Clinical trials: Febrile
Pneumonia, Diarrhea
Testing the Effectiveness of a Modified Community Model in Improving Child Health Outcomes in Mashonaland East, Zimbabwe
This study modified and contextualized a community mobilization approach in a bid to find a solution to reduce the high incidence and prevalence of child morbidity and mortality in Zimbabwe.The developed model will be tested for…
- Conditions
- Pneumonia, Diarrhea, Malnutrition, Fever
- Trial name
- NCT03176914
- Testing
- prevention and management of childhood illnesses at community level, conventional community interventions
- Where
- Zimbabwe
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Rectal Cancer
Neoadjuvant Chemoradiation With 5-FU(or Capecitabine) and Oxaliplatin Combined With Hyperthermia in Rectal Cancer
This trial examines the feasibility, effectiveness and safety of a combination of radiotherapy (over a period of five weeks) and chemotherapy (with 5-FU or Capecitabine and Oxaliplatin) and 10 fractions of deep regional…
- Trial name
- HyRec (NCT01716949)
- Testing
- Radiotherapy, Hyperthermia, 5-Fluorouracil
- Where
- 6 sites in Germany
- Volunteers
- 59 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Enteric Fever, Acute Febrile Illness
Transcriptomic Responses for the Identification of Pathogens
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions.
- Conditions
- Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever
- Trial name
- TRiP (NCT04878549)
- Testing
- 5-gene transcription signature
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer
This phase II trial studies how well heated mitomycin and cisplatin during surgery work in treating patients with stomach or gastroesophageal cancer.
- Conditions
- Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis
- Trial name
- NCT02891447
- Testing
- Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Mitomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Febrile Neutropenia, Hematological Malignancy
Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
A multicenter open-label non-inferiority randomized clinical trial comparing the safety (non-inferiority) of short antibiotic treatment (72 hours) with an anti-pseudomonal carbapenem with regard to treatment failure in comparison…
- Trial name
- SHORT (NCT02149329)
- Testing
- Discontinuation of imipenem-cilastatin or meropenem
- Where
- 2 sites in Netherlands
- Volunteers
- 276 people
- Sponsor
- Amsterdam UMC, location VUmc
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Infectious Disease, Children, Only
Effect of Prebiotic Fructans to Reduce Number of Febrile Infections in Children
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on the reduction of the number of febrile infections diagnosed by the paediatrician in children.
- Conditions
- Infectious Disease, Children, Only, Diet Modification
- Trial name
- NCT03457688
- Testing
- prebiotic inulin-type fructans
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Fever
Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion.
- Trial name
- NCT02430272
- Testing
- Glycopyrrolate
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Inje University
Hemorrhagic Fever With Renal Syndrome
Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany
This is a treatment protocol using IND Ribavirin-there is no control group. Hemorrhagic Fever with Renal Syndrome (HFRS) is caused by a virus acquired by contact with chronically infected rodent hosts.
- Trial name
- HFRS (NCT00868946)
- Testing
- Virazole (Ribavirin)
- Where
- Germany
- Sponsor
- U.S. Army Medical Research and Development Command
Newborn; Hyperthermia
Randomised Controlled Trial on Using Active Warming to Prevent Newborn Hypothermia After Caesarean Delivery
Despite the enormous advantages that skin-to-skin contact (STSC) and Delaying Cord Clamping (DCC) bring, newborns can lose heat quickly if they are not thermally protected.
