Clinical trials: Female Contraception
Contraception
E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - United States/Canada Study
The objectives of this study are to evaluate the contraceptive efficacy, vaginal bleeding pattern (cycle control), and the general safety and acceptability of the 15 mg estetrol (E4)/3 mg drospirenone (DRSP) combination in…
- Trial name
- NCT02817841
- Testing
- 15 mg E4/3 mg DRSP
- Where
- 2 sites in United States, Canada
- Volunteers
- 2,148 people, healthy volunteers welcome
- Sponsor
- Estetra
Contraception, Drug Interactions
Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy
Data on the interaction between the etonogestrel (ENG) implant and antiepileptic drug (AED) regimen are scarce. We will evaluated the effect of 2 AED regimens (1 including carbamazepine and the other topiramate) on the…
- Trial name
- NCT03307863
- Testing
- Carbamazepine-Implant, Topiramate-Implant, Implant
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Contraception
E4/DRSP Single and Multiple Dose PK and Early QT Study
This study is conducted to evaluate the effect of single and multiple therapeutic and supratherapeutic oral doses of E4/DRSP combinations on PK parameters, safety, tolerability and on cardiac repolarization, as detected by QT…
- Trial name
- NCT02874248
- Testing
- 15 mg E4/3 mg DRSP, 30 mg E4/6 mg DRSP, 60 mg E4/12 mg DRSP
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Estetra
Contraception
Transdermal Contraceptive Patch - Endometrial Effects Study
The aim of the present study is to investigate the effects of the transdermal patch on the endometrium in healthy women who require contraception.
- Trial name
- NCT00896571
- Testing
- Ethinylestradiol/Gestogene (BAY86-5016)
- Where
- Germany
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Bayer
Pharmacokinetics, Therapeutic Equivalency
Bioequivalence Study of the Oral Contraceptive (OC) Tablet Containing Norgestimate (NGM)/Ethinyl Estradiol (EE) With or Without Folic Acid in Healthy Women.
The purpose of the study is to determine the bioequivalence of Norgestimate (NGM) and Ethinyl Estradiol (EE) in 2 formulations of 250 mcg NGM/25 mcg EE, 1 without folic acid and 1 containing 400 mcg folic acid.
- Conditions
- Pharmacokinetics, Therapeutic Equivalency, Contraceptives, Oral
- Trial name
- NCT00709644
- Testing
- Norgestimate; Ethinyl Estradiol; Folic acid.
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Contraception
Administration of Oral Contraceptives at Different Times of the Follicular Phase of the Menstrual Cycle
We hypothesize that administration of OCs at varying follicular diameters will provide an appropriate model for the study of follicular atresia in women.
- Trial name
- NCT00204438
- Testing
- 0.15mg desogestrel /0.03mg ethinyl estradiol
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Adverse Effect of Oral Contraceptives, Initial Encounter
The Effect of Hormonal Contraception on Female
The aim- To evaluate the impact of combined oral contraceptives on women's psychosexual, metabolic, blood coagulation, hormonal and genetic measures.
- Trial name
- HORMCONTRA (NCT01852786)
- Testing
- Contraceptives, Oral, Combined, Controls
- Where
- Lithuania
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Pregnancy Prevention
A Study to Evaluate the Efficacy and Safety of DR-103 for the Prevention of Pregnancy
This is an open-label, single-treatment study. All subjects will receive 12 months of oral contraceptive therapy with DR-103. Study participants will receive physical and gynecological exams, including Pap smear.
- Trial name
- NCT00996580
- Testing
- DR-103
- Where
- 94 sites in United States
- Volunteers
- 3,597 people, healthy volunteers welcome
- Sponsor
- Teva Women's Health
Contraception
Sayana Press UK Self-Injection Study
A one-year evaluation of Sayana Press self injection in women of reproductive age in the United Kingdom (UK).
- Trial name
- NCT03034057
- Testing
- Sayana Press
- Where
- 28 sites in United Kingdom
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Pfizer
Female, Premenopausal
The Influence of Plan B® on Cardiovascular Health.
The goal of this double-blind randomized controlled trial is to learn about the impacts of a single dose of Plan B® on the cardiovascular system in young, health, premenopausal females.
