Clinical trials: Fecal Incontinence and Constipation
Spinal Cord Injuries, Constipation
Neostigmine and Glycopyrrolate by Iontophoresis
To determine a lower effective dose of neostigmine to induce bowel evacuation by transcutaneous administration by iontophoresis.
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351995
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Refractory Constipation, Fecal Incontinence in Children
The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation
This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans…
- Trial name
- NCT07291661
- Testing
- High resolution anorectal manometry using a multiuse water perfused catheter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Constipation Aggravated, Fecal Incontinence With Fecal Urgency
A Comparison of Quality of Life Between MAlone Procedure and Percutaneaous Endoscopic Caecostomy in Patients With Antegrade Colonic Enema
Background: Antegrade colonic enema (ACE) is a second intent treatment of severe constipation and/or fecal incontinence following the failure of medical treatment.
- Trial name
- MAPEC (NCT05040139)
- Testing
- Malone Procedure, Percutaneous endoscopic caecostomy
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Nantes University Hospital
Constipation
Biofeedback for Dyssynergic Constipation
Constipation affects 4% of adults in the United States (U.S.). An estimated half of constipated patients are unable to relax pelvic floor muscles during defecation, a type of constipation called pelvic floor dyssynergia (PFD).
- Trial name
- NCT00127257
- Testing
- Biofeedback, Diazepam, Pelvic floor retraining
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pelvic Organ Prolapse, Constipation
Cohort Study of Bowel Function Following Robotic-assisted Laparoscopic Sacrocolpopexy
Compare changes in bowel function before, 6 months and one year after Robotic-assisted laparoscopic sacral colpopexy. Compare objective anatomic outcomes before, 6 months and one year after Robotic-assisted laparoscopic sacral…
- Conditions
- Pelvic Organ Prolapse, Constipation, Bowel Dysfunction, Irritable Bowel Syndrome
- Trial name
- NCT01618292
- Testing
- Robotic sacral colpopexy
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Atlantic Health System
Irritable Bowel Syndrome, Functional Dyspepsia
The Multi-disciplinary Treatment of Functional Gut Disorders Study
Randomised controlled trial comparing standard outpatient clinic treatment with multi-disciplinary clinic treatment for functional gastrointestinal disorders.
- Conditions
- Irritable Bowel Syndrome, Functional Dyspepsia, Constipation - Functional, Faecal Incontinence
- Trial name
- MANTRA (NCT03078634)
- Testing
- Multi-disciplinary clinic model, Standard outpatient care
- Where
- Australia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- St Vincent's Hospital Melbourne
Pelvic Floor Disorders, Obstetric Trauma
Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth
This is a single-center prospective cohort study sponsored by the University Hospitals Leuven (UZ). Women will undergo a pelvic floor ultrasound and will be asked to fill out a questionnaire at the time of their admission into…
- Conditions
- Pelvic Floor Disorders, Obstetric Trauma, Urinary Incontinence, Anal Incontinence
- Trial name
- DeliverUU (NCT05530681)
- Testing
- Questionnaire, Pelvic floor ultrasound
- Where
- Belgium
- Volunteers
- 320 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Constipation, Fecal Incontinence
Sierra High Definition Ano-Rectal Manometry
Hypotheses: High definition manometry (HDM) is safe and feasible in humans; HDM accurately characterizes anorectal anatomy and function in healthy humans; HDM provides comparable information regarding the structure and function…
- Trial name
- NCT01300884
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Augusta University
Multiple Sclerosis, Anorectal Disorders
Effect of Need to Void on Rectal Sensory Function in Multiple Sclerosis
Multiple sclerosis causes demyelinating lesions, which can induce multiple symptoms. Ano-rectal avec urinary disorders are frequent due to specific lesions in inhibitor/activator encephalic centers, or interruption on medullary…
- Conditions
- Multiple Sclerosis, Anorectal Disorders, Bladder Dysfunction
- Trial name
- NCT04057222
- Testing
- No intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Gérard Amarenco
Rectal Cancer, Fecal Incontinence and Constipation
Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome
Low Anterior Resection Syndrome (LARS) is a common complication after sphincter-preserving rectal cancer surgery and may negatively affect bowel function and quality of life.