- Trial name
- NCT06532266
- Testing
- TechTrade Ready Heat Half Body Temperature Management Blankets, Control
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Colorectal Cancer Metastatic, Peritoneal Metastases From Colorectal Cancer
NeoRes Study - Preoperative Chemotherapy in Colorectal Peritoneal Disease Prior to Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Study Title: Neores Study - Evaluating Systemic Chemotherapy Efficacy in Colorectal Peritoneal Metastases Principal Investigator: Peter Cashin Akademiska sjukhuset / Uppsala universitet Background: Peritoneal metastases from…
- Trial name
- NEORES (NCT06903039)
- Where
- Sweden
- Volunteers
- 185 people
- Sponsor
- Uppsala University
Fever
Non-inferiority Trial of Conditional vs Universal Follow up for Children With Fever in Democratic Republic of Congo
Providers in integrated Community Case Management (iCCM) programs in low resource settings often see children without any danger signs, presenting with fever but not having pneumonia, malaria, or diarrhea.
- Trial name
- NCT02595827
- Testing
- Conditional Advice
- Where
- Democratic Republic of the Congo
- Volunteers
- 4,451 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy Adult, Healthy Adolescents
Evaluation of IXCHIQ® Vaccine Immunogenicity
The goal of this clinical trial is to evaluate the quality and duration of the immune response against chikungunya virus elicited by the IXCHIQ® vaccine in healthy adults and adolescents.
- Trial name
- IMUNO-CHIQ (NCT07846293)
- Testing
- IXCHIQ vaccine
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mauro Martins Teixeira
Dengue, Dengue Hemorrhagic Fever
Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America
Primary objectives: To describe the immune response to each dengue serotype before and after each vaccination with sanofi pasteur's CYD dengue vaccine.
- Conditions
- Dengue, Dengue Hemorrhagic Fever, Dengue Virus, Dengue Fever
- Trial name
- NCT00993447
- Testing
- CYD Dengue Vaccine, Tetanus Toxoid Reduced Diphtheria Toxoid Acellular Pertussis
- Where
- 4 sites in Colombia, Honduras and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Yellow Fever Vaccine, Yellow Fever
Yellow Fever Vaccine on Statin/ Non Statin Subjects
Since the 1st pandemic of the 21st century caused by SARS coronavirus, the world has experienced outbreaks of swine origin H1N1 influenza, Ebola and Zika viruses, which have all resulted in global health crises.
- Trial name
- NCT03116802
- Testing
- Stamaril (live attenuated yellow fever vaccine)
- Where
- Singapore
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Breast Cancer
Effectiveness of Reduced GCSF Dosing in Patients With a Low to Moderate Risk of Febrile Neutropenia
The study aims to confirm that a reduced dosage of GCSF is effective in preventing febrile neutropenia among patients with breast cancer, treated with chemotherapy and presenting with a low to moderate risk of developing febrile…
- Trial name
- PAPALDO (NCT01658956)
- Testing
- GCSF administration on days 8 and 12 after chemotherapy
- Where
- Belgium
- Volunteers
- 142 people
- Sponsor
- Jules Bordet Institute
Puerperal Infection, Fever
Diet and Lifestyle Intervention Study in Postpartum Women in China
Previous studies have shown "Doing the month", a traditional practice for postpartum women in China and other Asian countries, may be associated with higher prevalence of postpartum problems.
- Conditions
- Puerperal Infection, Fever, Constipation, Hemorrhoids
- Trial name
- NCT01039051
- Testing
- Diet and Lifestyle Intervention in Chinese Postpartum Women
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Acute Pyelonephritis
Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection
Hypothesis: Administration of corticoids (dexamethasone) together with the conventional antibiotherapy in the acute phase of a febrile urinary tract infection could reduce the risk of renal scarring after 6 months of the…
- Trial name
- DEXCAR-0212 (NCT02034851)
- Where
- 7 sites in Spain
- Volunteers
- 183 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Renal Stones
Standard Versus Mini Percutaneous Nephrolithotomy for Renal Stones
Renal stone disease is a common urological condition associated with significant morbidity. Percutaneous nephrolithotomy (PCNL) is the standard treatment for renal stones larger than 2 cm.
- Trial name
- NCT07464717
- Testing
- Mini Percutaneous Nephrolithotomy, Standard Percutaneous Nephrolithotomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital