Clinical trials: Fear Extinction
Stress Disorders, Posttraumatic
Veteran Stress and Learning Study
This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms…
- Trial name
- VSL (NCT00674570)
- Testing
- Hydrocortisone, D-Cycloserine
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Subjects
The Link Between Mental Imagery and the Reduction of Fear in Imaginal Extinction
Imaginal exposure is a widely used psychological treatment technique. Imaginal extinction is an experimental analogue of imaginal exposure, that allows the study of this treatment technique under controlled circumstances (Agren…
- Trial name
- NCT03989518
- Testing
- Fear acquisition, Imaginal extinction, Reinstatement
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Anorexia Nervosa
Estradiol and Fear Extinction in Anorexia Nervosa (AN)
The purpose of this study is to determine whether estrogen may help reduce fear of high calorie-density foods in weight-restored women with Anorexia Nervosa (AN).
- Trial name
- NCT02792153
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Posttraumatic Stress Disorder
Enhancing Exposure Therapy for Post-traumatic Stress Disorder
This study is investigating a new brief psychotherapy for post-traumatic stress disorder (PTSD) which, modifies an already proven psychotherapy for PTSD by adding two new components and modifying several others.
- Trial name
- NCT01574118
- Testing
- Revisiting the Trauma memories, Processing the trauma memories, Psychoeducation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy
Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction
Serotonin and oxytocin play a role in fear conditioning and fear extinction learning, psychological processes that are critically involved in psychiatric disorders such as posttraumatic stress disorder (PTSD).
- Trial name
- MFE (NCT03527316)
- Testing
- MDMA
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Fear, Anxiety
Social Support and Reduced Fear Acquisition
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the…
- Trial name
- NCT04564976
- Testing
- Social support image
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fear, Stress
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
Background: Researchers want to learn if people with alcohol dependence have more difficulty learning to feel calm, or learn to fear things more easily.
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02438969
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
PTSD
The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without…
- Trial name
- NCT06144203
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Oxytocin, Estrogen
Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin
The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT).
- Conditions
- Oxytocin, Estrogen, Fear Extinction, Emotion Processing
- Trial name
- ESMory (NCT04330677)
- Testing
- Oxytocin nasal spray, Estrogen Gel
- Where
- Germany
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Fear of Spiders
The Neural Mechanisms of Imaginal Extinction
Imaginal exposure is a widely used and effective psychological treatment technique in which patients are exposed to fearful stimuli and situations using mental imagery.
- Trial name
- NCT05168592
- Testing
- Threat conditioning, Imaginal extinction
- Where
- Sweden
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acrophobia
Single Session Virtual Reality Therapy in Acrophobia - and the Role of Respiration
In recent years, in the treatment of phobias, exposure therapy in virtual reality is becoming more and more popular as an alternative for in-vivo exposure.
- Trial name
- NCT03893214
- Testing
- virtual reality exposure for acrophobia, movie
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Fear, Fear; Examination, Phobic
Impact of Estrogen on Fear Extinction R61
The goal of this project is to examine how estrogen may influence the resting-state connectivity and the extinction-induced activation of the fear extinction network.
- Trial name
- NCT02673606
- Testing
- Estradiol 2Mg Tablet, Estradiol 4Mg Tablet
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Fear, Anxiety
Social Support and Enhanced Fear Extinction
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the…
- Trial name
- NCT04565041
- Testing
- Social Support
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stress Related Disorder, Anxiety
Modulation of Fear Extinction Processes Using Transcranial Electrical Stimulation
The aim of this study is to examine the effects of transcranial electrical stimulation on processes associated with fear extinction in healthy humans.
- Trial name
- NCT02723188
- Testing
- DC stimulation (1.5 milliampere, 20 minutes), AC stimulation (1.5 milliampere,1.5 Hertz frequency)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Anxiety Disorders
Transcranial Direct Current Stimulation and Fear Extinction
Psychiatric disorders characterized by pathological fear and anxiety are common and often disabling. Despite their limitations, exposure therapies are among the most efficacious treatments for these disorders.
- Trial name
- NCT03907917
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Thomas Adams