclerosis, Relapsing-Remitting
ACTH for Fatigue in Multiple Sclerosis Patients
This is a study of Acthar gel (ACTH) in patients with relapsing multiple sclerosis who are experiencing chronic fatigue.
- Trial name
- ACTH (NCT02315872)
- Testing
- ACTH
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Providence Health & Services
Fatigue, Overheating
Aspirin as a Pre-Treatment for Exercise in Multiple Sclerosis
Exercise has many benefits for people with multiple sclerosis (MS), such as improved physical symptoms, mood, fatigue, and cognition.
- Trial name
- NCT03051646
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Parkinson's Disease, Multiple Sclerosis
Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients
Fatigue is one of the most common and debilitating symptoms experienced in Parkinson's Disease (PD) and Multiple Sclerosis (MS).
- Trial name
- PDMSLac (NCT02184494)
- Testing
- pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Florida State University
Multiple Sclerosis, Fatigue
A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia
This study assesses the safety, tolerability, and efficacy of suvorexant in multiple sclerosis patients. Enrolled subjects will receive 2 weeks of treatment during treatment period 1 with either suvorexant or matching placebo…
- Conditions
- Multiple Sclerosis, Fatigue, Insomnia
- Trial name
- DREAM (NCT03110315)
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Theodore R. Brown, MD MPH
Multiple Sclerosis
Impact of Armodafinil on Neurocognition and Cognitive Fatigue in Multiple Sclerosis (MS)
The investigation will involve a double-blind, placebo controlled, cross-over study examining the efficacy of armodafinil in improving neurocognitive functioning and reducing cognitive fatigue in MS.
- Trial name
- NCT00981084
- Testing
- armodafinil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Missouri, Kansas City
Multiple Sclerosis, Fatigue
Dalfampridine for Imbalance in Multiple Sclerosis
Dalfampridine is a new medication that was FDA approved in 2010 to improve walking speed in people with Multiple Sclerosis (MS).
- Trial name
- NCT01444300
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Telehealth-Based Exercise Program to Treat Fatigue in MS
This is a clinical trial examining a brief motivational intervention to improve adherence to exercise among individuals with MS to improve fatigue.
- Trial name
- MS-FIT (NCT01198977)
- Testing
- Brief telephone-based counseling, Education counseling
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
MS Spinal Mobilisation Study
The objective of the study is to measure the effect of a spinal mobilisation intervention on para-spinal muscle tissue quality, functional balance measures, pain and fatigue in people with multiple sclerosis.
- Trial name
- NCT05090709
- Testing
- Spinal Mobilisation Intervention, General Massage
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Edinburgh Napier University
Fatigue in Multiple Sclerosis
Effect of Physical ACtivity in Fingolimod Treated patiEnts (PACE) With Relapsing-remitting Multiple Sclerosis
This study evaluated the effect of an individualized web-based physical training in fingolimod -treated patients.
- Trial name
- PACE (NCT01490840)
- Testing
- Physical exercise
- Where
- 32 sites in Germany
- Volunteers
- 178 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
A Randomized Trial of Two Formal Group Programs for Multiple Sclerosis
The purpose of this study is to compare two different educational programs for people with multiple sclerosis (MS), which is a common and often disabling disease of the central nervous system.
- Trial name
- NCT01918800
- Testing
- Fatigue: Take control, MS: Take Control
- Where
- 4 sites in United States
- Volunteers
- 282 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Can Transcranial Direct Current Stimulation Improve Ambulation and Fatigue Resistance in People With MS?
In this project the investigators will be using non-invasive brain stimulation on people with multiple sclerosis (PwMS) to improve leg muscle function. Two groups of participants will be recruited.
- Trial name
- NCT02987621
- Testing
- tDCS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Colorado State University
Multiple Sclerosis, Pain
Usability of the MeTime MS App
The Me Time MS Application was designed to enable self-administration of acupressure. Two forms of acupressure - either "relaxing" or "stimulating" protocols - are administered through the Me Time MS app.
- Conditions
- Multiple Sclerosis, Pain, Fatigue Symptom
- Trial name
- NCT07123272
- Testing
- Self-guided smartphone application for relaxing acupressure, Self-guided smartphone application for stimulating acupressure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Multiple Sclerosis, Internuclear Ophthalmoplegia
Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis
Primary fatigue represents a major cause of disability in patients with multiple sclerosis (MS), being reported in about 90% of cases.
- Conditions
- Multiple Sclerosis, Internuclear Ophthalmoplegia, Fatigue
- Trial name
- NCT02391961
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Relapsing-Remitting
Light Therapy as Treatment for Fatigue in Multiple Sclerosis
This prospective study will randomize 1:1 people living with multiple sclerosis-associated fatigue to one of two spectra of light therapy.
- Trial name
- NCT03060759
- Testing
- Light Therapy box
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis, Fatigue
Cubii for Exercise in People With MS
The goals of this observational study are to evaluate (1) the feasibility, usability, and satisfaction with the Cubii elliptical and (2) the preliminary efficacy of the Cubii elliptical for increasing activity (primary outcome)…
- Conditions
- Multiple Sclerosis, Fatigue, Activity, Motor, Quality of Life
- Trial name
- Cubii (NCT05826431)
- Testing
- Cubii elliptical
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Washington