- Conditions
- Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise
- Trial name
- NCT07732894
- Testing
- Exercise, guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Constipation, Fecal Incontinence
Treating Anorectal Dysfunction in MS
The investigators seek to test whether incorporating the scheduled dosing of a bisacodyl 10 mg rectal suppository every other day improves bowel-related symptoms in patients with multiple sclerosis.
- Conditions
- Constipation, Fecal Incontinence, Multiple Sclerosis
- Trial name
- NCT02609607
- Testing
- Bisacodyl
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David Levinthal
Faecal Incontinence, Constipation - Functional
Peristeen Light Explorative Clinical Investigation
The goal of this exploratory clinical investigation is to understand the clinical benefits of Peristeen Light in adult patients with faecal incontinence, chronic constipation and/or time-consuming bowel management procedures.
- Trial name
- NCT07126327
- Testing
- Peristeen Light - trans anal irrigation system
- Where
- 2 sites in Denmark, Italy
- Volunteers
- 60 people
- Sponsor
- Coloplast A/S
Constipation, Fecal Incontinence
Treatment of Fecal Incontinence and Chronic Constipation With Low-volume Irrigation
The aim of this study is to investigate the efficacy of low-volume irrigation on bowel function among patients with fecal incontinence and/or chronic constipation (of heterogenous origin).
- Trial name
- NCT05773742
- Testing
- Low-volume irrigation
- Where
- Denmark
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Constipation, Children
Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children
Pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum.
- Conditions
- Constipation, Children, Fecal Incontinence
- Trial name
- NCT02812823
- Testing
- High-resolution anorectal manometry
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Functional Constipation, Fecal Incontinence in Children
Effect of MiniGo As Add-on to Oral Laxatives for Children with Constipation and Fecal Incontinence
The goal of this clinical trial is to compare combination therapy with low volume trans anal irrigation (TAI) and oral laxatives to monotherapy with oral laxatives in children with functional constipation and fecal incontinence.
- Trial name
- NCT05570318
- Testing
- Polyethylene Glycols, Low volume trans anal irrigation
- Where
- 3 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Faecal Incontinence, Chronic Constipation
Outcome Research in Bowel Irrigation Techniques for the Treatment of Chronic Constipation and/or Faecal Incontinence
This clinical investigation is a post-market, exploratory, randomised, parallel, open-label investigation comparing two UKCA/CE-marked transanal irrigation products for the management of faecal incontinence and/or chronic…
- Trial name
- ORBIT-1 (NCT07473622)
- Testing
- Transanal irrigation
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Qufora A/S
Abdominal Pain, Deglutition Disorders
Evaluating the Impact of Automated Evaluation of Gastrointestinal Symptoms (AEGIS) on Clinical Outcomes
Healthcare delivery now mandates shorter visits with higher documentation requirements, undermining the patient-provider interaction.
- Conditions
- Abdominal Pain, Deglutition Disorders, Fecal Incontinence, Nausea
- Trial name
- AEGIS (NCT02530216)
- Testing
- AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Cedars-Sinai Medical Center
Constipation, Fecal Incontinence
Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury
The study aims to compare a newly developed system for transanal colonic irrigation (Peristeen Anal Irrigation) with a bowel management regime that does not include irrigation in a prospective, randomized trial in spinal cord…
- Conditions
- Constipation, Fecal Incontinence, Spinal Cord Injury
- Trial name
- NCT00286520
- Testing
- Transanal irrigation with Peristeen Anal Irrigation
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Massage
Massage With Senna-based Laxatives Versus Senna-based Laxatives in Managing Overflow Retentive Stool Incontinence
This study aimed to evaluate the effect of abdominal massage with senna-based laxative in managing overflow retentive stool incontinence in pediatrics.
- Trial name
- NCT04273295
- Testing
- Abdominal massage
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- South Valley University
Fecal Incontinence and Constipation
Sacral Nerve Stimulation for Anal Incontinence and Bowel Control
Multicenter European study to evaluate efficacy and safety of sacral nerve stimulation with InterStim Therapy to treat fecal incontinence or constipation
- Trial name
- MDT-301 (NCT00200005)
- Testing
- Type: Implantable neurostimulator; InterStim
- Where
- 9 sites in United States, Austria and 6 more
- Volunteers
- 140 people
- Sponsor
- MedtronicNeuro