- Trial name
- LEVOH (NCT07759635)
- Testing
- Plan B (Levonorgestrel)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Contraception
Russia/Ukraine Suppression of Ovarian Activity Study
The purpose of this study is to look into the effectiveness of a new investigational medication applied as a transdermal patch. The patch is applied on the skin with study medication that is absorbed through the skin suppressing…
- Trial name
- NCT02550977
- Testing
- Gestodene/EE Patch (BAY86-5016)
- Where
- 8 sites in Russia, Ukraine
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Bayer
Contraception
Effects on Bone Mineral Density (BMD) of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG/EE (292005)(P05765)(COMPLETED)
The primary purpose of this study is to evaluate the effects of the NOMAC-E2 combined oral contraceptive (COC) on bone mineral density (BMD).
- Trial name
- NCT00511342
- Testing
- NOMAC-E2, LNG-EE
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Contraception
Comparative Efficacy of Lidocaine Spray Versus Vaginal Misoprostol in IUD Insertion
the aim of the present study is to compare the safety and efficacy of lidocaine spray versus misoprostol in reducing pain during IUD insertion in adolescents and nulliparous women
- Trial name
- NCT04339049
- Testing
- lidocaine spray, vaginal misoprostol
- Where
- Egypt
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neural Tube Defects, Contraception
Efficacy and Safety Study for an Oral Contraceptive Containing Folate
The purpose of this study is to determine whether the study drug is safe and effective
- Conditions
- Neural Tube Defects, Contraception, Oral Contraceptives (OC)
- Trial name
- NCT00468481
- Testing
- Drospirenone/Ethinylestradiol/Methyltetrahydrofolate, Drospirenone/Ethinylestradiol (Yaz)
- Where
- 9 sites in United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Bayer
Contraception
Sayana® Press Self-injection Study in Malawi
The feasibility of Sayana Press self-injection and the potential for this practice to increase contraceptive continuation has never been assessed in family planning programs in low-resource settings.
- Trial name
- NCT02293694
- Testing
- Sayana Press
- Where
- Malawi
- Volunteers
- 735 people, healthy volunteers welcome
- Sponsor
- FHI 360
Contraception
Trial Evaluating Folic Acid Supplementation by Concomitant Administration of Ethinyl Estradiol + Levonorgestrel
This trial evaluated folic acid supplementation after oral administration of the ethinyl estradiol + levonorgestrel + folic acid (0.02 mg + 0.10 mg + 0.4 mg) coated tablet (Level-Fol® Biolab Sanus Farmacêutica, São Paulo, Brazil)…
- Trial name
- NCT03359057
- Testing
- ethinyl estradiol + levonorgestrel + folic acid, Folic Acid
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Contraception, Bleeding Pattern
Assessment of a Vaginal Ring With Meloxicam on Ovarian Cycle in Fertile Women
In this study, the investigators propose to assess if a non-hormonal agent is absorbed by a local route (vaginal) and to observe the effect on follicular development.
- Trial name
- NCT01839643
- Testing
- Meloxicam 2.4 g, Meloxicam 3.0 g
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Laboratorios Andromaco S.A.
Contraception
A Study to Evaluate Inhibition of Ovulation of Two Oral Estrogen/Progestogen Regimens in Healthy, Young Females Over a Period of 3 Treatment Cycles
Investigation of a new pill containing an estrogen and a progestin in order to monitor the inhibition of the ovulation in young healthy females over 3 treatment cycles
- Trial name
- NCT00631124
- Testing
- BAY86-4891 (Estradiol / Drospirenone)
- Where
- 2 sites in Germany
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Bayer
Alcohol Exposed Pregnancy, Unplanned Pregnancy
Optimizing a Digital AEP Risk Intervention With Native Women and Communities
The purpose of Aim 1 of the study is to gather quantitative and qualitative information to inform the development of a digital app tailored for Native American women to help them avoid a pregnancy affected by alcohol.
- Conditions
- Alcohol Exposed Pregnancy, Unplanned Pregnancy, Alcohol Use, Unspecified, Contraception Use
- Trial name
- CARRIINative (NCT06324929)
- Testing
- CARRII Native Rapid Pilot Testing
- Where
- United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Contraception
Effect of Food on the Bioavailability of 15 mg Estetrol/3 mg Drospirenone Tablets in Healthy Female Volunteers
This single-center, open-label, randomized, balanced, single-dose, two-treatment, two-period, two-sequence crossover study was conducted under medical supervision in 28 healthy female volunteers.
- Trial name
- NCT02852681
- Testing
- 15 mg E4/3 mg DRSP
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Estetra