Clinical trials: Fecal Microbiota
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
GVHD
Fecal Microbiota Transplant (FMT) Capsule for Improving the Efficacy of GI-aGVHD
This study aims to determine whether the fecal microbiota transplant (FMT) capsule improves the response rate of GI-aGVHD in patients with glucocorticoid-refractory acute graft vs.
- Trial name
- NCT05094765
- Testing
- FMT
- Volunteers
- 15 people
- Sponsor
- Shenzhen Xbiome Biotech Co., Ltd.
CARRIER STATE
Efficacy of a Probiotic or Fecal Microbiota Transplantation (FMT) on the Eradication of Rectal Multidrug-resistant Gram-negative Bacilli (MDR-GNB) Carriage (PROFTMDECOL)
The working hypothesis is that in patients who are rectal carriers of MDR-GNB (Multi drug-resistant gram negative bacilli), the rate and speed of eradication of the carrier status obtained with NAA regimens are insufficient and…
- Trial name
- PROFTMDECOL (NCT04431934)
- Testing
- PROBIOTIC, FMT REGIMEN
- Where
- Spain
- Volunteers
- 437 people
- Sponsor
- Hospital Clinic of Barcelona
Microbial Colonization
Effect of Probiotics on Infant's Fecal Microbiota Composition
Randomized clinical trial to evaluate the effect of two probiotic strains which belong to Bifidobacterium Longum and Pediococcus pentosaceus species on fecal microbiota composition in healthy infants.
- Trial name
- BABYCARE (NCT05524649)
- Testing
- Food Supplement 1, Food Supplement 2
- Where
- 2 sites in Mexico, Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Clostridium Difficile
Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection
Fecal microbiota transplantation (FMT) has been very effective for patients who suffer from mild C diff infection (CDI) which recurs but it is unclear how effective FMT alone is in treating severe and fulminant CDI.
- Trial name
- NCT03760484
- Testing
- Fidaxomicin 200 mg, fecal microbiota transplantation (FMT)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Decompensated Cirrhosis, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Decompensated Cirrhosis
Imbalance of gut bacteria is suspected to play a key role driving the progression of cirrhosis and there is hope manipulation of these bacteria may be beneficial.
- Trial name
- FMTDC (NCT03014505)
- Testing
- FMT, traditional treatments
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Elderly, Probiotics
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of Elderly
The study is randomized, double-blinded and placebo-controlled with a duration of 24 weeks. Following randomization, healthy elderly are randomized into two groups receiving probiotics or placebo.
- Conditions
- Elderly, Probiotics, Clostridium Difficile, Gut Microbiota
- Trial name
- NCT02207140
- Testing
- HOWARU Restore
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gabriella C. van Zanten
Fatigue Syndrome, Chronic, Microbial Colonization
Intestinal Microbiota and Chronic Fatigue Syndrome
Gut microbiota of 1) patients with chronic fatigue syndrome and 2) their healthy family members are analyzed. Up to 40 patients with chronic fatigue syndrome are randomized to receive either 1) a faecal transplant from a healthty…
- Trial name
- NCT04158427
- Testing
- Faecal transplantation
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Tampere University Hospital
Pitt Hopkins Syndrome
MTT for Children With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating patients with Pitt Hopkins Syndrome (PTHS) and gastrointestinal problems similar to Irritable Bowel Syndrome (IBS).
- Trial name
- NCT04132427
- Testing
- vancomycin, magnesium citrate, microbiota
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arizona State University
Inflammation
Effects of Adding Chickpeas to the American Diet (Long Term Study)
This prospective study will assess the effects of adding legumes, especially chick peas, to the diet of healthy adults on the commensal bacteria from feces of human subjects and resulting self-reported GI symptoms as well as…
- Trial name
- NCT02375373
- Testing
- Observational Chickpea Diet
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Acute Liver Failure
To Assess the Role of Fecal Microbiota Transplant in Acute Liver Failure
All patients of Acute liver failure not meeting the KCH (King's College Hospital) criteria/or meeting KCH criteria not having option of liver transplant will be recruited for the trial.
- Trial name
- NCT03363022
- Testing
- Standard Medical Treatment, Fecal Microbiota Transplant
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Biliary Atresia
Gut Microbiome in Biliary Atresia
The investigator will investigate the gut-microbiome and liver elasticity of the Biliary Atresia (BA)-patients before and after Kasai operation.
- Trial name
- NCT04260503
- Testing
- Monitoring of the gut-microbiome and ultrasound elasticity., Monitoring of the gut-microbiome, Monitoring of the gut-microbiome.
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Clostridium Difficile, Pseudomembranous Colitis
Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection
Fecal microbiota transplantation (FMT) is acknowledged as a highly effective treatment for recurrent Clostridium difficile infection (CDI). Usually single fecal infusion achieves satisfactory cure rates of recurrent CDI).
- Trial name
- NCT03427229
- Testing
- Single-infusion FMT, Vancomycin (before randomization), multiple-infusion FMT
- Volunteers
- 58 people
- Sponsor
- Catholic University of the Sacred Heart
Necrotizing Enterocolitis
Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC) - Clinical Study
The aim of the study is to assess the safety of fecal microbiota transplantation (FMT) as a preventive method for the development of Necrotizing enterocolitis (NEC) in a group of premature infants.
- Trial name
- NCT06333405
- Testing
- Fecal Microbiota Transplantation
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Fecal Microbiota Transplantation
Profiling Fecal Samples for Selection of Donors of Feces
Fecal microbiota transplantation (FMT) represents a promising therapeutic in numerous clinical situations associated with dysbiosis.
- Trial name
- PROFIT (NCT04078581)
- Testing
- Questionnaire and fecal sample collection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Complicated With Refractory Intestinal Infections
Washed Microbiota Transplantation for Patients With 2019-nCoV Infection
Gut dysbiosis co-exists in patients with coronavirus pneumonia. Some of these patients would develop secondary bacterial infections and antibiotic-associated diarrhea (AAD).
- Trial name
- NCT04251767
- Testing
- washed microbiota transplantation
- Where
- China
- Sponsor
- The Second Hospital of Nanjing Medical University
Chronic Pouchitis, Pouchitis
Fecal Microbiota Transplant for Patients With Chronic Pouchitis
The purpose of this research study is to assess the safety and efficacy of fecal microbiota transplant (FMT) in the treatment of chronic pouchitis.
- Trial name
- NCT05829109
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Maia Kayal
Advanced Gastric Cancer
Fecal Microbiota Transplantation (FMT) in Patients With Advanced Gastric Cancer
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT capsules combined with chemotherapy and anti-PD1/PDL1 therapy in the advanced gastric…
- Trial name
- NCT06346093
- Testing
- Fecal Microbiota Transplantation Capsules
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Irritable Bowel Syndrome, Diarrhea
Fecal Microbiota Transplantation for IBS
The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with…
- Trial name
- NCT05776914
- Testing
- Donor Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Madhusudan (Madhu) Grover, MBBS
Gastrointestinal Diseases, Colic
Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics
The aim of the study is to elucidate the relationship between postnatal antibiotic administration on development of gut microbiota and possible protective influence of simultaneously administration of probiotic during antibiotic…
- Trial name
- NCT02865564
- Testing
- Lactobacillus reuteri DSM 17938, ampicillin and gentamicin
- Where
- Slovenia
- Volunteers
- 98 people
- Sponsor
- University Medical Centre Ljubljana